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A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.

artículo científico publicado en 2008

APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis

scientific article published on 01 September 2003

Abstract 4683: Smoking is associated with mosaic loss of chromosome Y

Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease

artículo científico publicado en 2014

Age-related somatic structural changes in the nuclear genome of human blood cells

artículo científico publicado en 2012

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

artículo científico publicado en 2016

Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

artículo científico publicado en 2016

Alpha-synuclein and chaperones in dementia with Lewy bodies.

artículo científico publicado en 2005

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

artículo científico publicado en 2017

Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

artículo científico publicado en 2020

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.

artículo científico publicado en 2018

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

artículo científico publicado en 2016

Antibodies against alpha-synuclein reduce oligomerization in living cells

artículo científico publicado en 2011

Association study of cholesterol-related genes in Alzheimer's disease.

artículo científico publicado en 2007

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

scientific article published on 01 May 2019

Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models

artículo científico publicado en 2014

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

artículo científico publicado en 2009

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

artículo científico publicado en 2018

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

artículo científico publicado en 2016

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

artículo científico publicado en 2016

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

artículo científico publicado en 2014

Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

artículo científico publicado en 2008

Conformationally altered proteins cause neurodegenerative diseases

artículo científico publicado en 2005

Consensus guidelines for lumbar puncture in patients with neurological diseases

artículo científico publicado en 2017

Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels

artículo científico publicado en 2006

Corrigendum to "Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways" [Free Rad. Biol. Med. (2017) 421-431].

artículo científico publicado en 2018

Cystatin C Levels are Positively Correlated with both Aβ42 and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

scholarly article by Johan Sundelöf et al published 11 August 2010 in Journal of Alzheimer's Disease

Decreased HHV-6 IgG in Alzheimer's Disease

scientific article published on 20 February 2017

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

artículo científico publicado en 2007

Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.

artículo científico publicado en 2005

Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease

artículo científico publicado en 2013

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models

artículo científico publicado en 2016

Disordered proteins in dementia

artículo científico publicado en 2002

Dual-Task Tests Predict Conversion to Dementia-A Prospective Memory-Clinic-Based Cohort Study

artículo científico publicado en 2020

Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study

scientific article published on 29 July 2020

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

artículo científico publicado en 2018

Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein

artículo científico publicado en 2010

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

artículo científico publicado en 2007

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

artículo científico publicado en 2017

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

artículo científico publicado en 2012

Family-based association between Alzheimer's disease and variants in UBQLN1

artículo científico publicado en 2005

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

artículo científico publicado en 2018

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

artículo científico publicado en 2008

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro

artículo científico publicado en 2011

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

artículo científico publicado en 2014

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

artículo científico publicado en 2019

Genetic predisposition to mosaic Y chromosome loss in blood

scientific article published on 20 November 2019

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

Genotyping of apolipoprotein E: comparative evaluation of different protocols

scientific article published on 01 November 2003

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

artículo científico publicado en 2008

High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease

artículo científico publicado en 2016

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

scholarly article by Johan Sundelöf et al published 7 January 2011 in Journal of Alzheimer's Disease

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

artículo científico publicado en 2017

Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells

artículo científico publicado en 2016

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

artículo científico publicado en 2010

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

artículo científico publicado en 2014

Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

artículo científico

Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers

In Situ Proximity Ligation Assay Reveals Co-Localization of Alpha-Synuclein and SNARE Proteins in Murine Primary Neurons.

artículo científico publicado en 2018

In vivo multiphoton microscopy of deep tissue with gradient index lenses

Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains

artículo científico publicado en 2007

Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain

artículo científico publicado en 2016

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures

artículo científico

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease

artículo científico publicado en 2014

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

artículo científico publicado en 2010

Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

artículo científico publicado en 2017

Interference from heterophilic antibodies in amyloid-β oligomer ELISAs

artículo científico publicado en 2010

Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease

artículo científico publicado en 2004

Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation

artículo científico publicado en 2012

Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways

artículo científico publicado en 2017

Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

artículo científico publicado en 2007

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

artículo científico publicado en 2016

Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome.

artículo científico publicado en 2014

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

artículo científico publicado en 2013

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

artículo científico publicado en 2016

Mosaic loss of chromosome Y in leukocytes matters

artículo científico publicado en 2019

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

artículo científico publicado en 2018

Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.

artículo científico publicado en 2014

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

artículo científico publicado en 2013

Neurofilament ELISA validation.

artículo científico publicado en 2009

No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain

artículo científico publicado en 2006

No association between CALHM1 and Alzheimer's disease risk

artículo científico publicado en 2008

No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

scientific article published on 23 November 2009

Novel progranulin mutation detected in 2 patients with FTLD.

artículo científico publicado en 2011

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.

artículo científico publicado en 2013

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

artículo científico publicado en 2010

Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

artículo científico publicado en 2015

Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study

artículo científico publicado en 2008

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

artículo científico publicado en 2009

Quantification of the brain proteome in Alzheimer's disease using multiplexed mass spectrometry

artículo científico publicado en 2014

Quantitative interaction proteomics of neurodegenerative disease proteins.

artículo científico publicado en 2015

Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

artículo científico publicado en 2017

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

artículo científico publicado en 2009

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

artículo científico publicado en 2017

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis

artículo científico publicado en 2013

Reduced plasma desmosterol-to-cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease

artículo científico publicado en 2015

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

artículo científico publicado en 2018

Risk factors for subarachnoid haemorrhage: a nationwide cohort of 950 000 adults

artículo científico publicado en 2019

Self-reported difficulty initiating sleep and early morning awakenings are associated with nocturnal diastolic non-dipping in older white Swedish men

scientific article published on 07 August 2020

Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

artículo científico publicado en 2014

Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis

artículo científico publicado en 2010

Single molecule profiling of tau gene expression in Alzheimer's disease.

artículo científico publicado en 2007

Stability of Proteins in Dried Blood Spot Biobanks

artículo científico publicado en 2017

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease

artículo científico publicado en 2018

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

artículo científico publicado en 2010

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

artículo científico publicado en 2013

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.

artículo científico publicado en 2011

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

artículo científico publicado en 2010

The amyloid-β degradation pattern in plasma--a possible tool for clinical trials in Alzheimer's disease

artículo científico publicado en 2014

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease

artículo científico publicado en 2020

The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

artículo científico publicado en 2008

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties ⬇️

artículo científico publicado el 1 de febrero de 2011

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease.

artículo científico publicado en 2007

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

artículo científico publicado en 2005

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease

artículo científico publicado en 2019

Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy

artículo científico publicado en 2003

[Alzheimer's disease - the most common cause of dementia]

scientific article published on 09 March 2020

[Rare mutations aim toward future treatment].

artículo científico publicado en 2009

α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities

artículo científico publicado en 2016

α-Synuclein strains target distinct brain regions and cell types

scientific article published on 02 December 2019

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