Lista de obras -

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

artículo científico publicado en 2014

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

artículo científico publicado en 2003

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

artículo científico publicado en 2009

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

artículo científico publicado en 2015

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

artículo científico publicado en 2004

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

scholarly article

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism ⬇️

artículo científico publicado el 29 de junio de 2012

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

artículo científico publicado en 2014

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

artículo científico publicado en 2009

Contribution of GTPase activity to LRRK2-associated Parkinson disease

artículo científico publicado en 2013

Deciphering the role of VPS35 in Parkinson's disease.

artículo científico publicado en 2018

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

artículo científico publicado en 2020

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

artículo científico publicado en 2011

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

artículo científico publicado en 2007

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

artículo científico publicado en 2006

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

artículo científico publicado en 2014

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

artículo científico publicado en 2017

GTPase activity plays a key role in the pathobiology of LRRK2.

artículo científico publicado en 2010

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease

artículo científico publicado en 2016

LRRK2 secretion in exosomes is regulated by 14-3-3.

artículo científico publicado en 2013

Lessons from Drosophila models of DJ-1 deficiency

artículo científico publicado en 2006

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

artículo científico publicado en 2005

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

artículo científico publicado en 2006

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

artículo científico publicado en 2007

Mechanisms of LRRK2-Mediated Neurodegeneration ⬇️

artículo científico publicado el 1 de junio de 2012

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.

artículo científico publicado en 2017

Mitochondrial dysfunction in genetic animal models of Parkinson's disease

artículo científico publicado en 2011

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

artículo científico publicado en 2005

Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents

artículo científico publicado en 2015

Molecular pathophysiology of Parkinson's disease

artículo científico publicado en 2005

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

artículo científico publicado en 2012

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

scientific journal article

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

artículo científico publicado en 2009

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

artículo científico publicado en 2017

Parkin mediates the degradation-independent ubiquitination of Hsp70

artículo científico publicado en 2008

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

artículo científico publicado en 2018

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 ⬇️

artículo científico publicado el 6 de junio de 2011

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36 ⬇️

artículo científico publicado el 25 de agosto de 2011

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

artículo científico publicado en 2007

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

artículo científico publicado en 2005

Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

artículo científico publicado en 2019

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

artículo científico publicado en 2014

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

artículo científico publicado en 2019

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations

artículo científico publicado en 2012

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

artículo científico publicado en 2010

Revelations and revolutions in the understanding of Parkinson's disease.

artículo científico publicado en 2009

Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses

artículo científico publicado en 2003

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

artículo científico publicado en 2008

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

artículo científico publicado en 2019

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

artículo científico publicado en 2016

Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.

artículo científico publicado en 2017

VPS35, the Retromer Complex and Parkinson's Disease.

artículo científico publicado en 2017

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

artículo científico publicado en 2008

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

artículo científico publicado en 2012

α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).

artículo científico publicado en 2014

Lista de obras de

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism ⬇️

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

Contribution of GTPase activity to LRRK2-associated Parkinson disease

Deciphering the role of VPS35 in Parkinson's disease.

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

GTPase activity plays a key role in the pathobiology of LRRK2.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease

LRRK2 secretion in exosomes is regulated by 14-3-3.

Lessons from Drosophila models of DJ-1 deficiency

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

Mechanisms of LRRK2-Mediated Neurodegeneration ⬇️

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.

Mitochondrial dysfunction in genetic animal models of Parkinson's disease

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents

Molecular pathophysiology of Parkinson's disease

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

Parkin mediates the degradation-independent ubiquitination of Hsp70

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 ⬇️

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36 ⬇️

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

Revelations and revolutions in the understanding of Parkinson's disease.

Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.

VPS35, the Retromer Complex and Parkinson's Disease.

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).