Lista de obras -

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

scientific article published on 26 September 2019

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

artículo científico publicado en 2003

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

artículo científico publicado en 2011

A metabolomic profile is associated with the risk of incident coronary heart disease

artículo científico publicado en 2014

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

artículo científico publicado en 2018

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

artículo científico publicado en 2016

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

artículo científico publicado en 2015

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs

scientific article published on 04 October 2014

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

scientific article published on 01 October 1999

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

artículo científico publicado en 2013

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

artículo científico publicado en 2002

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

scientific article published on 01 August 2019

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

artículo científico publicado en 2002

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes

artículo científico publicado en 2013

Combined association and linkage analysis applied to the APOE locus

artículo científico publicado en 2004

Commentary: The seven plagues of epigenetic epidemiology

artículo científico publicado en 2012

Common gene variants, mortality and extreme longevity in humans.

artículo científico publicado en 2000

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

artículo científico publicado en 2000

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

artículo científico publicado en 2024

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

artículo científico publicado en 2017

Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

artículo científico publicado en 2015

DNA Methylation Landscapes of Human Fetal Development

artículo científico publicado en 2015

DNA methylation aging clocks: challenges and recommendations

artículo científico publicado en 2019

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.

artículo científico publicado en 2017

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

artículo científico publicado en 2018

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

artículo científico publicado en 2009

DNA methylation differences at birth after conception through ART

scientific article published on 23 November 2020

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

artículo científico publicado en 2011

DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study

artículo científico publicado en 2013

DNA methylation profiles at birth and child ADHD symptoms

artículo científico publicado en 2013

DNA methylation signatures link prenatal famine exposure to growth and metabolism

artículo científico publicado en 2014

DNA methylation signatures of educational attainment

artículo científico publicado en 2018

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

artículo científico publicado en 2015

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

artículo científico publicado en 2015

Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study

artículo científico publicado en 2014

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

artículo científico publicado en 2013

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

artículo científico publicado en 2015

Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species

artículo científico publicado en 2022

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

artículo científico publicado en 2016

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

artículo científico publicado en 2009

Epigenetic signature of birth weight discordance in adult twins

artículo científico publicado en 2014

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

artículo científico publicado en 2012

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells

artículo científico publicado en 2014

Epigenome-Wide Association Study of Aggressive Behavior

artículo científico

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

artículo científico publicado en 2016

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

artículo científico publicado en 2003

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

artículo científico publicado en 2010

From promises to practical strategies in epigenetic epidemiology

artículo científico publicado en 2013

Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families

article

Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study

artículo científico publicado en 2006

Genetic and environmental influences interact with age and sex in shaping the human methylome.

artículo científico publicado en 2016

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

artículo científico publicado en 2017

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

artículo científico publicado en 2000

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs

scholarly article by Jenny van Dongen published in September 2018

Genome-wide analysis of constitutional DNA methylation in familial melanoma

artículo científico publicado en 2020

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

artículo científico publicado en 2014

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

artículo científico publicado en 2010

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

artículo científico publicado en 2011

Genome-wide identification of directed gene networks using large-scale population genomics data

scientific article published in Nature Communications

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

artículo científico publicado en 2020

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

artículo científico publicado en 2021

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

artículo científico publicado en 2011

Handling blood cell composition in epigenetic studies on ageing.

artículo científico publicado en 2017

Heritabilities of apolipoprotein and lipid levels in three countries

artículo científico publicado en 2002

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

scientific article published on 05 March 2007

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

artículo científico publicado en 2017

Human insulin/IGF-1 and familial longevity at middle age.

artículo científico publicado en 2009

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

artículo científico publicado en 2019

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

artículo científico publicado en 2011

Identical twins carry a persistent epigenetic signature of early genome programming

artículo científico publicado en 2021

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

artículo científico publicado en 2013

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

IgG glycosylation and DNA methylation are interconnected with smoking

artículo científico publicado en 2017

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

artículo científico publicado en 2004

Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming

artículo científico publicado en 2004

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

artículo científico publicado en 2021

LDL cholesterol still a problem in old age? A Mendelian randomization study

Lipid metabolism in long-lived families: the Leiden Longevity Study

artículo científico publicado en 2010

Lipoprotein particle profiles mark familial and sporadic human longevity

artículo científico publicado en 2006

Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

artículo científico publicado en 2012

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.

artículo científico publicado en 2015

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

artículo científico publicado en 2009

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

artículo científico publicado en 2012

Maternal Prenatal Nutrition and Health in Grandchildren and Subsequent Generations

article

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

artículo científico publicado en 2016

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions

artículo científico publicado en 2005

MethylAid: visual and interactive quality control of large Illumina 450k datasets.

artículo científico publicado en 2014

Molecular epidemiology, candidate genes versus genome-wide scans

artículo científico publicado en 2007

Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)

artículo científico publicado en 1999

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

artículo científico publicado en 2016

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study

artículo científico publicado en 2002

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

artículo científico publicado en 2013

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies

artículo científico publicado en 2015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

artículo científico publicado en 2009

Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene

artículo científico publicado en 2013

Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months.

artículo científico publicado en 2012

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child

artículo científico publicado en 2009

Persistent epigenetic differences associated with prenatal exposure to famine in humans

artículo científico publicado en 2008

Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

artículo científico publicado en 2012

Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study

artículo científico publicado en 2015

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

artículo científico publicado en 2017

RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting.

artículo científico publicado en 2019

Reduced insulin/IGF-1 signalling and human longevity.

artículo científico publicado en 2005

Relationship between genome and epigenome--challenges and requirements for future research

artículo científico publicado en 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

artículo científico publicado en 2020

Reply to 'Chinese famine and the diabetes mellitus epidemic'

scientific article published on 01 February 2020

Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM'

scientific article published on 01 February 2020

Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments

artículo científico publicado en 2018

Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families.

artículo científico publicado en 2005

Skewed X-inactivation is common in the general female population

artículo científico publicado en 2018

Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study

artículo científico publicado en 2012

Tea and coffee consumption in relation to DNA methylation in four European cohorts.

artículo científico publicado en 2017

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics

scientific article published on 01 June 2019

The epigenome: archive of the prenatal environment.

artículo científico publicado en 2009

The multifaceted interplay between lipids and epigenetics.

artículo científico publicado en 2016

The risk of mortality and the factor V Leiden mutation in a population-based cohort.

artículo científico publicado en 1998

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies

scientific article published on 24 April 2020

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

artículo científico publicado en 1999

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level

artículo científico publicado en 2004

TwinLIFE: The Twin Longitudinal Investigation of FEtal Discordance

scientific article published on 25 July 2019

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

artículo científico publicado en 2014

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

scholarly article published 19 October 2018

Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction

artículo científico publicado en 2012

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

artículo científico publicado en 2010

Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics

artículo científico publicado en 2018

omicsPrint: DETECTION OF DATA LINKAGE ERRORS IN MULTIPLE OMICS STUDIES.

artículo científico publicado en 2018

Lista de obras de

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

A metabolomic profile is associated with the risk of incident coronary heart disease

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Blood lipids influence DNA methylation in circulating cells

Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes

Combined association and linkage analysis applied to the APOE locus

Commentary: The seven plagues of epigenetic epidemiology

Common gene variants, mortality and extreme longevity in humans.

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

DNA Methylation Landscapes of Human Fetal Development

DNA methylation aging clocks: challenges and recommendations

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

DNA methylation differences at birth after conception through ART

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study

DNA methylation profiles at birth and child ADHD symptoms

DNA methylation signatures link prenatal famine exposure to growth and metabolism

DNA methylation signatures of educational attainment

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study

Disease variants alter transcription factor levels and methylation of their binding sites

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

Epigenetic signature of birth weight discordance in adult twins

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells

Epigenome-Wide Association Study of Aggressive Behavior

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

From promises to practical strategies in epigenetic epidemiology

Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families

Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study

Genetic and environmental influences interact with age and sex in shaping the human methylome.

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs

Genome-wide analysis of constitutional DNA methylation in familial melanoma

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

Genome-wide identification of directed gene networks using large-scale population genomics data

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

Genomics of human longevity.

Handling blood cell composition in epigenetic studies on ageing.

Heritabilities of apolipoprotein and lipid levels in three countries

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Human insulin/IGF-1 and familial longevity at middle age.

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

Identical twins carry a persistent epigenetic signature of early genome programming

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Identification of context-dependent expression quantitative trait loci in whole blood

IgG glycosylation and DNA methylation are interconnected with smoking