Lista de obras -

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia

artículo científico publicado en 2016

11β-Hydroxysteroid dehydrogenase type 2 in hypertension: comparison of phenotype and genotype analysis

artículo científico publicado en 2013

Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance

artículo científico publicado en 2015

Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins

scientific article published on 01 July 2018

Bioavailability of gliclazide from some formulation tablets

artículo científico publicado en 1998

Bioavailability of mesalazine from two coated formulation tablets

artículo científico publicado en 2019

Bioavailability of moclobemide from two formulation tablets in healthy humans

scientific article published on 01 February 2019

Bioavailability of propylthiouracil from two formulation tablets

scientific article published on 01 December 2018

Bupivacaine administered intrathecally versus rectally in the management of intractable rectal cancer pain in palliative care

artículo científico publicado en 2014

CE Determination of Ketoprofen Enantiomers in Clinical Samples of Plasma, Synovial Fluid and Urine

artículo científico publicado en 2008

Capillary zone electrophoresis method for determination of (+)-S clopidogrel carboxylic acid metabolite in human plasma and urine designed for biopharmaceutic studies

artículo científico publicado en 2010

Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results.

artículo científico publicado en 2018

Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases

artículo científico publicado en 2014

Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis

artículo científico publicado en 2011

Correction to: Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

artículo científico publicado en 2020

Cortisol metabolism in pregnancies with small for gestational age neonates

scientific article published on 29 November 2019

DISSOLUTION KINETICS STUDIES OF CLOPIDOGREL FROM SELECTED MULTISOURCE COATED TABLETS WITH APPLICATION OF CAPILLARY ZONE ELECTROPHORESIS METHOD.

artículo científico publicado en 2016

Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS.

artículo científico publicado en 2017

Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays

artículo científico publicado en 2017

Determination of ketoprofen enantiomers in human serum by capillary zone electrophoresis: man pharmacokinetic studies after administration of rac-ketoprofen tablets

artículo científico publicado en 2002

Determination of partition coefficients n-octanol/water for treosulfan and its epoxy-transformers: An example of a negative correlation between lipophilicity of unionized compounds and their retention in reversed-phase chromatography ⬇️

artículo científico publicado el 19 de febrero de 2013

Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method

artículo científico publicado en 2017

Determination of roxithromycin in human plasma by HPLC with fluorescence and UV absorbance detection: application to a pharmacokinetic study

scientific article published on 20 February 2007

Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring

scientific article published on 25 October 2019

Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation

scientific article published on 22 December 2006

Development of a Limited Sampling Strategy for the Estimation of Exposure to High-Dose Etoposide After Intravenous Infusion in Pediatric Patients.

artículo científico publicado en 2016

Development of an LC-MS/MS method for simultaneous determination of ticagrelor and its active metabolite during concomitant treatment with atorvastatin

artículo científico publicado en 2018

Direct high-performance liquid chromatography method with refractometric detection designed for stability studies of treosulfan and its biologically active epoxy-transformers.

artículo científico publicado en 2012

Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance.

artículo científico publicado en 2017

Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.

artículo científico publicado en 2017

Enantioselective CE method for pharmacokinetic studies on ibuprofen and its chiral metabolites with reference to genetic polymorphism

artículo científico publicado en 2007

FC33 dose-dependent first-order elimination of racemic ibuprofen in rabbits

artículo científico publicado en 1994

Formation Rate-Limited Pharmacokinetics of Biologically Active Epoxy Transformers of Prodrug Treosulfan

scientific article published on 01 April 2016

Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor

artículo científico publicado en 2018

Genetic and non-genetic factors affecting the response to clopidogrel therapy ⬇️

artículo científico publicado el 7 de marzo de 2012

Genetic factors influencing efficacy of clopidogrel treatment

artículo científico publicado en 2012

Glucocorticoid Metabolism in Hypertensive Disorders of Pregnancy: Analysis of Plasma and Urinary Cortisol and Cortisone.

artículo científico publicado en 2015

HPCE AND HPLC METHODS FOR DETERMINATION OF CLOPIDOGREL AND ITS CARBOXYLIC ACID METABOLITE IN BIOLOGICAL SAMPLES: A COMPARATIVE ANALYSIS

HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women

artículo científico publicado en 2021

HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application

artículo científico publicado en 2011

HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids

artículo científico publicado en 2009

HPLC–MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples

scientific article published on 12 November 2012

HSD11B2, RUNX3, and LINE-1 Methylation in Placental DNA of Hypertensive Disorders of Pregnancy Patients.

artículo científico publicado en 2017

High performance capillary electrophoresis for determination of the enantiomers of 2-arylpropionic acid derivatives in human serum. Pharmacokinetic studies of ketoprofen enantiomers following administration of standard and sustained release tablets.

artículo científico publicado en 2004

High performance capillary electrophoresis method for determination of ibuprofen enantiomers in human serum and urine

artículo científico publicado en 2005

High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation ⬇️

artículo científico publicado el 1 de octubre de 2010

High-performance liquid chromatography methods for the analysis of endogenous cortisol and cortisone in human urine: comparison of mass spectrometry and fluorescence detection

artículo científico publicado en 2018

Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel

artículo científico publicado en 2016

Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites

artículo científico publicado en 2014

Impact of genetic variants of selected cytochrome P450 isoenzymes on pharmacokinetics and pharmacodynamics of clopidogrel in patients co-treated with atorvastatin or rosuvastatin

scientific article published on 02 January 2020

In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione

scientific article published on 01 October 2019

In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats.

artículo científico publicado en 2018

Increased cortisol metabolism in women with pregnancy-related hypertension.

artículo científico publicado en 2018

Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.

artículo científico publicado en 2017

Influence of statin treatment on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites in patients after coronary angiography/angioplasty

artículo científico publicado en 2019

Kinetic and Mechanistic Study of the pH-Dependent Activation (Epoxidation) of Prodrug Treosulfan Including the Reaction Inhibition in a Borate Buffer

artículo científico publicado en 2017

Kinetics of in Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan

scientific article published on 03 May 2019

LC procedure with SPE for quantification of indobufen enantiomers: pharmacokinetic studies

scientific article published on 01 February 2000

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of three N-7-guanine adducts of the active epoxides of prodrug treosulfan in DNA in vitro

scientific article published on 08 February 2019

Lumbar paravertebral blockade as intractable pain management method in palliative care.

artículo científico publicado en 2013

Maternal Serum Endocan Concentration in Pregnancies Complicated by Intrauterine Growth Restriction

scientific article published on 09 May 2018

Measurement of plasma 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in population of patients with cardiovascular disease by UPLC-MS/MS method

artículo científico publicado en 2020

Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils.

artículo científico publicado en 2008

N-7-Guanine Adduct of the Active Monoepoxide of Prodrug Treosulfan: First Synthesis, Characterization, and Decomposition Profile Under Physiological Conditions

scientific article published on 27 June 2018

New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs)

artículo científico publicado en 2020

Ocular disposition of treosulfan and its active epoxy-transformers following intravenous administration in rabbits

artículo científico publicado en 2016

Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats.

artículo científico publicado en 2015

Pharmacokinetic Drug-Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients

artículo científico publicado en 2021

Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats

artículo científico publicado en 2020

Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes.

artículo científico publicado en 2009

Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.

artículo científico publicado en 2008

Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT.

artículo científico publicado en 2014

Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

artículo científico publicado en 2020

Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation.

artículo científico publicado en 2017

Protein binding of indobufen enantiomers: pharmacokinetics of free fraction-studies after single or multiple doses of rac-indobufen

artículo científico publicado en 2002

RP-HPLC method with fluorescence detection for determination of small quantities of triamcinolone in plasma in presence of endogenous steroids after derivatization with 9-anthroyl nitrile; pharmacokinetic studies

artículo científico publicado en 2006

Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of protein-free pro-drug treosulfan and its biologically active monoepoxy-transformer in plasma and brain tissue.

artículo científico publicado en 2014

Relationship between exposure to treosulfan and its monoepoxytransformer – An insight from population pharmacokinetic study in pediatric patients before hematopoietic stem cell transplantation

scientific article published on 27 April 2018

Reply to Comment on “Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation” by G. Hempel and

artículo científico publicado en 2007

Resolution of indobufen enantiomers by capillary zone electrophoresis. Pharmacokinetic studies of human serum.

artículo científico publicado en 2004

Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy

artículo científico publicado en 2018

Serum sCD25 Protein as a Predictor of Lack of Long-Term Benefits from Immunotherapy in Non-Small Cell Lung Cancer: A Pilot Study

artículo científico publicado en 2021

Steady-state pharmacokinetics of indobufen enantiomers in patients with obliterative atherosclerosis

artículo científico publicado en 2001

Stereoselective CZE method for analysis of verapamil and norverapamil in human plasma

artículo científico publicado el 1 de mayo de 2013

Stereoselective pharmacokinetics of ibuprofen and its lysinate from suppositories in rabbits

artículo científico publicado en 2000

Stereoselective pharmacokinetics of indobufen from tablets and intramuscular injections in man

artículo científico publicado en 2000

Studies on the metabolism of ibuprofen in isolated rat hepatocytes

scientific article published on 01 May 1997

The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles

artículo científico publicado en 2021

The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases

artículo científico publicado en 2014

Ticagrelor in modern cardiology - an up-to-date review of most important aspects of ticagrelor pharmacotherapy

artículo científico publicado en 2017

Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives.

artículo científico publicado en 2018

Variants of HSD11B2 gene in hypertensive disorders of pregnancy

artículo científico publicado en 2016

Vitamin D Receptor Gene Polymorphism and Vitamin D Status in Population of Patients with Cardiovascular Disease-A Preliminary Study

artículo científico publicado en 2021

[Biological availability of ibuprofen in Imbun 500 suppositories]

scientific article published on 01 January 1990

[The in vitro neutralizing efficacy of different dosage forms of antacid preparations]

artículo científico publicado en 1984

Lista de obras de

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia

11β-Hydroxysteroid dehydrogenase type 2 in hypertension: comparison of phenotype and genotype analysis

Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance

Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins

Bioavailability of gliclazide from some formulation tablets

Bioavailability of mesalazine from two coated formulation tablets

Bioavailability of moclobemide from two formulation tablets in healthy humans

Bioavailability of propylthiouracil from two formulation tablets

Bupivacaine administered intrathecally versus rectally in the management of intractable rectal cancer pain in palliative care

CE Determination of Ketoprofen Enantiomers in Clinical Samples of Plasma, Synovial Fluid and Urine

Capillary zone electrophoresis method for determination of (+)-S clopidogrel carboxylic acid metabolite in human plasma and urine designed for biopharmaceutic studies

Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results.

Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases

Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis

Correction to: Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

Cortisol metabolism in pregnancies with small for gestational age neonates

DISSOLUTION KINETICS STUDIES OF CLOPIDOGREL FROM SELECTED MULTISOURCE COATED TABLETS WITH APPLICATION OF CAPILLARY ZONE ELECTROPHORESIS METHOD.

Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS.

Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays

Determination of ketoprofen enantiomers in human serum by capillary zone electrophoresis: man pharmacokinetic studies after administration of rac-ketoprofen tablets

Determination of partition coefficients n-octanol/water for treosulfan and its epoxy-transformers: An example of a negative correlation between lipophilicity of unionized compounds and their retention in reversed-phase chromatography ⬇️

Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method

Determination of roxithromycin in human plasma by HPLC with fluorescence and UV absorbance detection: application to a pharmacokinetic study

Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring

Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation

Development of a Limited Sampling Strategy for the Estimation of Exposure to High-Dose Etoposide After Intravenous Infusion in Pediatric Patients.

Development of an LC-MS/MS method for simultaneous determination of ticagrelor and its active metabolite during concomitant treatment with atorvastatin

Direct high-performance liquid chromatography method with refractometric detection designed for stability studies of treosulfan and its biologically active epoxy-transformers.

Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance.

Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.

Enantioselective CE method for pharmacokinetic studies on ibuprofen and its chiral metabolites with reference to genetic polymorphism

FC33 dose-dependent first-order elimination of racemic ibuprofen in rabbits

Formation Rate-Limited Pharmacokinetics of Biologically Active Epoxy Transformers of Prodrug Treosulfan

Genetic Determinants of Vitamin D-Related Disorders; Focus on Vitamin D Receptor

Genetic and non-genetic factors affecting the response to clopidogrel therapy ⬇️

Genetic factors influencing efficacy of clopidogrel treatment

Glucocorticoid Metabolism in Hypertensive Disorders of Pregnancy: Analysis of Plasma and Urinary Cortisol and Cortisone.

HPCE AND HPLC METHODS FOR DETERMINATION OF CLOPIDOGREL AND ITS CARBOXYLIC ACID METABOLITE IN BIOLOGICAL SAMPLES: A COMPARATIVE ANALYSIS

HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women

HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application

HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids

HPLC–MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples

HSD11B2, RUNX3, and LINE-1 Methylation in Placental DNA of Hypertensive Disorders of Pregnancy Patients.

High performance capillary electrophoresis for determination of the enantiomers of 2-arylpropionic acid derivatives in human serum. Pharmacokinetic studies of ketoprofen enantiomers following administration of standard and sustained release tablets.

High performance capillary electrophoresis method for determination of ibuprofen enantiomers in human serum and urine

High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation ⬇️

High-performance liquid chromatography methods for the analysis of endogenous cortisol and cortisone in human urine: comparison of mass spectrometry and fluorescence detection

Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel

Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites

Impact of genetic variants of selected cytochrome P450 isoenzymes on pharmacokinetics and pharmacodynamics of clopidogrel in patients co-treated with atorvastatin or rosuvastatin

In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione

In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats.

Increased cortisol metabolism in women with pregnancy-related hypertension.

Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.

Influence of statin treatment on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites in patients after coronary angiography/angioplasty

Kinetic and Mechanistic Study of the pH-Dependent Activation (Epoxidation) of Prodrug Treosulfan Including the Reaction Inhibition in a Borate Buffer

Kinetics of in Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan

LC procedure with SPE for quantification of indobufen enantiomers: pharmacokinetic studies

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of three N-7-guanine adducts of the active epoxides of prodrug treosulfan in DNA in vitro

Lumbar paravertebral blockade as intractable pain management method in palliative care.

Maternal Serum Endocan Concentration in Pregnancies Complicated by Intrauterine Growth Restriction

Measurement of plasma 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in population of patients with cardiovascular disease by UPLC-MS/MS method

Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils.

N-7-Guanine Adduct of the Active Monoepoxide of Prodrug Treosulfan: First Synthesis, Characterization, and Decomposition Profile Under Physiological Conditions

New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs)

Ocular disposition of treosulfan and its active epoxy-transformers following intravenous administration in rabbits

Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats.

Pharmacokinetic Drug-Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients

Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats

Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes.

Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.

Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT.

Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation.

Protein binding of indobufen enantiomers: pharmacokinetics of free fraction-studies after single or multiple doses of rac-indobufen

RP-HPLC method with fluorescence detection for determination of small quantities of triamcinolone in plasma in presence of endogenous steroids after derivatization with 9-anthroyl nitrile; pharmacokinetic studies

Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of protein-free pro-drug treosulfan and its biologically active monoepoxy-transformer in plasma and brain tissue.

Relationship between exposure to treosulfan and its monoepoxytransformer – An insight from population pharmacokinetic study in pediatric patients before hematopoietic stem cell transplantation

Reply to Comment on “Determination of treosulfan in plasma and urine by HPLC with refractometric detection; pharmacokinetic studies in children undergoing myeloablative treatment prior to haematopoietic stem cell transplantation” by G. Hempel and