Lista de obras -

2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).

artículo científico publicado en 2017

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

artículo científico publicado en 2008

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.

artículo científico publicado en 2016

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia

artículo científico publicado en 2012

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.

artículo científico publicado en 2010

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha. ⬇️

artículo científico publicado en 2010

Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins

artículo científico publicado en 2007

Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?

artículo científico publicado en 2005

Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status

artículo científico publicado en 2007

Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

artículo científico publicado en 2004

Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

artículo científico publicado en 2012

Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis

artículo científico publicado en 2006

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review

artículo científico publicado en 2009

Cytochrome c and c1 heme lyases are essential in Plasmodium berghei

article

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.

artículo científico publicado en 2015

DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium ⬇️

artículo científico publicado el 2 de febrero de 2011

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates

artículo científico publicado en 2016

Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum

artículo científico publicado en 2002

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.

artículo científico publicado en 2003

Enhancement of DNA hybridization under acoustic streaming with three-piezoelectric-transducer system ⬇️

artículo científico publicado el 10 de noviembre de 2011

Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.

artículo científico publicado en 2015

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

artículo científico publicado en 2011

Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.

artículo científico publicado en 2002

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

artículo científico publicado en 2006

Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria

artículo científico publicado en 2009

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.

artículo científico publicado en 2011

Folate metabolism as a source of molecular targets for antimalarials.

artículo científico publicado en 2006

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

artículo científico publicado en 2013

Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine ⬇️

artículo científico publicado el 18 de agosto de 2011

Hematological parameters and red blood cell morphological abnormality of Glucose-6-Phosphate dehydrogenase deficiency co-inherited with thalassemia

artículo científico publicado en 2017

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

artículo científico publicado en 2016

Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.

artículo científico publicado en 2007

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme

artículo científico publicado en 2013

Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates

artículo científico publicado en 2016

Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

artículo científico publicado en 2004

Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum

artículo científico publicado en 2015

Insights into antifolate resistance from malarial DHFR-TS structures

artículo científico publicado en 2003

Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases

artículo científico publicado en 2009

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

artículo científico publicado en 2012

Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins

artículo científico publicado en 2014

Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.

artículo científico publicado en 2014

Monitoring drug resistance in Plasmodium falciparum clinical isolates collected from Northern Thailand

artículo científico publicado en 2014

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.

artículo científico publicado en 2002

Origin of robustness in generating drug-resistant malaria parasites

artículo científico publicado en 2014

Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

article

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa

artículo científico publicado el 1 de mayo de 2012

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

artículo científico publicado en 2015

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

artículo científico publicado en 2010

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model ⬇️

artículo científico publicado en 2011

Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment.

artículo científico publicado en 2011

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

artículo científico publicado en 2009

Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

artículo científico publicado en 2005

Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.

artículo científico publicado en 2003

Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum

artículo científico publicado en 2004

The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

artículo científico publicado en 2007

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

artículo científico publicado en 2011

Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance ⬇️

artículo científico publicado el 16 de junio de 2011

Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.

artículo científico publicado en 2015

Validation of deoxyhypusine synthase as an antimalarial target

artículo científico publicado en 2019

Lista de obras de

2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha. ⬇️

Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins

Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?

Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status

Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review

Cytochrome c and c1 heme lyases are essential in Plasmodium berghei

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.

DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium ⬇️

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates

Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity.

Enhancement of DNA hybridization under acoustic streaming with three-piezoelectric-transducer system ⬇️

Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.

Folate metabolism as a source of molecular targets for antimalarials.

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine ⬇️

Hematological parameters and red blood cell morphological abnormality of Glucose-6-Phosphate dehydrogenase deficiency co-inherited with thalassemia

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme

Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates

Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum

Insights into antifolate resistance from malarial DHFR-TS structures

Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins

Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.

Monitoring drug resistance in Plasmodium falciparum clinical isolates collected from Northern Thailand

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.

Origin of robustness in generating drug-resistant malaria parasites

Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model ⬇️

Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment.

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.

Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum

The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance ⬇️

Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.

Validation of deoxyhypusine synthase as an antimalarial target