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27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease

scientific article published on 28 April 2020

A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

artículo científico publicado en 2021

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

scientific article published on 30 July 2019

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

scientific article published on 29 July 2019

Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses

scientific article published on 25 November 2020

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

artículo científico publicado en 2017

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

artículo científico publicado en 2021

Combinatorial expression of GPCR isoforms affects signalling and drug responses

artículo científico publicado en 2020

Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry

artículo científico publicado en 2020

Deep Profiling of the Aggregated Proteome in Alzheimer's Disease: From Pathology to Disease Mechanisms

scientific article published on 12 November 2018

Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

artículo científico publicado en 2019

Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis

artículo científico publicado en 2021

Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1

scientific article published on 04 February 2019

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

artículo científico publicado en 2018

Extensive Peptide Fractionation and y1 Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry.

artículo científico publicado en 2017

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

artículo científico publicado en 2021

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease

artículo científico publicado en 2020

Isotope Labeling-Assisted Evaluation of Hydrophilic and Hydrophobic Liquid Chromatograph-Mass Spectrometry for Metabolomics Profiling.

artículo científico publicado en 2018

JUMPt: Comprehensive Protein Turnover Modeling of In Vivo Pulse SILAC Data by Ordinary Differential Equations

artículo científico publicado en 2021

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

artículo científico publicado en 2022

Ligand-induced monoubiquitination of BIK1 regulates plant immunity

scientific article published on 22 April 2020

Multimodal Imaging of Amyloid Plaques: Fusion of the Single-Probe Mass Spectrometry Image and Fluorescence Microscopy Image ⬇️

artículo científico publicado en 2019

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

artículo científico publicado en 2021

Novel specialized cell state and spatial compartments within the germinal center

artículo científico publicado en 2020

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

article

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome.

artículo científico publicado en 2018

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

scientific article published on 10 April 2019

SMAP is a pipeline for sample matching in proteogenomics

artículo científico publicado en 2022

Spectral Library Search Improves Assignment of TMT Labeled MS/MS Spectra

scientific article published on 16 August 2018

Target-Decoy-Based False Discovery Rate Estimation for Large-Scale Metabolite Identification

scientific article published on 29 May 2018

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

artículo científico publicado en 2017

Lista de obras de

27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease

A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

Combinatorial expression of GPCR isoforms affects signalling and drug responses

Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry

Deep Profiling of the Aggregated Proteome in Alzheimer's Disease: From Pathology to Disease Mechanisms

Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis

Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

Extensive Peptide Fractionation and y1 Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry.

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease

Isotope Labeling-Assisted Evaluation of Hydrophilic and Hydrophobic Liquid Chromatograph-Mass Spectrometry for Metabolomics Profiling.

JUMPt: Comprehensive Protein Turnover Modeling of In Vivo Pulse SILAC Data by Ordinary Differential Equations

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

Ligand-induced monoubiquitination of BIK1 regulates plant immunity

Multimodal Imaging of Amyloid Plaques: Fusion of the Single-Probe Mass Spectrometry Image and Fluorescence Microscopy Image ⬇️

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

Novel specialized cell state and spatial compartments within the germinal center

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome.

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

SMAP is a pipeline for sample matching in proteogenomics

Spectral Library Search Improves Assignment of TMT Labeled MS/MS Spectra

Target-Decoy-Based False Discovery Rate Estimation for Large-Scale Metabolite Identification

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox