Lista de obras -

A Method for Intratumoral Continuous Infusion of Antisense Oligodeoxynucleotides ⬇️

artículo científico publicado el 1 de marzo de 1998

A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy.

artículo científico publicado en 2009

A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma.

artículo científico publicado en 2009

A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site

artículo científico publicado en 2010

A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma.

artículo científico publicado en 2006

Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion.

artículo científico publicado en 2010

Bim-targeted cancer therapy: a link between drug action and underlying molecular changes.

artículo científico publicado en 2009

Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

artículo científico publicado en 2008

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

artículo científico publicado en 2020

Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy.

scientific article published on 25 September 2009

Cancer, chitosan nanoparticles and catalytic nucleic acids.

artículo científico publicado en 2009

Carrier-mediated delivery of peptidic drugs for cancer therapy.

artículo científico publicado en 2006

Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular ⬇️

artículo científico publicado el 28 de mayo de 2012

Cellular assays and applied technologies for characterisation of orally administered protein nanoparticles: a systematic review

artículo científico publicado en 2020

Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma.

artículo científico publicado en 2007

Chitosan-mediated orally delivered nucleic acids: a gutful of gene therapy.

artículo científico publicado en 2008

Commonly used mouse models of osteosarcoma.

artículo científico publicado en 2006

Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles

scientific article published on 20 April 2020

DNAzyme delivery systems: getting past first base

artículo científico publicado en 2009

DNAzyme technology and cancer therapy: cleave and let die.

artículo científico publicado en 2008

Delivery of therapeutics for deep-seated ocular conditions - status quo.

artículo científico publicado en 2018

Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization

artículo científico publicado en 2020

Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours.

artículo científico publicado en 2010

Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model.

artículo científico publicado en 2008

Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma

scientific article published on 01 January 2005

Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use.

artículo científico publicado en 2018

Dz13 induces a cytotoxic stress response with upregulation of E2F1 in tumor cells metastasizing to or from bone.

artículo científico publicado en 2010

Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation.

artículo científico publicado en 2010

Dz13: c‐Jun Downregulation and Tumour Cell Death ⬇️

artículo científico publicado el 31 de octubre de 2011

Enhanced Anticancer Therapy Mediated by Specialized Liposomes ⬇️

artículo científico publicado el 1 de octubre de 1997

Fabrication techniques for the preparation of orally administered insulin nanoparticles

artículo científico publicado en 2020

GFP expression alters osteosarcoma cell biology.

artículo científico publicado en 2007

Gene therapy for osteosarcoma: steps towards clinical studies.

scientific article published on April 2008

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing.

artículo científico publicado en 2006

In vitro and in vivo biological activity of PEDF against a range of tumors.

artículo científico publicado en 2009

Induction of Caspase-2 Activation by a DNA Enzyme Evokes Tumor Cell Apoptosis ⬇️

artículo científico publicado el 11 de noviembre de 2011

Methods for co-culturing tumour and endothelial cells: systems and their applications ⬇️

artículo científico publicado el 19 de septiembre de 2011

Microarray: an instrument for cancer surgeons of the future?

artículo científico publicado en 2010

Netrin-1 in the developing enteric nervous system and colorectal cancer ⬇️

artículo científico publicado el 21 de agosto de 2012

New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasis

artículo científico publicado en 2010

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway.

artículo científico publicado en 2008

Oral insulin delivery: existing barriers and current counter-strategies

artículo científico publicado en 2017

Osteosarcoma treatment: state of the art.

artículo científico publicado en 2009

PEDF as an emerging therapeutic candidate for osteosarcoma.

artículo científico publicado en 2008

PEDF regulates osteoclasts via osteoprotegerin and RANKL

scientific article published on 27 November 2009

PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma.

artículo científico publicado en 2007

PEDF: a potential molecular therapeutic target with multiple anti-cancer activities.

artículo científico publicado en 2006

Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective ⬇️

artículo científico publicado el 5 de enero de 2011

Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis.

artículo científico publicado en 2010

Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy

artículo científico publicado en 2018

RECK in osteosarcoma: a novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model

scientific article published on 01 February 2011

Review: doxorubicin delivery systems based on chitosan for cancer therapy.

scientific article published on February 2009

Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability.

artículo científico publicado en 2006

Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model ⬇️

artículo científico publicado el 6 de octubre de 2011

Targeting of small molecule anticancer drugs to the tumour and its vasculature using cationic liposomes: lessons from gene therapy.

artículo científico publicado en 2006

The Emerging Role of PEDF in Stem Cell Biology ⬇️

artículo científico publicado el 17 de mayo de 2012

The Reciprocal Interaction: Chemotherapy and Tumor Microenvironment ⬇️

artículo científico publicado el 1 de junio de 2011

The molecular pathogenesis of osteosarcoma: a review

artículo científico publicado en 2011

The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation

artículo científico publicado en 2017

The role of pigment epithelium-derived factor in protecting against cellular stress

scientific article published on 06 December 2019

The use of chitosan formulations in cancer therapy

scientific article published on 01 June 2008

Therapeutic targeting of osteoclast function and pathways.

artículo científico publicado en 2011

Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment.

artículo científico publicado en 2018

Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy

artículo científico publicado en 2017

Weak bones in diabetes mellitus - an update on pharmaceutical treatment options

artículo científico publicado en 2017

c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

artículo científico publicado en 2008

c-Jun knockdown sensitizes osteosarcoma to doxorubicin.

artículo científico publicado en 2008

uPAR mediates anticancer activity of PEDF.

artículo científico publicado en 2008

Lista de obras de

A Method for Intratumoral Continuous Infusion of Antisense Oligodeoxynucleotides ⬇️

A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy.

A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma.

A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site

A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma.

Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion.

Bim-targeted cancer therapy: a link between drug action and underlying molecular changes.

Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy.

Cancer, chitosan nanoparticles and catalytic nucleic acids.

Carrier-mediated delivery of peptidic drugs for cancer therapy.

Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular ⬇️

Cellular assays and applied technologies for characterisation of orally administered protein nanoparticles: a systematic review

Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma.

Chitosan-mediated orally delivered nucleic acids: a gutful of gene therapy.

Commonly used mouse models of osteosarcoma.

Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles

DNAzyme delivery systems: getting past first base

DNAzyme technology and cancer therapy: cleave and let die.

Delivery of therapeutics for deep-seated ocular conditions - status quo.

Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization

Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours.

Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model.

Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma

Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use.

Dz13 induces a cytotoxic stress response with upregulation of E2F1 in tumor cells metastasizing to or from bone.

Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation.

Dz13: c‐Jun Downregulation and Tumour Cell Death ⬇️

Enhanced Anticancer Therapy Mediated by Specialized Liposomes ⬇️

Fabrication techniques for the preparation of orally administered insulin nanoparticles

GFP expression alters osteosarcoma cell biology.

Gene therapy for osteosarcoma: steps towards clinical studies.

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing.

In vitro and in vivo biological activity of PEDF against a range of tumors.

Induction of Caspase-2 Activation by a DNA Enzyme Evokes Tumor Cell Apoptosis ⬇️

Methods for co-culturing tumour and endothelial cells: systems and their applications ⬇️

Microarray: an instrument for cancer surgeons of the future?

Netrin-1 in the developing enteric nervous system and colorectal cancer ⬇️

New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasis

Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway.

Oral insulin delivery: existing barriers and current counter-strategies

Osteosarcoma treatment: state of the art.

PEDF as an emerging therapeutic candidate for osteosarcoma.

PEDF regulates osteoclasts via osteoprotegerin and RANKL

PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma.

PEDF: a potential molecular therapeutic target with multiple anti-cancer activities.

Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective ⬇️

Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis.

Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy

RECK in osteosarcoma: a novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model

Review: doxorubicin delivery systems based on chitosan for cancer therapy.

Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability.

Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model ⬇️

Targeting of small molecule anticancer drugs to the tumour and its vasculature using cationic liposomes: lessons from gene therapy.

The Emerging Role of PEDF in Stem Cell Biology ⬇️

The Reciprocal Interaction: Chemotherapy and Tumor Microenvironment ⬇️

The molecular pathogenesis of osteosarcoma: a review

The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation

The role of pigment epithelium-derived factor in protecting against cellular stress

The use of chitosan formulations in cancer therapy

Therapeutic targeting of osteoclast function and pathways.

Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment.

Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy

Weak bones in diabetes mellitus - an update on pharmaceutical treatment options

c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

c-Jun knockdown sensitizes osteosarcoma to doxorubicin.

uPAR mediates anticancer activity of PEDF.