Lista de obras -

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

artículo científico publicado en 2016

ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

artículo científico publicado en 2016

ABC transporters in cancer: more than just drug efflux pumps.

artículo científico publicado en 2010

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

artículo científico publicado en 2011

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

scientific article published on 10 January 2020

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

artículo científico publicado en 2007

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

artículo científico publicado en 2008

CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth

artículo científico publicado en 2019

CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma

artículo científico publicado en 2020

Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma

scientific article published on 22 February 2020

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

artículo científico publicado en 2016

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

artículo científico publicado en 2014

Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen

artículo científico publicado en 2014

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

artículo científico publicado en 2019

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

scientific article published on 11 July 2019

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

artículo científico publicado en 2016

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

artículo científico publicado en 2015

Mouse models of high-risk neuroblastoma

artículo científico publicado en 2020

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

artículo científico publicado en 2011

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

artículo científico publicado en 2021

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

artículo científico publicado en 2020

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

artículo científico publicado en 2017

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

artículo científico publicado en 2020

Targeting Functional Activity of AKT Has Efficacy against Aggressive Neuroblastoma

scientific article published on 23 January 2020

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

artículo científico publicado en 2024

The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression

artículo científico publicado en 2016

Too many targets, not enough patients: rethinking neuroblastoma clinical trials.

artículo científico publicado en 2018

Lista de obras de

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

ABC transporters in cancer: more than just drug efflux pumps.

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth

CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma

Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

Mouse models of high-risk neuroblastoma

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

Targeting Functional Activity of AKT Has Efficacy against Aggressive Neuroblastoma

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression

Too many targets, not enough patients: rethinking neuroblastoma clinical trials.