Filtros de búsqueda

Lista de obras de

24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex

artículo científico publicado en 2014

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

scientific article published on 10 February 2014

A 17q12 allele is associated with altered NK cell subsets and function.

artículo científico publicado en 2012

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

artículo científico publicado en 2018

A High-Density Admixture Map for Disease Gene Discovery in African Americans

artículo científico publicado en 2004

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

artículo científico publicado en 2015

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

artículo científico publicado en 2016

A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline

artículo científico publicado en 2012

A common polymorphism near PER1 and the timing of human behavioral rhythms

artículo científico publicado en 2012

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genome-wide association study of aging

artículo científico publicado en 2011

A genome-wide association study of depressive symptoms

scientific journal article

A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease.

artículo científico

A genome-wide scan for common variants affecting the rate of age-related cognitive decline

artículo científico publicado en 2011

A high-density screen for linkage in multiple sclerosis

artículo científico publicado en 2005

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

artículo científico publicado en 2017

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

artículo científico publicado en 2010

A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

artículo científico publicado en 2014

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

article

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

artículo científico publicado en 2018

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity

artículo científico publicado en 2015

A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis

artículo científico publicado en 2010

A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment

artículo científico publicado en 2012

A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks

scientific article published in Nature Communications

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

scientific article published on 01 August 2020

A second major histocompatibility complex susceptibility locus for multiple sclerosis

artículo científico publicado en 2007

A transcriptomic atlas of aged human microglia.

artículo científico publicado en 2018

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

artículo científico publicado en 2005

APOE and cerebral amyloid angiopathy in community-dwelling older persons

artículo científico publicado en 2015

APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults

scientific article published on 11 May 2018

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans

artículo científico publicado en 2017

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease

scientific article published on 05 November 2019

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

artículo científico publicado en 2007

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

artículo científico publicado en 2013

Allelic variant in CTLA4 alters T cell phosphorylation patterns

artículo científico publicado en 2007

Alterations of the human gut microbiome in multiple sclerosis.

artículo científico publicado en 2016

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer disease susceptibility loci: evidence for a protein network under natural selection

artículo científico publicado en 2012

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

artículo científico publicado en 2014

Alzheimer's loci: epigenetic associations and interaction with genetic factors

artículo científico publicado en 2015

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

artículo científico publicado en 2016

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

artículo científico publicado en 2012

An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.

artículo científico publicado en 2019

An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome

artículo científico publicado en 2013

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

artículo científico publicado en 2017

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

scientific article published on 10 June 2019

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

artículo científico publicado en 2013

Analysis of shared heritability in common disorders of the brain

artículo científico publicado en 2018

Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells

artículo científico publicado en 2013

Applying a new generation of genetic maps to understand human inflammatory disease

artículo científico publicado en 2005

Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members

artículo científico

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

artículo científico publicado en 2017

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

scientific article published on 22 June 2020

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

artículo científico publicado en 2005

Association between DNA methylation levels in brain tissue and late-life depression in community-based participants

artículo científico publicado en 2020

Association of APOE with tau-tangle pathology with and without β-amyloid

artículo científico publicado en 2015

Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease

artículo científico publicado en 2015

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

artículo científico publicado en 2010

Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease

scientific article published on 01 July 2019

Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies

artículo científico publicado en 2015

Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

artículo científico publicado en 2015

Association of Parkinson disease risk loci with mild parkinsonian signs in older persons

artículo científico publicado en 2014

Association of Social Network Structure and Physical Function in Patients With Multiple Sclerosis

artículo científico publicado en 2020

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

artículo científico publicado en 2021

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Molecular estimation of neurodegeneration pseudotime in older brains

artículo científico publicado en 2020

Author Correction: Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 November 2020

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Automated high-dimensional flow cytometric data analysis

artículo científico publicado en 2009

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

scientific article published on 29 July 2020

Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics

scientific article published on 10 September 2020

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks

scientific article published on 07 April 2020

Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes

artículo científico publicado en 2014

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease

scientific article published on 22 July 2019

Brain microRNAs are associated with variation in cognitive trajectory in advanced age

artículo científico publicado en 2022

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

scientific article published on 06 February 2020

Brain proteome-wide association study implicates novel proteins in depression pathogenesis

artículo científico publicado en 2021

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

artículo científico publicado en 2014

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

artículo científico publicado en 2013

CD33 modulates TREM2: convergence of Alzheimer loci.

artículo científico publicado en 2015

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

scientific article published on 30 December 2013

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

artículo científico publicado en 2010

CR1 is associated with amyloid plaque burden and age-related cognitive decline

artículo científico publicado en 2011

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis

article

Cerebral small vessel disease genomics and its implications across the lifespan

artículo científico publicado en 2020

Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.

artículo científico publicado en 2016

Charting a dynamic DNA methylation landscape of the human genome

artículo científico publicado en 2013

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.

artículo científico publicado en 2016

Class II HLA interactions modulate genetic risk for multiple sclerosis

artículo científico publicado en 2015

Classifying multiple sclerosis patients on the basis of SDMT performance using machine learning

artículo científico publicado en 2020

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

artículo científico publicado en 2013

Cognition may link cortical IGFBP5 levels with motor function in older adults

artículo científico publicado en 2019

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

artículo científico publicado en 2014

Common risk alleles for inflammatory diseases are targets of recent positive selection

artículo científico publicado en 2013

Common variants at 12q14 and 12q24 are associated with hippocampal volume

artículo científico publicado en 2012

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

artículo científico publicado en 2011

Common variants in DRD2 are associated with sleep duration: the CARe consortium

artículo científico publicado en 2015

Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis

artículo científico publicado en 2018

Complex Neurological Phenotype in Female Carriers of NHE6 Mutations

scientific article published on 06 March 2019

Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset

artículo científico publicado en 2016

Considerations for integrative multi-omic approaches to explore Alzheimer's disease mechanisms

scientific article published on 12 July 2020

Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups

scientific article published on 15 January 2019

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

artículo científico publicado en 2017

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

artículo científico publicado en 2016

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

artículo científico publicado en 2020

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease

artículo científico publicado en 2019

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

scientific article published on 01 September 2020

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

artículo científico publicado en 2008

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

artículo científico publicado en 2009

Deconstructing and targeting the genomic architecture of human neurodegeneration

scientific article published on 26 September 2018

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

scientific article published on 17 August 2020

Defining the role of the MHC in autoimmunity: a review and pooled analysis

artículo científico publicado en 2008

Designing an epigenomic study

artículo científico publicado en 2018

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

artículo científico publicado en 2017

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease

artículo científico publicado en 2017

Early complement genes are associated with visual system degeneration in multiple sclerosis

artículo científico publicado en 2019

Early elevation of serum tumor necrosis factor-α is associated with poor outcome in subarachnoid hemorrhage

artículo científico publicado en 2012

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

artículo científico publicado en 2014

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

article

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

article

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

artículo científico publicado en 2018

Epigenomics in translational research

artículo científico publicado en 2014

Epigenomics of Alzheimer's disease

artículo científico publicado en 2014

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

Erratum: Multicolored stain-free histopathology with coherent Raman imaging

scholarly article published in Laboratory Investigation

Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis

artículo científico publicado en 2015

Evaluating the role of genetic variation in the epigenome in health and disease

artículo científico publicado en 2018

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

artículo científico publicado en 2006

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

artículo científico publicado en 2016

Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course

artículo científico publicado en 2013

Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals

artículo científico publicado en 2010

Evidence for a common pathway linking neurodegenerative diseases.

artículo científico publicado en 2009

Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

artículo científico publicado en 2020

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

artículo científico publicado en 2015

Exploring the role of the epigenome in multiple sclerosis: a window onto cell-specific transcriptional potential

artículo científico

Fatal COVID-19 in an MS patient on natalizumab: A case report

scientific article published on 01 July 2020

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects

artículo científico publicado en 2013

Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach

artículo científico publicado en 2008

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

artículo científico publicado en 2013

Functional screening of Alzheimer pathology genome-wide association signals in Drosophila

artículo científico publicado en 2011

Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis

artículo científico publicado en 2014

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

artículo científico publicado en 2010

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

artículo científico publicado en 2016

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

artículo científico publicado en 2013

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

artículo científico publicado en 2013

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

artículo científico publicado en 2014

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

artículo científico publicado en 2015

Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics

artículo científico publicado en 2019

Gene expression elucidates functional impact of polygenic risk for schizophrenia

artículo científico publicado en 2016

Gene expression profiling in MS: what is the clinical relevance?

artículo científico publicado en 2004

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

artículo científico publicado en 2014

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk

artículo científico publicado en 2015

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines

artículo científico publicado en 2008

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection

Genetic and epigenetic fine mapping of causal autoimmune disease variants

artículo científico publicado en 2015

Genetic and gene expression signatures in multiple sclerosis

artículo científico publicado en 2020

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic architecture of age-related cognitive decline in African Americans

scientific article published on 21 December 2016

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

artículo científico publicado en 2018

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

scientific article published on 09 July 2018

Genetic diversity is a predictor of mortality in humans

artículo científico publicado en 2014

Genetic epistasis regulates amyloid deposition in resilient aging

artículo científico publicado en 2017

Genetic influence of plasma homocysteine on Alzheimer's disease.

artículo científico publicado en 2017

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

artículo científico publicado en 2019

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

artículo científico publicado en 2011

Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults

scientific article published on 03 October 2019

Genetic risk variants in African Americans with multiple sclerosis

artículo científico publicado en 2013

Genetic susceptibility for Alzheimer disease neuritic plaque pathology

artículo científico publicado en 2013

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

artículo científico publicado en 2016

Genetic variants in Alzheimer disease - molecular and brain network approaches

artículo científico publicado en 2016

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

artículo científico publicado en 2010

Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus.

artículo científico publicado en 2006

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

scientific article published on 08 June 2020

Genetics of rheumatoid arthritis contributes to biology and drug discovery

artículo científico publicado en 2013

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.

artículo científico publicado en 2016

Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults

artículo científico publicado en 2015

Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery

artículo científico publicado en 2011

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias

artículo científico publicado en 2014

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria

artículo científico publicado en 2019

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis

artículo científico publicado en 2013

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

artículo científico publicado en 2017

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

artículo científico publicado en 2010

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

artículo científico publicado en 2010

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

artículo científico publicado en 2018

Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

artículo científico publicado en 2013

Genome-wide chromatin state transitions associated with developmental and environmental cues

artículo científico publicado en 2013

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease

scientific article published on 29 April 2020

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

artículo científico publicado en 2015

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

artículo científico publicado en 2011

Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk

artículo científico publicado en 2015

HLA-C levels impact natural killer cell subset distribution and function.

artículo científico publicado en 2016

HLA-DRB1*1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis

artículo científico publicado en 2009

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

artículo científico publicado en 2012

Higher brain BDNF gene expression is associated with slower cognitive decline in older adults

artículo científico publicado en 2016

How do we measure the epigenome(s)?

scientific article published on 01 April 2018

Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts

scientific article published on 23 January 2020

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

artículo científico publicado en 2013

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

artículo científico publicado en 2009

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

artículo científico publicado en 2017

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

artículo científico publicado en 2021

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

artículo científico

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

artículo científico publicado en 2020

Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

artículo científico publicado en 2018

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease

artículo científico publicado en 2019

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

scientific article published on 28 January 2021

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

artículo científico publicado en 2009

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene

artículo científico publicado en 2014

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility

artículo científico publicado en 2018

Interindividual variation in human T regulatory cells

artículo científico publicado en 2014

Intermediate phenotypes identify divergent pathways to Alzheimer's disease

artículo científico publicado en 2010

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex

artículo científico publicado en 2011

Is the goal of an epigenomic study to determine causality?

artículo científico publicado en 2018

Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

artículo científico publicado en 2010

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

scientific article published on 12 October 2020

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

artículo científico publicado en 2022

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

artículo científico publicado en 2020

Life extension factor klotho enhances cognition

artículo científico publicado en 2014

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

artículo científico publicado en 2017

Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex.

artículo científico publicado en 2018

Low frequency and rare coding variation contributes to multiple sclerosis risk

MS AHI1 genetic risk promotes IFNγ+ CD4+ T cells

artículo científico publicado en 2017

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

artículo científico publicado en 2009

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

scientific article published on 01 July 2020

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

artículo científico publicado en 2009

Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology

artículo científico publicado en 2016

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

artículo científico publicado en 2014

Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline

artículo científico publicado en 2019

Modeling disease severity in multiple sclerosis using electronic health records

artículo científico publicado en 2013

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

artículo científico publicado en 2011

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA

artículo científico publicado en 2009

Molecular estimation of neurodegeneration pseudotime in older brains

artículo científico publicado en 2020

Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline

article

Multicolored stain-free histopathology with coherent Raman imaging.

artículo científico publicado en 2012

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

artículo científico publicado en 2015

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies

artículo científico publicado en 2016

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

artículo científico publicado en 2016

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline

artículo científico publicado en 2017

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles

artículo científico publicado en 2009

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

scientific article published in Nature Communications

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

artículo científico publicado en 2015

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

New therapeutic approaches for multiple sclerosis

artículo científico publicado en 2007

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

artículo científico publicado en 2013

No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50

artículo científico publicado en 2013

Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease

artículo científico publicado en 2013

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

artículo científico publicado en 2016

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

artículo científico publicado en 2012

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 July 2019

OR.102. The CD58 Pathway is Implicated in MS Susceptibility

Parkinson's Disease: Genetics and Pathogenesis ⬇️

artículo científico publicado el 1 de enero de 2011

Parsing the Interferon Transcriptional Network and Its Disease Associations

artículo científico publicado en 2016

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

Peripheral serum metabolomic profiles inform central cognitive impairment

artículo científico publicado en 2020

Personality Polygenes, Positive Affect, and Life Satisfaction

artículo científico publicado en 2016

Pervasive sharing of genetic effects in autoimmune disease

artículo científico publicado en 2011

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

artículo científico publicado en 2013

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

artículo científico publicado en 2014

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

artículo científico publicado en 2018

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

artículo científico publicado en 2016

Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments

scientific article published on 27 November 2010

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

artículo científico publicado en 2017

Re: GAMES issue study: Are international genetic consortia functional?

artículo científico publicado en 2004

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells

artículo científico publicado en 2014

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

artículo científico publicado en 2016

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

scientific article published on 18 March 2009

Reply to Brynedal et al.: Accumulating genetic and functional evidence for a role of in multiple sclerosis

artículo científico publicado en 2009

Reply: To PMID 25545807.

artículo científico publicado en 2015

Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex ⬇️

artículo científico publicado en 2018

Review: Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the future ⬇️

artículo científico publicado el 1 de noviembre de 2009

Rituximab for tumefactive inflammatory demyelination: a case report

artículo científico publicado en 2012

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts

scientific article published on 04 September 2018

Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis

artículo científico publicado en 2017

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

artículo científico publicado en 2007

Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex

scientific article published on April 2013

Sex differences in the genetic predictors of Alzheimer's pathology

scientific article published on 01 September 2019

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

scientific article published on 01 August 2018

Sex-specific genetic predictors of Alzheimer's disease biomarkers

artículo científico publicado en 2018

Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes

artículo científico publicado en 2020

Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis

artículo científico publicado en 2013

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease

artículo científico publicado en 2020

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

artículo científico publicado en 2016

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

artículo científico publicado en 2017

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia

scientific article published on 11 December 2019

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses

artículo científico publicado en 2009

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

artículo científico publicado en 2018

Switching from natalizumab to ocrelizumab in patients with multiple sclerosis

scientific article published on 19 June 2020

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

artículo científico publicado en 2019

TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer's Disease

artículo científico publicado en 2012

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype

artículo científico

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

scholarly article by Lei Yu et al published July 2018 in Annals of Neurology

Tau Activates Transposable Elements in Alzheimer's Disease

artículo científico publicado en 2018

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease

scientific article published on 01 October 2019

Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

scholarly article published 9 January 2019

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

artículo científico publicado en 2017

The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation

artículo científico publicado en 2011

The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease

artículo científico publicado en 2011

The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis

scientific article published on 20 March 2019

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

scholarly article by Shinya Tasaki et al published 2018 in Frontiers in Neuroscience

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

scholarly article published 13 July 2017

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults

artículo científico publicado en 2016

The TMEM106B locus and TDP-43 pathology in older persons without FTLD

artículo científico publicado en 2015

The association of magnetic resonance imaging measures with cognitive function in a biracial population sample

artículo científico publicado en 2010

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The educational impact of childhood-onset multiple sclerosis: Why assessing academic achievement is imperative

artículo científico publicado en 2020

The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

artículo científico publicado en 2016

The era of GWAS is over - No.

artículo científico publicado en 2017

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages

artículo científico publicado en 2020

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

scientific article published on 12 August 2019

The power of genetic diversity in genome-wide association studies of lipids

The role of the CD58 locus in multiple sclerosis

artículo científico publicado en 2009

The transcriptional landscape of age in human peripheral blood

artículo científico publicado en 2015

Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci

artículo científico publicado en 2016

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

artículo científico publicado en 2017

Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans

artículo científico publicado en 2020

UNC5C variants are associated with cerebral amyloid angiopathy

artículo científico publicado en 2017

Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease

artículo científico publicado en 2017

Uncovering the Role of the Methylome in Dementia and Neurodegeneration

artículo científico publicado en 2016

Uncovering the genetic architecture of multiple sclerosis.

artículo científico publicado en 2010

Uncovering the genetic architecture of white matter disease

artículo científico publicado en 2011

Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

artículo científico publicado en 2009

Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain

scientific article published on 22 August 2019

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

artículo científico publicado en 2013

Variation within DNA repair pathway genes and risk of multiple sclerosis

artículo científico publicado en 2010

What is the epigenome and is it involved in multiple sclerosis?

artículo científico publicado en 2018

cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

scientific article published on 01 August 2019

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda