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Lista de obras de Federico Innocenti

"Irinogenetics" and UGT1A: from genotypes to haplotypes

artículo científico publicado en 2004

25-Hydroxyvitamin D levels and survival in advanced pancreatic cancer: findings from CALGB 80303 (Alliance).

artículo científico publicado en 2014

5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice.

artículo científico publicado en 2005

8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016

article

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.

artículo científico publicado en 2018

A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study

artículo científico publicado en 2018

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes

artículo científico publicado en 2019

A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.

artículo científico publicado en 2005

A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303

scientific journal article

A genome-wide integrative study of microRNAs in human liver

artículo científico publicado en 2013

A guide to the current Web-based resources in pharmacogenomics.

scientific article published on January 2013

A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.

artículo científico publicado en 2014

A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

artículo científico publicado en 2003

A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours

artículo científico publicado en 2008

A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer

artículo científico publicado en 2004

A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital

artículo científico publicado en 2004

A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium

artículo científico publicado en 2018

ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

artículo científico publicado en 2015

All You Need to Know About DPYD Genetic Testing for Patients Treated With Fluorouracil and Capecitabine: A Practitioner-Friendly Guide

scientific article published on 16 November 2020

An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance)

scientific article published on 01 August 2019

Architecture of pharmacogenomic associations: structures with functional foundations or castles made of sand?

artículo científico publicado en 2013

Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).

artículo científico publicado en 2016

Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma

artículo científico publicado en 2016

Association of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer

scientific article published on 17 September 2020

Association of Diet Quality With Survival Among People With Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial

artículo científico publicado en 2020

Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405

scientific article published on 13 August 2019

Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)

artículo científico publicado en 2016

Body Mass Index and Weight Loss in Metastatic Colorectal Cancer in CALGB (Alliance)/SWOG 80405

artículo científico publicado en 2020

Bridging genomics research between developed and developing countries: the Genomic Medicine Alliance

Bringing a genomic perspective to the safety of drug treatment in oncology.

artículo científico publicado en 2017

Can knowledge of germline markers of toxicity optimize dosing and efficacy of cancer therapy?

artículo científico publicado en 2012

Challenges in the development and use of pharmacogenomic markers in oncology

artículo científico publicado en 2007

Clinical pharmacology and pharmacogenetics of gemcitabine

artículo científico publicado en 2009

Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics

artículo científico publicado en 2009

DPYD variants to predict 5-FU toxicity: the ultimate proof

artículo científico publicado en 2014

Diabetes and Clinical Outcome in Patients With Metastatic Colorectal Cancer: CALGB 80405 (Alliance)

artículo científico publicado en 2019

Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway

artículo científico publicado en 2013

Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer

artículo científico publicado en 2014

Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial.

artículo científico publicado en 2017

Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

artículo científico publicado en 2003

Effects of green tea compounds on irinotecan metabolism

artículo científico publicado en 2006

Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes

artículo científico publicado en 2005

Estimating the Effectiveness of DPYD Genotyping in Italian Individuals Suffering from Cancer Based on the Cost of Chemotherapy-Induced Toxicity

scientific article published on 30 May 2019

Ethnic differences and functional analysis of MET mutations in lung cancer

artículo científico publicado en 2009

Exceptional Chemotherapy Response in Metastatic Colorectal Cancer Associated With Hyper-Indel-Hypermutated Cancer Genome and Comutation of POLD1 and MLH1

scientific article published on 27 April 2017

Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer

artículo científico publicado en 2015

Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303).

artículo científico publicado en 2010

Genetic Analysis in Translational Medicine: The 2010 GOLDEN HELIX Symposium

artículo científico publicado en 2011

Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy.

artículo científico publicado en 2014

Genetic effects on liver chromatin accessibility identify disease regulatory variants

artículo científico publicado en 2021

Genetic variants of VEGFA and FLT4 are determinants of survival in renal cell carcinoma patients treated with sorafenib

artículo científico publicado en 2018

Genetic variation determines VEGF-A plasma levels in cancer patients

artículo científico publicado en 2018

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

artículo científico publicado en 2014

Genomic Characterization of Metformin Hepatic Response

artículo científico publicado en 2016

Genomic analysis of germline variation associated with survival of colorectal cancer patients treated with chemotherapy plus biologics in CALGB/SWOG 80405 (Alliance)

scientific article published on 21 September 2020

Genomics into Healthcare: the 5th Pan Arab Human Genetics Conference and 2013 Golden Helix Symposium

artículo científico publicado en 2014

Genotype-Guided Dosing Study of FOLFIRI plus Bevacizumab in Patients with Metastatic Colorectal Cancer.

artículo científico publicado en 2016

Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer

artículo científico publicado en 2009

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups

artículo científico publicado en 2002

Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.

artículo científico publicado en 2005

Hidden Markov Model-Based CNV Detection Algorithms for Illumina Genotyping Microarrays

artículo científico publicado en 2014

Identification of a Genomic Region between and Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)

artículo científico publicado en 2018

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

artículo científico publicado en 2011

Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance)

artículo científico publicado en 2019

Implications of genome-wide association studies in cancer therapeutics

artículo científico publicado en 2013

In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes

artículo científico publicado en 2002

Individualizing dosing of irinotecan

artículo científico publicado en 2010

Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D levels and survival among patients with metastatic colorectal cancer

scientific article published on 18 May 2019

Insights, challenges, and future directions in irinogenetics

artículo científico publicado en 2007

Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine

artículo científico publicado en 2012

Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism.

artículo científico publicado en 2003

Irinogenetics: what is the right star?

artículo científico publicado en 2006

Lack of association between common polymorphisms in UGT1A9 and gene expression and activity

artículo científico publicado en 2007

Linkage disequilibrium across the UGT1A locus should not be ignored in association studies of cancer susceptibility

artículo científico publicado en 2005

Liver expression quantitative trait loci: a foundation for pharmacogenomic research.

artículo científico publicado en 2012

MTHFR and ALL risk: a challenge

artículo científico publicado en 2006

Mechanisms of genetic regulation in gene expression: examples from drug metabolizing enzymes and transporters

artículo científico publicado en 2010

Moving away from candidate genes: a 'genome-wise' discovery of gemcitabine myelotoxicity

artículo científico publicado en 2012

Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome

scientific article published on 13 March 2019

Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer

artículo científico publicado en 2011

Nutrigenetics and nutrigenomics: ready for clinical use or still a way to go?

artículo científico publicado en 2020

One SNP for both cancer risk and survival in colorectal cancer: two for the price of one?

artículo científico publicado en 2012

Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients

scientific article published on 17 March 2020

Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan

artículo científico publicado en 2009

Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?

artículo científico publicado en 2008

Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping

artículo científico publicado en 2006

Pharmacogenomics: paving the path to personalized medicine

artículo científico publicado en 2010

Pharmacogenomics: road to anticancer therapeutics nirvana? ⬇️

artículo científico publicado el 29 de septiembre de 2003

Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer

scientific article published on 17 February 2007

Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive diseas

artículo científico publicado en 2010

Phase III Trial Evaluating Letrozole As First-Line Endocrine Therapy With or Without Bevacizumab for the Treatment of Postmenopausal Women With Hormone Receptor-Positive Advanced-Stage Breast Cancer: CALGB 40503 (Alliance)

artículo científico publicado en 2016

Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)

scientific article published on 23 September 2019

Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.

artículo científico publicado en 2013

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

artículo científico publicado en 2009

Prognostic and Predictive Biomarkers in Metastatic Colorectal Cancer Patients Receiving Regorafenib

artículo científico publicado en 2020

R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.

scientific article published on 21 May 2009

Recent progress and clinical importance on pharmacogenetics in cancer therapy.

artículo científico publicado en 2011

Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.

scientific article published on 05 February 2013

Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines

artículo científico publicado en 2007

Reply to L. Casadaban et al.

artículo científico publicado en 2017

Reply to S. Sorscher

scientific article published on 03 July 2019

Role of UGT1A1*6 in irinogenetics in Asians

scientific article published on 01 November 2007

Searching for tissue-specific expression pattern-linked nucleotides of UGT1A isoforms

artículo científico publicado en 2007

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

artículo científico publicado en 2008

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes

artículo científico publicado en 2006

Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy

artículo científico publicado en 2016

The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy. "The Odyssey from Hope to Practice", Santorini, Greece, 30 September⁻3 October 2018

article

The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds

artículo científico publicado en 2008

The association between adverse events and outcome under checkpoint inhibitors: Where is the deal?

artículo científico publicado en 2020

The effect of thalidomide on the pharmacokinetics of irinotecan and metabolites in advanced solid tumor patients

artículo científico publicado en 2011

The genotype for DPYD risk variants in colorectal cancer patients and the related toxicity management costs in clinical practice

article

The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity

scientific article published on 01 January 2007

The role of pharmacogenetics in cancer therapeutics

artículo científico publicado en 2006

The use of genomic information to optimize cancer chemotherapy

artículo científico publicado en 2011

The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation

artículo científico publicado en 2018

Translating the cancer genome into clinically useful tools and strategies

artículo científico publicado en 2009

Translation of pharmacogenetic knowledge into cancer therapeutics.

artículo científico publicado en 2007

UGT pharmacogenomics: implications for cancer risk and cancer therapeutics

scientific article published on 01 August 2003

UGT1A1 genotyping in patients undergoing treatment with irinotecan.

artículo científico publicado en 2005

UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers

scientific article published on 01 August 2007

Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy

artículo científico publicado en 2010

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

artículo científico publicado en 2016

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper

artículo científico publicado en 2020

fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies.

artículo científico publicado en 2019

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