Lista de obras - Margaret A. Phillips - Dominio Público Uruguay

A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei

artículo científico publicado en 2011

A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool

artículo científico publicado en 2015

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

scientific article published on 26 October 2018

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

artículo científico publicado en 2015

A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes

artículo científico publicado en 2013

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

artículo científico publicado en 2016

Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics

artículo científico publicado en 2011

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

scientific journal article

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

artículo científico publicado en 2007

Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin

artículo científico publicado en 2020

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

artículo científico publicado en 2011

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae

artículo científico publicado en 2009

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

artículo científico publicado en 2008

Anticancer properties of distinct antimalarial drug classes

artículo científico publicado en 2013

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

article

Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications

artículo científico publicado en 2013

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

artículo científico publicado en 2018

Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor

artículo científico publicado en 2014

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

artículo científico publicado en 2012

Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels

artículo científico publicado en 2010

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

artículo científico publicado en 2008

Chemical genetics of Plasmodium falciparum

artículo científico publicado en 2010

Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme

artículo científico publicado en 2009

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins

artículo científico publicado en 2015

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.

artículo científico publicado en 2007

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

artículo científico publicado en 2009

Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase

artículo científico publicado en 2010

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis

artículo científico publicado en 2016

Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine

artículo científico publicado en 2010

Evolution of Substrate Specificity within a Diverse Family of / -Barrel-fold Basic Amino Acid Decarboxylases: X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE AND CARBOXYNORSPERMIDINE

artículo científico publicado en 2010

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

artículo científico publicado en 2014

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

artículo científico publicado en 2015

Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme

artículo científico publicado en 2014

Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei

artículo científico publicado en 2014

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

artículo científico publicado en 2005

Identification and Assay of Allosteric Regulators of S-Adenosylmethionine Decarboxylase ⬇️

artículo científico publicado el 1 de enero de 2011

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

artículo científico publicado en 2018

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

artículo científico publicado en 2016

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

artículo científico publicado en 2017

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

artículo científico publicado en 2009

Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

artículo científico publicado en 2016

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

artículo científico publicado en 2012

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

artículo científico publicado en 2020

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

artículo científico publicado en 2012

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

artículo científico publicado en 2011

Malaria

scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

artículo científico publicado en 2002

Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

artículo científico publicado en 2006

Modeling of the spatial structure of eukaryotic ornithine decarboxylases ⬇️

artículo científico publicado el 1 de julio de 1995

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase

artículo científico publicado en 2004

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

artículo científico publicado en 2021

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

artículo científico publicado en 2010

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis

artículo científico publicado en 2009

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

artículo científico publicado en 2010

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

artículo científico publicado en 2015

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

artículo científico publicado en 2003

Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases

artículo científico publicado en 2004

Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases

artículo científico publicado en 2007

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

artículo científico publicado en 2010

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

artículo científico publicado en 2021

Prized malaria drug target nailed ⬇️

artículo científico publicado el 1 de mayo de 2003

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme

artículo científico publicado en 2013

Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase

artículo científico publicado en 2002

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

artículo científico publicado en 2016

RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

artículo científico publicado en 2009

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes

artículo científico publicado en 2008

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

scientific article published on 15 December 2016

SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

artículo científico publicado en 2013

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

artículo científico publicado en 2017

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

artículo científico publicado en 2010

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

artículo científico publicado en 2017

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

artículo científico publicado en 2009

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

artículo científico publicado en 2011

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

artículo científico publicado en 2017

Targeted Nanodelivery of Drugs and Diagnostics

artículo científico publicado en 2010

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

artículo científico publicado en 2016

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions

artículo científico publicado en 2015

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

artículo científico publicado en 2008

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity †

artículo científico publicado en 2007

X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility

scientific article (publication date: 13 June 2003)

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

artículo científico publicado en 2011

Lista de obras de Margaret A. Phillips

A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei

A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

Anticancer properties of distinct antimalarial drug classes

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Chemical genetics of Plasmodium falciparum

Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis

Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine

Evolution of Substrate Specificity within a Diverse Family of / -Barrel-fold Basic Amino Acid Decarboxylases: X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE AND CARBOXYNORSPERMIDINE

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme

Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Identification and Assay of Allosteric Regulators of S-Adenosylmethionine Decarboxylase ⬇️

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Malaria

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

Modeling of the spatial structure of eukaryotic ornithine decarboxylases ⬇️

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases

Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Prized malaria drug target nailed ⬇️

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme

Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

Targeted Nanodelivery of Drugs and Diagnostics

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.