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Lista de obras de Christina S Leslie

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL ⬇️

artículo científico publicado en 2013

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells ⬇️

scholarly article

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

artículo científico publicado en 2015

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

artículo científico publicado en 2011

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

artículo científico publicado en 2015

A unified atlas of CD8 T cell dysfunctional states in cancer and infection

artículo científico publicado en 2021

ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

scientific article published on 13 January 2020

Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

scholarly article

Abstract 3384: Genome-wide epigenetic and transcriptional comparison of CD8 T cell functional states between mouse models of cancer and chronic viral infection

scholarly article

Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers

scholarly article

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

scholarly article

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

artículo científico publicado en 2020

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

artículo científico publicado en 2016

Affinity regression predicts the recognition code of nucleic acid–binding proteins

artículo científico publicado en 2015

An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron

artículo científico publicado en 2015

An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions

artículo científico publicado en 2012

An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.

artículo científico publicado en 2017

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

artículo científico publicado en 2014

Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility ⬇️

artículo científico publicado en 2025

Author Correction: FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

artículo científico publicado en 2020

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

artículo científico publicado en 2012

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

artículo científico publicado en 2022

BindSpace decodes transcription factor binding signals by large-scale sequence embedding

artículo científico publicado en 2019

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

artículo científico publicado en 2013

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.

artículo científico publicado en 2016

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

artículo científico publicado en 2014

Characterizing Transcriptional and Epigenetic Signatures Induced By FLT3-ITD Activation ⬇️

artículo científico publicado en 2014

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility ⬇️

artículo científico publicado en 2024

Chromatin states define tumour-specific T cell dysfunction and reprogramming.

artículo científico publicado en 2017

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

artículo científico publicado en 2019

Combining classifiers for improved classification of proteins from sequence or structure

artículo científico publicado en 2008

Combining integrated genomics and functional genomics to dissect the biology of a cancer‐associated, aberrant transcription factor, the ASPSCR1–TFE3 fusion oncoprotein ⬇️

artículo científico publicado el 5 de marzo de 2013

Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans

artículo científico publicado en 2010

Computational searches for splicing signals.

artículo científico publicado en 2005

Cooperative control of tumor suppressor genes by a network of oncogenic microRNAs ⬇️

artículo científico publicado el 1 de septiembre de 2011

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

artículo científico publicado en 2015

Determining frequent patterns of copy number alterations in cancer

artículo científico publicado en 2010

Dichotomous splicing signals in exon flanks

artículo científico publicado en 2005

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate. ⬇️

artículo científico publicado en 2012

Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation

artículo científico publicado en 2015

Epigenetic control of innate and adaptive immune memory

artículo científico publicado en 2018

Ets transcription factor GABP controls T cell homeostasis and immunity

artículo científico publicado en 2017

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

scientific article published on 26 June 2019

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

scientific article published on 01 July 2019

FXR mediates T cell-intrinsic responses to reduced feeding during infection

artículo científico publicado en 2020

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

artículo científico publicado en 2010

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

artículo científico publicado en 2010

Global 3' UTR Sequencing in Multiple Myeloma (MM) ⬇️

artículo científico publicado en 2015

Global profiling of stimulus-induced polyadenylation in cells using a poly(A) trap

artículo científico publicado en 2013

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

scientific article published on 01 May 2021

GuideScan software for improved single and paired CRISPR guide RNA design

artículo científico publicado en 2017

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

artículo científico publicado en 2010

High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down

scientific article published on 29 May 2020

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

scientific article published on 24 April 2020

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

artículo científico publicado en 2018

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells ⬇️

scholarly article

IKZF2, a Novel Target of MSI2 RNA-Binding Protein Plays an Oncogenic Role in Myeloid Leukemia ⬇️

scholarly article

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

artículo científico publicado en 2017

Ibrutinib resistance in chronic lymphocytic leukemia

artículo científico publicado en 2014

Identifying remote protein homologs by network propagation

artículo científico publicado en 2005

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

artículo científico publicado en 2015

Induction of specific microRNAs inhibits cutaneous wound healing

scientific journal article

Inferring transcriptional and microRNA‐mediated regulatory programs in glioblastoma ⬇️

artículo científico publicado el 1 de enero de 2012

Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer

artículo científico publicado en 2016

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

artículo científico publicado en 2021

Learning to Predict miRNA-mRNA Interactions from AGO CLIP Sequencing and CLASH Data

artículo científico publicado en 2016

Linking signaling pathways to transcriptional programs in breast cancer.

artículo científico publicado en 2014

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

artículo científico publicado en 2016

Memory of Inflammation in Regulatory T Cells

artículo científico publicado en 2016

MiR-28 Silencing In Germinal Center-Derived Lymphomas ⬇️

artículo científico publicado en 2010

MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.

artículo científico publicado en 2014

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging ⬇️

artículo científico publicado en 2014

Mismatch string kernels for discriminative protein classification

artículo científico publicado en 2004

Motif-based protein ranking by network propagation

artículo científico publicado en 2005

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12

scientific article published on 01 July 2019

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program ⬇️

artículo científico publicado en 2014

Multitask learning improves prediction of cancer drug sensitivity

artículo científico publicado en 2016

NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A

artículo científico publicado en 2008

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

scientific article published on 23 April 2019

Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection

artículo científico publicado en 2018

PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

article

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

artículo científico publicado en 2017

Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs.

artículo científico publicado en 2017

Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility

artículo científico publicado en 2021

Prediction of potent shRNAs with a sequential classification algorithm

artículo científico publicado en 2017

Profile-based string kernels for remote homology detection and motif extraction

artículo científico publicado en 2005

Profile-based string kernels for remote homology detection and motif extraction

artículo científico publicado en 2004

Programme of self-reactive innate-like T cell-mediated cancer immunity

artículo científico publicado en 2022

Protein backbone angle prediction with machine learning approaches.

artículo científico publicado en 2004

Protein ranking by semi-supervised network propagation

artículo científico publicado en 2006

Protein ranking: from local to global structure in the protein similarity network

artículo científico publicado en 2004

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program ⬇️

scholarly article

Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure

artículo científico publicado en 2003

SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes

artículo científico publicado en 2022

SeqGL Identifies Context-Dependent Binding Signals in Genome-Wide Regulatory Element Maps

artículo científico publicado en 2015

Sequence information for the splicing of human pre-mRNA identified by support vector machine classification

artículo científico publicado en 2003

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

artículo científico publicado en 2021

Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

artículo científico publicado en 2022

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

artículo científico publicado en 2019

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia

artículo científico publicado en 2017

Target mRNA abundance dilutes microRNA and siRNA activity

artículo científico publicado en 2010

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

artículo científico publicado en 2017

The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries

artículo científico publicado en 2020

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

scientific article published on 17 September 2018

Therapeutic Transgene Expression From Genomic Safe Harbors In Patient-Specific Induced Pluripotent Stem Cells ⬇️

artículo científico publicado en 2010

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

scientific article published on 14 January 2019

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

scientific article published on 24 October 2019

Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting

artículo científico publicado en 2012

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

artículo científico publicado en 2009

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

artículo científico publicado en 2013

Widespread intronic polyadenylation diversifies immune cell transcriptomes.

artículo científico publicado en 2018

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia.

artículo científico publicado en 2018

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