Lista de obras -

A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.

artículo científico publicado en 2018

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis

artículo científico publicado en 2017

A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening ⬇️

artículo científico publicado el 1 de enero de 2009

A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine

artículo científico publicado en 2016

A dive into membrane dynamics with sponge peptides

scientific article published on 01 May 2015

A functional genomics approach to the mode of action of apratoxin A.

artículo científico publicado en 2006

A genome-wide overexpression screen in yeast for small-molecule target identification

artículo científico publicado en 2005

A genomic screen for activators of the antioxidant response element

artículo científico publicado en 2007

A small-molecule inducer of the antioxidant response element

artículo científico publicado en 2010

Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid

artículo científico publicado en 2009

Advances in exploring the therapeutic potential of marine natural products

artículo científico publicado en 2019

Ahp-Cyclodepsipeptide Inhibitors of Elastase: Lyngbyastatin 7 Stability, Scalable Synthesis, and Focused Library Analysis

scientific article published on 04 March 2020

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7

scientific article published on 09 September 2020

Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. ⬇️

artículo científico publicado en 2015

An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.

artículo científico publicado en 2018

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

artículo científico publicado en 2010

Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.

artículo científico publicado en 2008

Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors

artículo científico publicado en 2017

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

scientific article published on 01 July 2019

Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation

artículo científico publicado en 2009

Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing ⬇️

artículo científico publicado en 2017

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells

artículo científico publicado en 2021

Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa ⬇️

artículo científico publicado en 2009

Biological effects of Byrsocarpus coccineus in vitro

artículo científico publicado en 2010

Biological targets and mechanisms of action of natural products from marine cyanobacteria

artículo científico publicado en 2015

Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities

artículo científico publicado en 2003

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.

artículo científico publicado en 2016

Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance

artículo científico publicado en 2015

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata ⬇️

scientific article published on 05 July 2016

Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma?

artículo científico publicado en 2011

Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida ⬇️

artículo científico publicado el 24 de septiembre de 2010

ChemInform Abstract: New Apratoxins of Marine Cyanobacterial Origin from Guam and Palau

artículo científico

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles ⬇️

artículo científico publicado en 2019

Combination Therapy for Renal Cell Cancer: What Are Possible Options? ⬇️

artículo científico publicado el 12 de noviembre de 2011

Combination therapy targeting cancer metabolism ⬇️

artículo científico publicado el 13 de octubre de 2010

Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole

artículo científico publicado en 2009

Construction and characterization of melanocortin-2 and -4 receptor chimeras

artículo científico publicado en 2009

Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D.

artículo científico publicado en 2003

Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors".

artículo científico publicado en 2017

Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii.

artículo científico publicado en 2017

Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida

artículo científico publicado en 2016

Cover Feature: Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer (ChemBioChem 8/2018)

scientific article published in 2018

Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system

artículo científico publicado en 2013

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases ⬇️

artículo científico publicado el 26 de noviembre de 2012

Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways.

artículo científico publicado en 2017

Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam ⬇️

artículo científico publicado en 2010

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

artículo científico publicado en 2018

Discovery and Mechanism of Natural Products as Modulators of Histone Acetylation ⬇️

artículo científico publicado el 1 de julio de 2012

Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium

artículo científico publicado en 2019

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria ⬇️

scientific article published on 19 February 2019

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

artículo científico publicado en 2015

Discovery of new A- and B-type laxaphycins with synergistic anticancer activity ⬇️

artículo científico publicado en 2018

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M

artículo científico publicado en 2020

Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium

scientific article published on 17 July 2018

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria ⬇️

artículo científico publicado en 2016

Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

scientific article published on 16 May 2020

Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization

scientific article published on 01 April 2020

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa

artículo científico publicado en 2008

Evaluation of class I HDAC isoform selectivity of largazole analogues

artículo científico publicado en 2014

Fungal epithiodiketopiperazines carrying α,β-polysulfide bridges from Penecillium steckii YE, and their chemical interconversion

scientific article published on 20 August 2020

Genome-wide overexpression screen for activators of antioxidant gene transcription

artículo científico publicado en 2008

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides ⬇️

artículo científico publicado el 4 de noviembre de 2010

Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation

artículo científico publicado en 2014

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation ⬇️

artículo científico publicado en 2009

Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. ⬇️

artículo científico publicado en 2017

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis

artículo científico publicado en 2015

Heterologous production of cyanobacterial compounds

artículo científico publicado en 2021

High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain ⬇️

artículo científico publicado en 2018

High-throughput gene screen reveals modulators of nuclear shape

scientific article published on 22 April 2020

Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity

artículo científico publicado en 2014

In Vitro and In Vivo Osteogenic Activity of Largazole.

artículo científico publicado en 2011

In Vitro and in Vivo Characterization of a Tunable Dual-Reactivity Probe of the Nrf2-ARE Pathway ⬇️

artículo científico publicado el 17 de junio de 2013

Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. ⬇️

artículo científico publicado en 2010

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales) ⬇️

artículo científico publicado en 2018

Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 Pathway

artículo científico publicado en 2024

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. ⬇️

artículo científico publicado en 2010

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria ⬇️

artículo científico publicado en 2019

Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer ⬇️

artículo científico publicado en 2017

Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp.

artículo científico publicado en 2008

Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides

artículo científico publicado en 2009

Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases

scientific article published on 19 June 2020

Largazole pharmacokinetics in rats by LC-MS/MS.

artículo científico publicado en 2014

Largazole: From discovery to broad-spectrum therapy ⬇️

artículo científico publicado el 14 de febrero de 2012

Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp

artículo científico publicado en 2002

Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides

artículo científico publicado en 2007

Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp.

artículo científico publicado en 2007

Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena ⬇️

artículo científico publicado en 2009

Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa ⬇️

scientific article published on 24 January 2011

Malyngamide 3 and Cocosamides A and B from the Marine Cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam ⬇️

artículo científico publicado el 22 de febrero de 2011

Marine Natural Products: A New Wave of Drugs? ⬇️

artículo científico publicado el 1 de septiembre de 2011

Marine cyanobacterial fatty acid amides acting on cannabinoid receptors.

artículo científico publicado en 2012

Modular Strategies for Structure and Function Employed by Marine Cyanobacteria: Characterization and Synthesis of Pitinoic Acids ⬇️

artículo científico publicado el 5 de agosto de 2013

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

artículo científico publicado en 2014

Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis

artículo científico publicado en 2010

Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer

artículo científico publicado en 2016

Natural products as modulators of eukaryotic protein secretion

artículo científico publicado en 2020

New apratoxins of marine cyanobacterial origin from Guam and Palau

artículo científico publicado en 2002

New methods for isolation and structure determination of natural products

scientific article published on 28 June 2019

Photosynthetic Production of Sunscreen Shinorine Using an Engineered Cyanobacterium

artículo científico publicado en 2018

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida

artículo científico publicado en 2009

Pitiamides A and B, Multifunctional Fatty Acid Amides from Marine Cyanobacteria ⬇️

artículo científico publicado en 2016

Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. ⬇️

artículo científico publicado en 2011

Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam ⬇️

artículo científico publicado en 2010

Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers

artículo científico publicado en 2017

Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides

scientific article published on 19 February 2008

Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp ⬇️

artículo científico publicado en 2011

Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-Inflammatory Effects in Bronchial Epithelial Cells ⬇️

artículo científico publicado el 28 de enero de 2013

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity

scientific article published on 23 March 2020

Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses.

artículo científico publicado en 2009

Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters. ⬇️

artículo científico publicado en 2018

Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway ⬇️

artículo científico publicado el 4 de enero de 2013

Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression

scientific article published on 16 September 2019

Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer. ⬇️

artículo científico publicado en 2018

Structurally diverse new alkaloids from Palauan collections of the apratoxin-producing marine cyanobacterium Lyngbya sp.

artículo científico publicado en 2003

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

artículo científico publicado en 2008

Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis

artículo científico publicado en 2016

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

artículo científico publicado en 2002

Synthesis and activity of largazole analogues with linker and macrocycle modification

artículo científico publicado en 2008

Synthesis and biological evaluation of largazole zinc-binding group analogs

artículo científico publicado en 2017

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

artículo científico publicado en 2011

Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation

artículo científico publicado en 2015

Targeting and extending the eukaryotic druggable genome with natural products

artículo científico publicado en 2020

Targeting eukaryotic proteases for natural products-based drug development

artículo científico publicado en 2020

Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium ⬇️

artículo científico publicado en 2016

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

scientific journal article

The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions

The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog

artículo científico publicado en 2003

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

artículo científico publicado en 2017

Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides ⬇️

artículo científico publicado en 2009

Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product.

artículo científico publicado en 2016

Total Synthesis of Asperphenins A and B

artículo científico publicado en 2018

Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases ⬇️

artículo científico publicado en 2015

Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin

artículo científico publicado en 2008

Total synthesis and biological evaluation of grassypeptolide A.

artículo científico publicado en 2013

Total synthesis and molecular target of largazole, a histone deacetylase inhibitor

artículo científico publicado en 2008

Total synthesis of grassystatin A, a probe for cathepsin E function ⬇️

artículo científico publicado el 7 de junio de 2012

Towards high-throughput characterization of small molecule mechanisms of action

artículo científico publicado en 2006

Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties ⬇️

scientific article published on 28 January 2020

Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp.

artículo científico publicado en 2002

Veraguamides A−G, Cyclic Hexadepsipeptides from a Dolastatin 16-Producing Cyanobacterium Symploca cf. hydnoides from Guam ⬇️

artículo científico publicado el 29 de marzo de 2011

Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

scientific article published on 28 October 2020

Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

artículo científico publicado en 2010

Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets

artículo científico publicado en 2020

Lista de obras de

A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis

A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening ⬇️

A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine

A dive into membrane dynamics with sponge peptides

A functional genomics approach to the mode of action of apratoxin A.

A genome-wide overexpression screen in yeast for small-molecule target identification

A genomic screen for activators of the antioxidant response element

A small-molecule inducer of the antioxidant response element

Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid

Advances in exploring the therapeutic potential of marine natural products

Ahp-Cyclodepsipeptide Inhibitors of Elastase: Lyngbyastatin 7 Stability, Scalable Synthesis, and Focused Library Analysis

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7

Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. ⬇️

An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.

Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation

Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing ⬇️

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells

Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa ⬇️

Biological effects of Byrsocarpus coccineus in vitro

Biological targets and mechanisms of action of natural products from marine cyanobacteria

Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.

Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata ⬇️

Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma?

Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida ⬇️

ChemInform Abstract: New Apratoxins of Marine Cyanobacterial Origin from Guam and Palau

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles ⬇️

Combination Therapy for Renal Cell Cancer: What Are Possible Options? ⬇️

Combination therapy targeting cancer metabolism ⬇️

Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole

Construction and characterization of melanocortin-2 and -4 receptor chimeras

Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D.

Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors".

Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii.

Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida

Cover Feature: Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer (ChemBioChem 8/2018)

Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases ⬇️

Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways.

Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam ⬇️

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

Discovery and Mechanism of Natural Products as Modulators of Histone Acetylation ⬇️

Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria ⬇️

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

Discovery of new A- and B-type laxaphycins with synergistic anticancer activity ⬇️

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M

Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria ⬇️

Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa

Evaluation of class I HDAC isoform selectivity of largazole analogues

Fungal epithiodiketopiperazines carrying α,β-polysulfide bridges from Penecillium steckii YE, and their chemical interconversion

Genome-wide overexpression screen for activators of antioxidant gene transcription

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides ⬇️

Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation ⬇️

Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. ⬇️

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis

Heterologous production of cyanobacterial compounds

High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain ⬇️

High-throughput gene screen reveals modulators of nuclear shape

Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity

In Vitro and In Vivo Osteogenic Activity of Largazole.

In Vitro and in Vivo Characterization of a Tunable Dual-Reactivity Probe of the Nrf2-ARE Pathway ⬇️

Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. ⬇️

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales) ⬇️

Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 Pathway

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. ⬇️

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria ⬇️

Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer ⬇️

Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp.