Lista de obras -

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

artículo científico publicado en 2011

Acute compressive stress activates RHO/ROCK-mediated cellular processes.

artículo científico publicado en 2018

Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells

artículo científico publicado en 2019

Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP

artículo científico publicado en 2021

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity ⬇️

artículo científico publicado el 27 de noviembre de 2001

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

artículo científico publicado en 2010

Ex vivo culture of intact human patient derived pancreatic tumour tissue

artículo científico publicado en 2021

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

artículo científico publicado en 2011

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

artículo científico publicado en 2013

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

artículo científico publicado en 2015

Live cell in vitro and in vivo imaging applications: accelerating drug discovery

artículo científico publicado en 2011

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

scientific article published on 18 November 2019

Molecular mobility and activity in an intravital imaging setting - implications for cancer progression and targeting

artículo científico publicado en 2018

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

scientific article published on 07 August 2019

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells ⬇️

artículo científico publicado el 19 de septiembre de 2011

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

artículo científico publicado en 2009

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

artículo científico publicado en 2017

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

artículo científico publicado en 2012

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

artículo científico publicado en 2021

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

artículo científico publicado en 2021

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

artículo científico publicado en 2011

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

artículo científico publicado en 2021

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

artículo científico publicado en 2010

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

artículo científico publicado en 2009

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

artículo científico publicado en 2011

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

artículo científico publicado en 2009

Recent advances in understanding the complexities of metastasis

artículo científico publicado en 2018

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

artículo científico publicado en 2015

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.

artículo científico publicado en 2018

Single cell transcriptome atlas of mouse mammary epithelial cells across development

artículo científico publicado en 2021

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

artículo científico publicado en 2011

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

artículo científico publicado en 2017

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

artículo científico publicado en 2017

Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation

artículo científico publicado en 2020

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

artículo científico publicado en 2015

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

article published in 2018

The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

scientific article published on 01 August 2019

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

artículo científico publicado en 2014

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

artículo científico publicado en 2016

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

artículo científico publicado en 2017

Lista de obras de

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

Acute compressive stress activates RHO/ROCK-mediated cellular processes.

Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells

Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity ⬇️

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

Ex vivo culture of intact human patient derived pancreatic tumour tissue

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Live cell in vitro and in vivo imaging applications: accelerating drug discovery

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Molecular mobility and activity in an intravital imaging setting - implications for cancer progression and targeting

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells ⬇️

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

Recent advances in understanding the complexities of metastasis

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.

Single cell transcriptome atlas of mouse mammary epithelial cells across development

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.