Lista de obras -

1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs

artículo científico publicado en 2010

2-Arylidenedihydroindole-3-ones: design, synthesis, and biological activity on bladder carcinoma cell lines.

artículo científico publicado en 2006

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

artículo científico publicado en 2016

3-Aryl-4-methyl-2-quinolones targeting multiresistant Staphylococcus aureus bacteria.

artículo científico publicado en 2013

6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein

artículo científico publicado en 2012

A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.

artículo científico publicado en 2015

A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis ⬇️

artículo científico publicado el 30 de enero de 2012

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

artículo científico publicado en 2009

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol

artículo científico publicado en 2015

A template model for studying anticancer drug efflux transporter inhibitors in vitro

artículo científico publicado en 2012

ABCG2: recent discovery of potent and highly selective inhibitors

artículo científico

AG11, a novel dichloroflavanone derivative with anti-mitotic activity towards human bladder cancer cells

artículo científico publicado en 2013

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

artículo científico publicado en 2007

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

artículo científico publicado en 2005

Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones.

artículo científico publicado en 2004

Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.

artículo científico publicado en 2008

Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

artículo científico publicado en 2016

Arylthiosemicarbazones as antileishmanial agents

artículo científico publicado en 2016

Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens

artículo científico publicado en 2019

B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

artículo científico publicado en 2014

Biomimetic synthesis of Tramadol

artículo científico publicado en 2015

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

artículo científico publicado en 2009

Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects

artículo científico publicado en 2013

Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors.

artículo científico publicado en 2012

Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs?

artículo científico publicado en 2009

Chemical composition of the pods of Albizia polyphylla

artículo científico publicado en 2015

Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2

artículo científico publicado en 2020

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

artículo científico publicado en 2014

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

artículo científico publicado en 2017

Dicarboxylate-Oside Detergents for Extraction, Overstabilization and Crystallization of Membrane Proteins.

artículo científico publicado en 2018

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells

artículo científico publicado en 2011

Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

artículo científico publicado en 2011

Disruption of Fibers from the Tau Model AcPHF6 by Naturally Occurring Aurones and Synthetic Analogues

artículo científico publicado en 2016

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

artículo científico publicado en 2017

Flavonoids as RTK inhibitors and potential anticancer agents

artículo científico publicado en 2008

General Articles Aurones: A Subclass of Flavones with Promising Biological Potential ⬇️

artículo científico publicado el 1 de diciembre de 2003

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

artículo científico publicado en 2015

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

artículo científico publicado en 2013

Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.

artículo científico publicado en 2011

Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma.

artículo científico publicado en 2009

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity

artículo científico publicado en 2012

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

artículo científico publicado en 2014

MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.

artículo científico publicado en 2016

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans

scientific article published on 25 July 2018

Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

artículo científico publicado en 2003

Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?

artículo científico publicado en 2006

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

scientific article published on 06 May 2020

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree

artículo científico publicado en 2016

New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase

artículo científico publicado en 2016

New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2.

artículo científico publicado en 2016

Occurrence of the synthetic analgesic tramadol in an African medicinal plant

artículo científico publicado en 2013

Occurrences, biosynthesis and properties of aurones as high-end evolutionary products.

artículo científico

Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2

scientific article published on 10 October 2019

Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition

artículo científico publicado en 2018

Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets

artículo científico publicado en 2020

Piperazinobenzopyranones and phenalkylaminobenzopyranones: potent inhibitors of breast cancer resistance protein (ABCG2).

artículo científico publicado en 2005

Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models

artículo científico publicado en 2018

Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.

artículo científico publicado en 2013

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

artículo científico publicado en 2002

Structural requirement of arylindolylpropenones as anti-bladder carcinoma cells agents ⬇️

artículo científico publicado el 16 de agosto de 2011

Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research

artículo científico publicado en 2012

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

artículo científico publicado en 2013

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein

artículo científico publicado en 2012

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

artículo científico publicado en 2014

The effect of flavonoid derivatives on doxorubicin transport and metabolism.

artículo científico publicado en 2007

Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review ⬇️

artículo científico publicado en 2017

Two in one: bifonctional derivatives of trolox acting as antimalarial and antioxidant agents

artículo científico publicado en 2020

Lista de obras de

1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs

2-Arylidenedihydroindole-3-ones: design, synthesis, and biological activity on bladder carcinoma cell lines.

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

3-Aryl-4-methyl-2-quinolones targeting multiresistant Staphylococcus aureus bacteria.

6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein

A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.

A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis ⬇️

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol

A template model for studying anticancer drug efflux transporter inhibitors in vitro

ABCG2: recent discovery of potent and highly selective inhibitors

AG11, a novel dichloroflavanone derivative with anti-mitotic activity towards human bladder cancer cells

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones.

Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.

Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Arylthiosemicarbazones as antileishmanial agents

Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens

B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Biomimetic synthesis of Tramadol

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects

Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors.

Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs?

Chemical composition of the pods of Albizia polyphylla

Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

Dicarboxylate-Oside Detergents for Extraction, Overstabilization and Crystallization of Membrane Proteins.

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells

Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Disruption of Fibers from the Tau Model AcPHF6 by Naturally Occurring Aurones and Synthetic Analogues

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

Flavonoids as RTK inhibitors and potential anticancer agents

General Articles Aurones: A Subclass of Flavones with Promising Biological Potential ⬇️

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.

Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma.

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans

Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues

Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport?

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree

New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase

New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2.

Occurrence of the synthetic analgesic tramadol in an African medicinal plant

Occurrences, biosynthesis and properties of aurones as high-end evolutionary products.

Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2

Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition

Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets

Piperazinobenzopyranones and phenalkylaminobenzopyranones: potent inhibitors of breast cancer resistance protein (ABCG2).

Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models

Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

Structural requirement of arylindolylpropenones as anti-bladder carcinoma cells agents ⬇️

Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

The effect of flavonoid derivatives on doxorubicin transport and metabolism.

Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review ⬇️

Two in one: bifonctional derivatives of trolox acting as antimalarial and antioxidant agents