Lista de obras -

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones - inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation ⬇️

artículo científico publicado el 1 de septiembre de 1991

2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph

artículo científico publicado en 2016

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

artículo científico publicado en 2019

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry ⬇️

artículo científico publicado el 2 de septiembre de 2010

Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres ⬇️

artículo científico publicado el 1 de agosto de 1995

Advances toward COVID-19 Therapies Special Issue Call for Papers

artículo científico publicado en 2020

Allosteric Modulators of Drug Targets Special Issue.

artículo científico publicado en 2018

Artificial Intelligence in Drug Discovery: Into the Great Wide Open

artículo científico publicado en 2020

Azetidin-2-one derivatives as inhibitors of thrombin ⬇️

artículo científico publicado el 1 de agosto de 1995

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

artículo científico publicado en 2017

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

artículo científico publicado en 2016

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.

artículo científico publicado en 2018

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.

artículo científico publicado en 2017

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir

scientific article published on 02 April 2019

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamet

article

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

artículo científico publicado en 2017

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

artículo científico publicado en 2017

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

scientific article published on 21 February 2020

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection

artículo científico publicado en 2014

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

artículo científico publicado en 2016

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase

artículo científico publicado en 2014

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

artículo científico publicado en 2016

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

artículo científico publicado en 2017

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

artículo científico publicado en 2020

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

scientific article published on 08 January 2019

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

artículo científico publicado en 2017

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors

scientific article published on 06 December 2018

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

artículo científico publicado en 2017

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir

article

Drug-target interactions that involve the replacement or displacement of magnesium ions.

artículo científico publicado en 2017

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

artículo científico publicado en 2018

Functionalized triazines as potent HCV entry inhibitors.

artículo científico publicado en 2016

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

artículo científico publicado en 2014

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

artículo científico publicado en 2016

Imidazoquinoline derivatives: Potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets ⬇️

artículo científico publicado el 1 de abril de 1991

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety ⬇️

artículo científico publicado el 26 de julio de 2011

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers ⬇️

artículo científico publicado el 6 de septiembre de 2011

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

artículo científico publicado en 2011

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

artículo científico publicado en 2017

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

artículo científico publicado en 2016

Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains

artículo científico publicado el 10 de julio de 1992

Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility

artículo científico publicado el 10 de julio de 1992

Introduction to hepatitis C virus (HCV) therapies special thematic issue

artículo científico publicado en 2014

Introduction: Drug Metabolism and Toxicology Special Issue

scientific article published on 02 June 2020

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016.

artículo científico publicado en 2016

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

artículo científico publicado en 2016

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

scientific article published on 17 March 2020

New first and second generation inhibitors of human immunodeficiency virus-1 integrase ⬇️

artículo científico publicado el 20 de mayo de 2011

Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives

artículo científico publicado el 18 de septiembre de 1992

Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

artículo científico publicado el 18 de septiembre de 1992

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

artículo científico publicado en 2020

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

artículo científico publicado en 2015

Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors

scientific article published on 05 November 2018

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic

artículo científico publicado el 24 de enero de 1992

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.

artículo científico publicado en 2016

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design ⬇️

artículo científico publicado el 17 de marzo de 2011

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

artículo científico publicado en 2020

The 2020 Nobel Prize in Physiology or Medicine

artículo científico publicado en 2020

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors ⬇️

artículo científico publicado en 2014

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

artículo científico publicado en 2018

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

artículo científico publicado en 2017

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

scientific article published on 08 February 2017

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection

artículo científico publicado en 2014

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

artículo científico publicado en 2020

Lista de obras de

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones - inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation ⬇️

2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry ⬇️

Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres ⬇️

Advances toward COVID-19 Therapies Special Issue Call for Papers

Allosteric Modulators of Drug Targets Special Issue.

Artificial Intelligence in Drug Discovery: Into the Great Wide Open

Azetidin-2-one derivatives as inhibitors of thrombin ⬇️

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamet

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir

Drug-target interactions that involve the replacement or displacement of magnesium ions.

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Functionalized triazines as potent HCV entry inhibitors.

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

Imidazoquinoline derivatives: Potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets ⬇️

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety ⬇️

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers ⬇️

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains

Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility

Introduction to hepatitis C virus (HCV) therapies special thematic issue

Introduction: Drug Metabolism and Toxicology Special Issue

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016.

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

New first and second generation inhibitors of human immunodeficiency virus-1 integrase ⬇️

Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives

Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design ⬇️

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

The 2020 Nobel Prize in Physiology or Medicine

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors ⬇️

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors