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A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.

artículo científico publicado en 2015

A specific amyloid-beta protein assembly in the brain impairs memory

scientific journal article published in 2006. 14 July 2022 Editor’s Note: readers are advised to use caution when using results reported therein.

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

artículo científico publicado el 14 de julio de 2009

Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines

artículo científico publicado en 2010

Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain

artículo científico publicado el 20 de abril de 2011

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

artículo científico publicado en 2014

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

artículo científico publicado en 2008

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes.

artículo científico publicado en 2015

Azure C Targets and Modulates Toxic Tau Oligomers.

artículo científico publicado en 2018

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

artículo científico publicado en 2005

Characterization of tau oligomeric seeds in progressive supranuclear palsy

artículo científico publicado en 2014

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

artículo científico publicado en 2005

Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies

artículo científico publicado el 21 de abril de 2012

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

artículo científico publicado en 2006

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity.

artículo científico publicado en 2012

Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy

artículo científico publicado en 2007

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

artículo científico publicado en 2008

Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?

artículo científico publicado en 2013

Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules

artículo científico publicado en 2020

Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

artículo científico publicado en 2005

Preparation and Characterization of Neurotoxic Tau Oligomers

artículo científico publicado el 8 de noviembre de 2010

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

artículo científico publicado en 2020

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy

artículo científico publicado en 2005

Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

artículo científico publicado en 2005

Soluble and mature amyloid fibrils in drusen deposits

artículo científico publicado en 2009

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

artículo científico publicado en 2019

The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes

artículo científico publicado en 2014

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins.

artículo científico

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

artículo científico publicado en 2007