Lista de obras -

1-Methyl-1<i>H</i>-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

scientific article published on 22 December 2020

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

artículo científico publicado en 2019

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity

artículo científico publicado en 2010

A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting

artículo científico publicado en 2014

A practical Java tool for small-molecule compound appraisal

artículo científico publicado en 2015

Action plan for hit identification (APHID): KAT6A as a case study

scientific article published on 17 February 2020

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

artículo científico publicado en 2010

Ask the experts: past, present and future of the rule of five

artículo científico publicado en 2013

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

artículo científico publicado en 2017

Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350,000 Compounds ⬇️

artículo científico publicado el 17 de diciembre de 2012

Chemistry: Chemical con artists foil drug discovery

artículo científico publicado en 2014

Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.

artículo científico publicado en 2018

Crystal structure of the M5 muscarinic acetylcholine receptor

scientific article published on 26 November 2019

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

artículo científico publicado en 2015

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

artículo científico publicado en 2017

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

artículo científico publicado en 2020

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

artículo científico publicado en 2020

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

scientific article published on 17 July 2019

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

artículo científico publicado en 2013

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

artículo científico publicado en 2021

Erratum: Corrigendum: The promise and peril of chemical probes

artículo científico publicado en 2015

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

artículo científico publicado en 2017

Histone acetyltransferase inhibitors: where art thou?

artículo científico publicado en 2016

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

artículo científico publicado en 2016

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

artículo científico publicado en 2014

I2-Promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones: facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines

artículo científico publicado en 2020

Inhibition studies of sulfonamide-containing folate analogs in yeast

artículo científico publicado en 2003

Low cost whole-organism screening of compounds for anthelmintic activity.

artículo científico publicado en 2015

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity

artículo científico publicado en 2019

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

artículo científico publicado en 2013

Nuisance compounds in cellular assays

artículo científico publicado en 2021

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

artículo científico publicado en 2016

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

artículo científico publicado en 2017

Optimization of Novel 1-Methyl-1H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

artículo científico publicado en 2018

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

artículo científico publicado en 2011

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

artículo científico publicado en 2016

Reviewing hit discovery literature for difficult targets: glutathione transferase omega-1 as an example.

artículo científico publicado en 2018

Screening-based translation of public research encounters painful problems

artículo científico publicado en 2015

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

artículo científico publicado en 2016

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

artículo científico publicado en 2016

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.

artículo científico publicado en 2017

Sites of action of ghrelin receptor ligands in cardiovascular control

artículo científico publicado en 2012

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

artículo científico publicado en 2013

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

article

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

scientific article published on 13 May 2019

The promise and peril of chemical probes

artículo científico publicado en 2015

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

artículo científico publicado en 2009

Lista de obras de

1-Methyl-1<i>H</i>-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity

A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting

A practical Java tool for small-molecule compound appraisal

Action plan for hit identification (APHID): KAT6A as a case study

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

Ask the experts: past, present and future of the rule of five

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350,000 Compounds ⬇️

Chemistry: Chemical con artists foil drug discovery

Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.

Crystal structure of the M5 muscarinic acetylcholine receptor

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

Erratum: Corrigendum: The promise and peril of chemical probes

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Histone acetyltransferase inhibitors: where art thou?

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

I2-Promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones: facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines

Inhibition studies of sulfonamide-containing folate analogs in yeast

Low cost whole-organism screening of compounds for anthelmintic activity.

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Nuisance compounds in cellular assays

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Optimization of Novel 1-Methyl-1H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Reviewing hit discovery literature for difficult targets: glutathione transferase omega-1 as an example.

Screening-based translation of public research encounters painful problems

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.

Sites of action of ghrelin receptor ligands in cardiovascular control

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

The promise and peril of chemical probes

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity