Lista de obras -

A Key Role of Insulin Receptors in Memory

artículo científico publicado en 2015

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

artículo científico publicado en 2007

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

artículo científico publicado en 2010

Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons

artículo científico publicado en 2005

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

artículo científico publicado en 2018

Alzheimer's disease and insulin resistance: translating basic science into clinical applications

artículo científico publicado en 2013

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

artículo científico publicado en 2014

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

artículo científico publicado en 2007

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

artículo científico publicado en 2015

Amyloid beta oligomers induce impairment of neuronal insulin receptors

artículo científico publicado en 2007

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

artículo científico publicado en 2011

Amyloid-β oligomers induce differential gene expression in adult human brain slices

artículo científico publicado en 2012

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

artículo científico publicado en 2017

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

artículo científico publicado en 2010

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

artículo científico publicado en 2012

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

artículo científico publicado en 2018

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants

artículo científico publicado en 2019

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

artículo científico publicado en 2017

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

artículo científico publicado en 2014

Behavioral Abnormalities in Knockout and Humanized Tau Mice

artículo científico publicado en 2020

Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease

artículo científico publicado en 2002

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

artículo científico publicado en 2017

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

artículo científico

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

artículo científico publicado en 2016

Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease

scientific article published on 21 June 2020

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

artículo científico publicado en 2018

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

artículo científico publicado en 2017

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

artículo científico publicado en 2017

Connecting type 2 diabetes to Alzheimer's disease

artículo científico publicado en 2013

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

artículo científico publicado en 2016

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

artículo científico publicado en 2007

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

artículo científico publicado en 2019

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes

article

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

artículo científico publicado en 2009

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

scientific article published on 20 November 2019

Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure.

artículo científico publicado en 2004

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

artículo científico publicado en 2006

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

artículo científico publicado en 2018

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

artículo científico publicado en 2017

How does brain insulin resistance develop in Alzheimer's disease?

artículo científico

Impaired peripheral glucose homeostasis and Alzheimer's disease

artículo científico publicado en 2017

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

artículo científico

Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

artículo científico publicado en 2001

Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes

artículo científico publicado en 2019

Insulin Resistance in Alzheimer's Disease

scholarly article by Laís S S Ferreira et al published 2018 in Frontiers in Neuroscience

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

artículo científico publicado en 2020

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

artículo científico publicado en 2017

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

artículo científico publicado en 2013

Long-term consequences of the absence of leptin signaling in early life

artículo científico publicado en 2019

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

artículo científico publicado en 2013

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

artículo científico publicado en 2017

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches

artículo científico publicado en 2018

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

artículo científico publicado en 2018

Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins.

artículo científico publicado en 2006

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

artículo científico publicado en 2004

Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity

artículo científico publicado en 2006

Monoclonal antibodies that target pathological assemblies of Abeta

artículo científico publicado en 2006

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

artículo científico publicado en 2010

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice

artículo científico publicado en 2019

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound

artículo científico publicado en 2005

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

artículo científico

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

scientific article published on 01 March 2019

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

artículo científico publicado en 2017

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus

artículo científico publicado en 2006

Opportunities and challenges in developing relevant animal models for Alzheimer's disease

artículo científico publicado en 2016

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

artículo científico publicado en 2020

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

artículo científico publicado en 2009

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease

scientific article published on 12 May 2020

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

artículo científico publicado en 2017

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

scientific article published on 21 April 2020

Small molecule inhibitors of lysozyme amyloid aggregation

artículo científico publicado en 2006

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

artículo científico publicado en 2015

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration

artículo científico publicado en 2007

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

artículo científico publicado en 2007

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

artículo científico publicado en 2013

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

artículo científico publicado en 2004

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

artículo científico publicado en 2018

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies

scholarly article by Rafaella Araujo Gonçalves et al published 2019 in Frontiers in Cellular Neuroscience

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease

artículo científico publicado en 2018

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

artículo científico publicado en 2018

The effect of lumbar puncture on the neurodegeneration biomarker neurofilament light in macaque monkeys

artículo científico publicado en 2020

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models

artículo científico publicado en 2019

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

scientific article published on 05 September 2019

Lista de obras de

A Key Role of Insulin Receptors in Memory

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Alzheimer's disease and insulin resistance: translating basic science into clinical applications

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Amyloid beta oligomers induce impairment of neuronal insulin receptors

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

Amyloid-β oligomers induce differential gene expression in adult human brain slices

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

Behavioral Abnormalities in Knockout and Humanized Tau Mice

Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

Connecting type 2 diabetes to Alzheimer's disease

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure.

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

How does brain insulin resistance develop in Alzheimer's disease?

Impaired peripheral glucose homeostasis and Alzheimer's disease

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes

Insulin Resistance in Alzheimer's Disease

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

Long-term consequences of the absence of leptin signaling in early life

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins.

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity

Monoclonal antibodies that target pathological assemblies of Abeta

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus

Opportunities and challenges in developing relevant animal models for Alzheimer's disease

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

Small molecule inhibitors of lysozyme amyloid aggregation

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies