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2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection

artículo científico publicado en 2018

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

artículo científico publicado en 2012

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

artículo científico publicado en 2005

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

scientific article published on 19 June 2019

Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30

artículo científico publicado en 2009

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

artículo científico publicado en 2015

Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

artículo científico publicado en 2006

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)

artículo científico publicado en 2005

Analysis ofKIR3DP1Polymorphism Provides Relevant Information on CentromericKIRGene Content

artículo científico publicado en 2018

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

artículo científico publicado en 2008

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

scientific article published on 22 July 2019

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

scientific article published on 09 August 2019

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells

artículo científico publicado en 2013

Cellular and molecular basis of natural killer and natural killer-like activity.

artículo científico publicado en 2003

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

artículo científico publicado en 2011

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

artículo científico publicado en 2006

Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.

artículo científico publicado en 2010

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia

artículo científico publicado en 2002

Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation

scientific article published on 24 June 2019

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

artículo científico publicado en 2014

Different checkpoints in human NK-cell activation

artículo científico publicado en 2004

Direct involvement of CD56 in cytokine-induced killer-mediated lysis of CD56+ hematopoietic target cells.

artículo científico publicado en 2014

Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value.

artículo científico publicado en 2007

Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma

artículo científico publicado en 2004

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

artículo científico publicado en 2011

ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors

artículo científico publicado en 2015

Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice

artículo científico publicado en 2004

Effector and regulatory events during natural killer-dendritic cell interactions

artículo científico publicado en 2006

Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus.

artículo científico publicado en 2006

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

artículo científico publicado en 2006

Familial hemophagocytic lymphohistiocytosis may present during adulthood: clinical and genetic features of a small series.

artículo científico publicado en 2012

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

artículo científico

Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning

artículo científico publicado en 2014

Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients

artículo científico publicado en 2017

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

artículo científico publicado en 2015

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

artículo científico publicado en 2011

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

artículo científico publicado en 2005

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

artículo científico publicado en 2014

Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression

artículo científico publicado en 2002

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference

artículo científico publicado en 2009

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

artículo científico publicado en 2016

Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells

artículo científico publicado en 2008

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1

scientific article published on 17 August 2018

Human NK cells and their receptors.

artículo científico publicado en 2002

Human NK cells: From surface receptors to clinical applications

artículo científico publicado en 2016

Human NK cells: from surface receptors to the therapy of leukemias and solid tumors

artículo científico

Human NK receptors: from the molecules to the therapy of high risk leukemias.

artículo científico publicado en 2011

Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis

artículo científico publicado en 2005

Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias.

artículo científico

Human natural killer cells: their origin, receptors and function

artículo científico publicado en 2002

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

artículo científico publicado en 2003

Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection

article

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

artículo científico publicado en 2017

Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse

artículo científico publicado en 2007

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

scientific article published on 03 September 2020

Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.

artículo científico publicado en 2004

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation.

artículo científico publicado en 2019

Killer Ig–like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation

artículo científico publicado el 20 de enero de 2011

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

artículo científico publicado en 2004

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

artículo científico publicado en 2008

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity

artículo científico publicado en 2002

Markers and function of human NK cells in normal and pathological conditions

artículo científico publicado en 2017

Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells

artículo científico publicado en 2014

Molecular basis of familial hemophagocytic lymphohistiocytosis

artículo científico publicado en 2010

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

artículo científico publicado en 2008

Myeloma cells induce the accumulation of activated CD94low NK cells by cell-to-cell contacts involving CD56 molecules

scientific article published on 01 May 2020

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

artículo científico publicado en 2009

NK Cell-Based Immunotherapy for Hematological Malignancies

scientific article published on 16 October 2019

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia

artículo científico publicado en 2018

NK cells and ILCs in tumor immunotherapy

scientific article published on 13 August 2020

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

artículo científico publicado en 2005

NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity

artículo científico publicado en 2003

NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients

artículo científico publicado en 2007

NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

article

NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells

artículo científico publicado en 1999

Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment.

artículo científico publicado en 2015

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

artículo científico publicado en 2011

Natural Killer andNK-LikeT-Cell Activation in Colorectal Carcinoma Patients Treated with Autologous Tumor-Derived Heat Shock Protein 96

artículo científico publicado en 2005

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.

artículo científico publicado en 2004

Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties

artículo científico publicado en 2007

Natural killer cells: From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture)

scientific article published on 01 April 2019

Neuroradiologic findings and follow‐up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement

artículo científico publicado el 21 de noviembre de 2011

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

artículo científico publicado en 2017

Ovine CD16+/CD14- blood lymphocytes present all the major characteristics of natural killer cells

artículo científico publicado en 2009

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis

artículo científico publicado en 2005

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding

artículo científico publicado en 2014

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

scientific article published on 05 August 2020

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

artículo científico publicado en 2007

Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function

scientific article published on 01 August 2019

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

artículo científico publicado en 2010

Surface NK receptors and their ligands on tumor cells

artículo científico publicado en 2006

Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells

artículo científico publicado en 2009

The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin-Independent Ligand on Cancer Cells

artículo científico publicado en 2017

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction

artículo científico publicado en 2009

Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome

artículo científico publicado en 2013

XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

artículo científico publicado en 2014

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes

artículo científico publicado en 2015