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A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

artículo científico publicado en 2014

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

artículo científico publicado en 2016

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

scientific article published on 31 July 2018

A community resource for paired genomic and metabolomic data mining

artículo científico publicado en 2021

A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A ⬇️

artículo científico publicado en 2002

A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds

artículo científico publicado en 2020

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

artículo científico publicado en 2020

A novel Dps-type protein from insect gut bacteria catalyses hydrolysis and synthesis of N-acyl amino acids

artículo científico publicado en 2007

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

artículo científico publicado en 2002

A roadmap for metagenomic enzyme discovery

publication published on 17 November 2021

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

artículo científico publicado en 2016

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases

artículo científico publicado en 2014

An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.

artículo científico publicado en 2016

An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA.

artículo científico publicado en 2017

An environmental bacterial taxon with a large and distinct metabolic repertoire

artículo científico publicado en 2014

An enzymatic domain for the formation of cyclic ethers in complex polyketides

artículo científico publicado en 2013

Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS.

artículo científico publicado en 2010

Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

artículo científico publicado en 2004

Anwendungen von Einzelzellmethoden in der mikrobiellen Naturstoffforschung

artículo científico publicado en 2021

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes ⬇️

artículo científico publicado el 1 de enero de 2011

Aquimarins, Peptide Antibiotics with Amino‐Modified C‐Termini from a Sponge‐Derived Aquimarina sp. Bacterium

Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

artículo científico publicado en 2018

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

artículo científico publicado en 2017

Automated structure prediction of trans-acyltransferase polyketide synthase products ⬇️

scientific article published on 15 July 2019

Bacteria-induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea

artículo científico publicado en 2019

Biosynthesis of furanocoumarins: mevalonate-independent prenylation of umbelliferone in Apium graveolens (Apiaceae)

Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways

artículo científico publicado en 2007

Biosynthesis of phenylnannolone A, a multidrug resistance reversal agent from the halotolerant myxobacterium Nannocystis pusilla B150. ⬇️

artículo científico publicado en 2014

Biosynthesis of polyketides by trans-AT polyketide synthases

scientific article published on 12 May 2010

Biosynthesis of polyketides by trans-AT polyketide synthases

artículo científico

Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

artículo científico publicado en 2007

Biosynthesis of the myxobacterial antibiotic corallopyronin A.

artículo científico publicado en 2010

Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."

scientific article published on 07 May 2018

Biosynthetic origin of the antibiotic cyclocarbamate brabantamide A (SB-253514) in plant-associated Pseudomonas

artículo científico publicado en 2014

Biosynthetic potential of the global ocean microbiome

artículo científico publicado en 2022

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

scientific article published on 23 July 2018

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

artículo científico publicado en 2014

Characterization of an Orphan Type III Polyketide Synthase Conserved in Uncultivated "Entotheonella" Sponge Symbionts

artículo científico publicado en 2019

Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore.

artículo científico publicado en 2009

Combinatorial biosynthesis in symbiotic bacteria

scientific article published on 01 December 2006

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

artículo científico publicado en 2020

Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire

artículo científico publicado en 2014

Corrigendum: Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

artículo científico publicado en 2020

Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.

artículo científico publicado en 2017

Defense in the aeolidoidean genus Phyllodesmium (Gastropoda).

artículo científico publicado en 2014

Defensive bacteriome symbiont with a drastically reduced genome.

artículo científico publicado en 2013

Distribution and diversity of ‘Tectomicrobia’, a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites

artículo científico publicado en 2023

Effect of tolytoxin on tunneling nanotube formation and function

artículo científico publicado en 2019

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

scientific article published on 26 January 2022

Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production

artículo científico publicado en 2017

Enzyme from an Uncultivated Sponge Bacterium Catalyzes S-Methylation in a Ribosomal Peptide.

artículo científico publicado en 2016

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

artículo científico publicado en 2019

Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles ⬇️

artículo científico publicado en 2004

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria ⬇️

artículo científico publicado en 2021

Evolution-guided engineering of <i>trans</i> -acyltransferase polyketide synthases

artículo científico publicado en 2024

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

artículo científico publicado en 2008

Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family

artículo científico publicado en 2005

Expression of the Lantibiotic Mersacidin in Bacillus amyloliquefaciens FZB42 ⬇️

artículo científico publicado el 21 de julio de 2011

Fe2+ chelator proferrorosamine A: a gene cluster of Erwinia rhapontici P45 involved in its synthesis and its impact on growth of Erwinia amylovora CFBP1430.

artículo científico publicado en 2016

Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla

artículo científico publicado en 2002

Genome Mining Reveals trans‐AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes ⬇️

artículo científico publicado el 10 de diciembre de 2010

Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides ⬇️

artículo científico publicado en 2020

Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics

Genome mining- and synthetic biology-enabled production of hypermodified peptides ⬇️

artículo científico publicado en 2019

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

article

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

scientific article published on 19 July 2018

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

Genomic insights into the marine sponge microbiome

artículo científico publicado en 2012

Habitat-specific type I polyketide synthases in soils and street sediments

artículo científico publicado en 2013

Heterologe Expression, Biosynthese und ökologische Funktion des selektiven Gq‐Signaltransduktionsinhibitors FR900359

artículo científico publicado en 2017

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

artículo científico publicado en 2017

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

artículo científico publicado en 2017

Identification of trans ‐AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors ⬇️

artículo científico publicado en 2021

In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids

scientific article published on 04 February 2019

Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite.

artículo científico publicado en 2011

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.

artículo científico publicado en 2017

Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase

artículo científico publicado en 2019

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

scientific article published on 09 January 2019

Landornamides, antiviral ornithine-containing ribosomal peptides discovered by proteusin mining

scientific article published on 12 March 2020

Linking chemical and microbial diversity in marine sponges: possible role for poribacteria as producers of methyl-branched fatty acids

artículo científico publicado en 2010

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

artículo científico publicado en 2024

Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.

artículo científico publicado en 2013

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

artículo científico publicado en 2015

Metabolic footprint of epiphytic bacteria on Arabidopsis thaliana leaves

artículo científico publicado en 2015

Metabolites from symbiotic bacteria

artículo científico publicado en 2004

Metabolites from symbiotic bacteria

scientific article published on 05 December 2008

Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides

artículo científico publicado en 2012

Metagenomic Approaches to Identify and Isolate Bioactive Natural Products from Microbiota of Marine Sponges ⬇️

artículo científico publicado el 1 de enero de 2010

Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology.

artículo científico publicado en 2013

Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses. ⬇️

artículo científico publicado en 2013

Mevalonate-Independent Biosynthesis of Terpenoid Volatiles in Plants: Induced and Constitutive Emission of Volatiles

artículo científico publicado en 1998

Minimum Information about a Biosynthetic Gene cluster.

artículo científico publicado en 2015

Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

artículo científico publicado en 2022

Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster

scientific article published on 26 July 2002

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

artículo científico publicado en 2018

Natural products via enzymatic reactions. Preface.

artículo científico publicado en 2010

New developments in RiPP discovery, enzymology and engineering

scientific article published on 16 September 2020

Opening up the Single-Cell Toolbox for Microbial Natural Products Research

scientific article published on 12 February 2019

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis†Electronic supplementary information (ESI) available: Containing all experimental details. See DOI: 10.1039/c3sc52911hClick here for additional data file

artículo científico publicado en 2013

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

artículo científico publicado en 2018

Pederin-type pathways of uncultivated bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.

artículo científico publicado en 2009

Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale

artículo científico publicado en 2015

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

artículo científico publicado en 2014

Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone

artículo científico publicado en 2002

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

artículo científico publicado en 2009

Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.

artículo científico publicado en 2013

Polyketide proofreading by an acyltransferase-like enzyme

artículo científico publicado en 2012

Polyketide synthases of bacterial symbionts in sponges--evolution-based applications in natural products research

artículo científico publicado en 2009

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria

artículo científico publicado en 2015

Posttranslational arginases provide a ribosomal route to non-proteinogenic ornithine residues in diverse peptide sequences

artículo científico publicado en 2020

Promiscuous Installation of d-Amino Acids in Gene-Encoded Peptides

artículo científico publicado en 2021

Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of d-Amino Acid Products

artículo científico publicado en 2018

Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products

artículo científico publicado en 2014

Rapid isolation of rare clones from highly complex DNA libraries by PCR analysis of liquid gel pools.

artículo científico publicado en 2006

Recent advances in genome-based polyketide discovery.

artículo científico

Reciprocal cross talk between fatty acid and antibiotic biosynthesis in a nematode symbiont

artículo científico publicado en 2012

Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger

artículo científico publicado en 2012

Ribosomally derived lipopeptides containing distinct fatty acyl moieties

artículo científico publicado en 2022

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

artículo científico publicado en 2016

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

artículo científico publicado en 2016

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts ⬇️

artículo científico publicado en 2018

Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges

artículo científico publicado en 2011

Single-cell metabolite detection and genomics reveals uncultivated talented producer

Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast Metschnikowia pulcherrima

scientific article published on 20 May 2019

Soaking it up: the complex lives of marine sponges and their microbial associates

artículo científico publicado en 2007

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

artículo científico publicado en 2022

Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line

artículo científico publicado en 2018

Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. ⬇️

artículo científico publicado en 2006

Substrate specificity in ketosynthase domains from trans-AT polyketide synthases

artículo científico publicado en 2012

Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS

artículo científico publicado en 2011

Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A

artículo científico publicado en 2020

Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

artículo científico publicado en 2004

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

scientific article published on 25 March 2020

The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli

artículo científico publicado en 2016

The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules

artículo científico publicado en 2011

The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for β,γ Dehydration by a trans-Acyltransferase Polyketide Synthase

artículo científico publicado en 2010

The New Metabolite (S)-Cinnamoylphosphoramide fromStreptomycessp. and Its Total Synthesis

scientific article published on 09 September 2008

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

scientific article published on 02 October 2019

The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis

artículo científico publicado en 2013

The hidden enzymology of bacterial natural product biosynthesis

artículo científico publicado en 2019

Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria. ⬇️

artículo científico publicado en 2017

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. ⬇️

artículo científico publicado en 2018

Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase

artículo científico publicado en 2004

Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties

artículo científico publicado en 2008

Widespread Microbial Utilization of Ribosomal β-Amino Acid-Containing Peptides and Proteins

artículo científico publicado en 2022

Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins

artículo científico publicado en 2022

Widespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine sponges

artículo científico publicado en 2007

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