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Lista de obras de Maurizio Botta

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

artículo científico publicado en 2012

(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity

artículo científico publicado en 2020

1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation.

artículo científico publicado en 2009

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

artículo científico publicado en 2005

1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

artículo científico publicado en 2008

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies

artículo científico publicado en 2008

2-Aminothiazolones as anti-HIV agents that act as gp120-CD4 inhibitors.

artículo científico publicado en 2014

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

artículo científico publicado en 2010

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

artículo científico publicado en 2016

3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors

artículo científico publicado en 2009

3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.

artículo científico publicado en 2004

3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin

artículo científico publicado en 2003

3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones

artículo científico publicado en 2003

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling

artículo científico publicado en 2016

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein

scientific article published on 19 March 2020

A Combination of Molecular Dynamics and Docking Calculations to Explore the Binding Mode of ADS-J1, a Polyanionic Compound Endowed with Anti-HIV-1 Activity

article

A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones

A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1

artículo científico publicado en 2019

A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-]Pyrimidine Dual Src/P-Glycoprotein Inhibitor

scientific article published on 19 June 2019

A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies

artículo científico publicado en 1994

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies

artículo científico publicado en 2016

A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia

artículo científico publicado en 2016

A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues

artículo científico publicado en 2007

A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia

artículo científico publicado en 2020

A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors

scientific article published on 01 June 2006

A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.

artículo científico publicado en 2013

A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation

artículo científico publicado en 2012

A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions

artículo científico publicado en 2009

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase

artículo científico publicado en 2011

A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward alpha1 adrenoceptors

artículo científico publicado en 2006

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

artículo científico publicado en 2008

A new and efficient synthesis of substituted 6-[(2'-dialkylamino)ethyl] pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity.

artículo científico publicado en 2002

A new linker for anchoring/masking primary amines on solid support

artículo científico publicado en 2005

A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib

artículo científico publicado en 2010

A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs)

A unique domain for a unique target: selective inhibitors of host cell DDX3X to fight emerging viruses

artículo científico publicado en 2020

A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors

artículo científico publicado en 2011

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

article

Alkyne-enol ether cross-metathesis in the presence of CuSO(4): direct formation of 3-substituted crotonaldehydes in aqueous medium

artículo científico publicado en 2009

Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders ⬇️

artículo científico publicado el 1 de enero de 2013

Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives

artículo científico publicado en 2002

Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety

artículo científico publicado en 2003

An Update On Dual Src/Abl Inhibitors ⬇️

artículo científico publicado el 1 de abril de 2012

An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines

Analysis of guazatine mixture by LC and LC–MS and antimycotic activity determination of principal components

article

Anti-inflammatory activity of a new class of nitric oxide synthase inhibitors that release nitric oxide

artículo científico publicado en 2008

Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies

artículo científico publicado en 2002

Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats

artículo científico publicado en 2020

Antimycobacterial Agents. Novel Diarylpyrrole Derivatives of BM212 Endowed with High Activity toward Mycobacterium tuberculosis and Low Cytotoxicity

artículo científico publicado en 2006

Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line

artículo científico publicado en 2004

Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells

artículo científico publicado en 2010

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

artículo científico publicado en 2008

Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition

artículo científico publicado en 2012

Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors

AuNP Pyrazolo[3,4-d]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma

scientific article published on 05 March 2020

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi.

artículo científico publicado en 2016

Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound

artículo científico publicado en 2016

Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies

artículo científico

C6-unsubstituted pyrazolo[3,4-d]pyrimidines are dual Src/Abl inhibitors effective against imatinib mesylate resistant chronic myeloid leukemia cell lines

artículo científico publicado en 2009

CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction

artículo científico publicado en 2014

Caracasanamide, a novel hypotensive agent from Verbesina caracasana

artículo científico publicado en 2002

Caracasandiamide, a truxinic hypotensive agent from Verbesina caracasana

artículo científico publicado en 2003

Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02

scientific article published on 01 December 2019

Chiral recognition by resorcin[4]arene receptors: intrinsic kinetics and dynamics

artículo científico publicado en 2004

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

artículo científico publicado en 2015

Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle.

artículo científico publicado en 2005

Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma

artículo científico publicado en 2015

Computational Studies Identifying Entry Inhibitor Scaffolds Targeting the Phe 43 Cavity of HIV‐1 gp120 ⬇️

artículo científico publicado el 12 de febrero de 2013

Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine

artículo científico publicado en 2004

Computational studies of the interaction between the HIV‐1 integrase tetramer and the cofactor LEDGF/p75: Insights from molecular dynamics simulations and the Informational spectrum method ⬇️

artículo científico publicado el 27 de septiembre de 2010

Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case

artículo científico publicado en 2011

Construction and validation of a RET TK catalytic domain by homology modeling

artículo científico publicado en 2007

Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action

artículo científico publicado en 2010

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

artículo científico publicado en 2009

Cyclic Dipeptides. 3.1 Synthesis of Methyl (R)-6-[(tert-Butoxycarbonyl)amino]-4,5,6,7- tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate and Its Hexahydro Analogues: Elaboration of a Novel Dual ACE/NEP Inhibitor ⬇️

artículo científico publicado el 30 de abril de 1999

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

artículo científico publicado en 2007

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

scientific article published on 21 February 2019

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

artículo científico publicado en 2020

Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.

artículo científico publicado en 2017

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors

artículo científico publicado en 2010

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

artículo científico publicado en 2018

Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion

artículo científico publicado en 2004

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.

artículo científico publicado en 2013

Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.

artículo científico publicado en 2011

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

artículo científico publicado en 2009

Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach

artículo científico publicado en 2011

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family

artículo científico publicado en 2016

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors

artículo científico publicado en 2012

Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae).

artículo científico publicado en 2017

Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor.

artículo científico publicado en 2017

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

artículo científico publicado en 2007

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

artículo científico publicado en 2007

Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus

artículo científico publicado en 2013

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

artículo científico publicado en 2014

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products

artículo científico publicado en 2013

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate

article

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

artículo científico publicado en 2009

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

artículo científico publicado en 2016

Discovery of new therapeutic targets by the informational spectrum method

artículo científico publicado en 2008

Discovery of small molecule HIV-1 integrase dimerization inhibitors

artículo científico publicado en 2012

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

artículo científico publicado en 2020

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

artículo científico publicado en 2014

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.

artículo científico publicado en 2012

Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors

artículo científico publicado en 2008

Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †

artículo científico publicado en 2020

Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms

artículo científico publicado en 2010

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment

scientific article published on 20 September 2018

Enantioselective guest exchange in a chiral resorcin[4]arene cavity

artículo científico publicado en 2002

Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones

artículo científico publicado en 2010

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors

artículo científico publicado en 2009

Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

scientific article published on 09 April 2020

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

artículo científico publicado en 2014

Flattened cone 2,8,14,20-tetrakis(L-valinamido)[4]resorcinarene: an enantioselective allosteric receptor in the gas phase

artículo científico publicado en 2006

Flavin-containing polyamine oxidase is a hydrogen peroxide source in the oxidative response to the protein phosphatase inhibitor cantharidin in Zea mays L

artículo científico publicado en 2006

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

artículo científico publicado en 2012

From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.

artículo científico publicado en 2010

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

artículo científico publicado en 2014

Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors

scientific article published on 01 October 2006

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

artículo científico publicado en 2014

Guanylated Diamines, Triamines, and Polyamines: Chemistry and Biological Properties ⬇️

artículo científico publicado el 9 de junio de 2011

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate

artículo científico publicado en 2010

Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.

artículo científico publicado en 2016

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction.

artículo científico publicado en 2013

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

artículo científico publicado en 2015

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

artículo científico publicado en 2015

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

artículo científico publicado en 2016

Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors

artículo científico publicado en 2015

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents

artículo científico publicado en 2013

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

artículo científico publicado en 2020

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines

scientific article published on 18 July 2019

Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice

artículo científico publicado en 2007

Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin

artículo científico publicado en 2010

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling ⬇️

artículo científico publicado el 4 de noviembre de 2011

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein

artículo científico publicado en 2017

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells

artículo científico publicado en 2011

Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein–protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis ⬇️

artículo científico publicado el 8 de agosto de 2010

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.

artículo científico publicado en 2017

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

artículo científico publicado en 2013

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

artículo científico

In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains

scientific article published on 20 December 2019

Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors

artículo científico publicado en 2009

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

artículo científico publicado en 2014

Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells

artículo científico publicado en 2007

Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules

artículo científico publicado en 2016

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography

artículo científico publicado en 2013

Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria.

artículo científico publicado en 2016

Inhibition of polyamine and spermine oxidases by polyamine analogues.

artículo científico publicado en 2006

Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase

Insight into the allosteric inhibition of Abl kinase

artículo científico publicado en 2014

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments

artículo científico

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

artículo científico publicado en 2008

Involvement of polyamine oxidase in wound healing.

artículo científico publicado en 2007

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

artículo científico publicado en 2015

LC/ESI/MS method for the quantitative detection of guazatine residues in cereals

artículo científico publicado en 2007

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

artículo científico publicado en 2017

Lennard-Jones potential and dummy atom settings to overcome the AUTODOCK limitation in treating flexible ring systems

scientific article published on 22 June 2007

Ligand-based virtual screening, parallel solution-phase and microwave-assisted synthesis as tools to identify and synthesize new inhibitors of mycobacterium tuberculosis

artículo científico publicado en 2006

Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs)

artículo científico publicado en 2004

Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase

artículo científico publicado en 2004

Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

artículo científico publicado en 2011

Modelling amphetamine/receptor interactions: a gas-phase study of complexes formed between amphetamine and Some chiral amido[4]resorcinarenes.

artículo científico publicado en 2008

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

artículo científico publicado en 2017

Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase.

artículo científico publicado en 2004

Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers

artículo científico publicado en 2010

Molecular dynamics and DFT study on HIV-1 nucleocapsid protein-7 in complex with viral genome.

artículo científico publicado en 2010

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions

artículo científico publicado en 2015

Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents

artículo científico

Molecular modeling as a powerful technique for understanding small-large molecules interactions.

artículo científico publicado en 2002

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

artículo científico publicado en 2016

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds

artículo científico publicado en 2008

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

artículo científico publicado en 2011

Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.

artículo científico publicado en 2016

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.

artículo científico publicado en 2017

New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.

artículo científico publicado en 2014

New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34(+) cells

artículo científico publicado en 2009

New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

artículo científico publicado en 2010

New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.

artículo científico publicado en 2003

Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach.

artículo científico publicado en 2012

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.

artículo científico publicado en 2011

Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species

artículo científico publicado en 2013

Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders ⬇️

artículo científico publicado el 11 de noviembre de 2010

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

artículo científico publicado en 2017

Novel broad spectrum virucidal molecules against enveloped viruses

scientific article published in PLoS ONE

Novel dual Src/Abl inhibitors for hematologic and solid malignancies

artículo científico publicado en 2010

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

artículo científico publicado en 2010

Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

artículo científico publicado en 2007

Novel hypotensive agents from Verbesina caracasana: structure, synthesis and pharmacology

artículo científico publicado en 2003

Novel substituted aminoalkylguanidines as potential antihyperglycemic and food intake-reducing agents

artículo científico publicado en 2008

Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors

scientific article published on 03 July 2007

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

artículo científico publicado en 2015

One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors

scientific article published on 10 December 2018

Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes

artículo científico publicado en 2007

Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity

artículo científico publicado en 2005

Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines

artículo científico publicado en 2005

Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models

artículo científico publicado en 2006

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

artículo científico publicado en 2008

Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands

artículo científico publicado en 2010

Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma

artículo científico publicado en 2018

Possible binding site for paclitaxel at microtubule pores.

artículo científico publicado en 2009

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

artículo científico publicado en 2017

Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives

artículo científico publicado en 2010

Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators.

artículo científico publicado en 2010

Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells

artículo científico publicado en 2020

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

artículo científico publicado en 2013

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses

artículo científico publicado en 2010

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart

scientific article published on 21 September 2018

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

artículo científico publicado en 2017

Protein kinases: docking and homology modeling reliability

artículo científico publicado en 2010

Protein-protein interactions and human cellular cofactors as new targets for HIV therapy

artículo científico

Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma

artículo científico publicado en 2014

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

artículo científico publicado en 2019

Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling

artículo científico publicado en 2007

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors

artículo científico publicado en 2013

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

artículo científico publicado en 2006

Pyrazolo[3,4-d]pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells

artículo científico publicado en 2006

Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells.

artículo científico publicado en 2004

Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.

artículo científico publicado en 2017

Raft component GD3 associates with tubulin following CD95/Fas ligation.

artículo científico publicado en 2009

Reactivity of lithium trimethylsilyldiazomethane and diazomethane toward the 5,6-double bond of uracil and uridine derivatives

Recent highlights in the synthesis of highly functionalized pyrimidines

artículo científico publicado en 2009

Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.

artículo científico publicado en 2003

Researches on antiviral agents. 3. synthesis and transformations of racemic and chiral 6-oxiranyl pyrimidinones

Resolution of (±)-1-Aryl-2-propynylamines via Acyltransfer Catalyzed byCandida antarcticaLipase ⬇️

artículo científico publicado el 14 de mayo de 1999

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

artículo científico publicado en 2018

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration.

artículo científico publicado en 2016

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

artículo científico publicado en 2015

SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment

artículo científico publicado en 2015

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

artículo científico publicado en 2006

Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization

artículo científico publicado en 2008

Small molecules modulation of 14-3-3 protein-protein interactions.

artículo científico

Small-molecule inhibitors of fibroblast growth factor receptor (FGFR) tyrosine kinases (TK).

artículo científico publicado en 2003

Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology

Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally "frozen" analogues of L-glutamic acid

artículo científico publicado en 2014

Stereoselective protecting group free synthesis of D,L-gulose ethyl glycoside via multicomponent enyne cross metathesis--hetero Diels-Alder reaction.

artículo científico publicado en 2009

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

artículo científico publicado en 2018

Structure prediction and validation of the ERK8 kinase domain

artículo científico publicado en 2013

Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update

artículo científico publicado en 2017

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

artículo científico publicado en 2017

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

artículo científico publicado en 2017

Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists

artículo científico publicado en 2008

Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

artículo científico publicado en 2008

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors

artículo científico publicado en 2015

Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity

artículo científico publicado en 2011

Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model

artículo científico publicado en 2008

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

artículo científico publicado en 2016

Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors

artículo científico publicado en 2005

Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs

scientific article published on 07 February 2020

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X

artículo científico publicado en 2019

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

article

Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists

artículo científico publicado en 2002

Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors.

artículo científico publicado en 2006

Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction

artículo científico publicado en 2018

Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase.

artículo científico publicado en 2009

Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.

artículo científico publicado en 2009

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.

artículo científico publicado en 2007

Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors

artículo científico publicado en 2006

Synthesis and interaction with copper(II) cations of cyano- and aminoresorcin[4]arenes

artículo científico publicado en 2002

Synthesis and molecular modelling studies of resorcin[4]arene-capped porphyrins.

artículo científico publicado en 2003

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

artículo científico publicado en 2005

Synthesis of C-Alkyl Calix[4]arenes. 3. Acid-Catalyzed Rearrangement of 2,6-Dimethoxycinnamate Prior to Tetramerization to Calix[4]arenes

artículo científico publicado en 1995

Synthesis of Enantiomerically Pure α-[4-(1-Substituted)-1,2,3-triazol-4-yl]-benzylacetamides via Microwave-Assisted Click Chemistry: Towards New Potential Antimicrobial Agents.

artículo científico publicado en 2007

Synthesis of an Original Oxygenated Taxuspine X Analogue: a Versatile “Non-Natural” Natural Product with Remarkable P-gp Modulating Activity

scientific article published on 01 May 2008

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1

scientific article published on 15 May 2019

Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents

Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity

scientific article published on 14 October 2014

Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp.

artículo científico publicado en 2009

Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides

Synthesis ofC-Alkylcalix[4]arenes. 5. Design, Synthesis, Computational Studies, and Homodimerization of Polymethylene-Bridged Resorc[4]arenes

artículo científico publicado en 1997

Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors

article

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis.

artículo científico publicado en 2008

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

artículo científico publicado en 2008

Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1 ⬇️

artículo científico publicado el 12 de noviembre de 2011

Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

artículo científico publicado en 2014

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.

artículo científico publicado en 2009

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

artículo científico publicado en 2008

Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides

artículo científico publicado en 2008

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

artículo científico publicado en 2008

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones

artículo científico publicado en 2008

Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists

artículo científico publicado en 2002

Synthetic SRC-kinase domain inhibitors and their structural requirements

artículo científico publicado en 2007

Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy

artículo científico publicado en 2011

Targets looking for drugs: a multistep computational protocol for the development of structure-based pharmacophores and their applications for hit discovery.

artículo científico publicado en 2008

Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

artículo científico publicado en 2016

The anti-HIV activity of ADS-J1 targets the HIV-1 gp120.

artículo científico publicado en 2005

The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors.

artículo científico publicado en 2013

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies

artículo científico publicado en 2007

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

artículo científico publicado en 2011

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

artículo científico publicado en 2008

Towards the discovery of new hypnotic agents: synthesis and preliminary pharmacological evaluation of a novel class of dibenzo[a,d]cycloheptene derivatives

artículo científico publicado en 2010

Unconventional plasticity of HIV-1 reverse transcriptase: how inhibitors could open a connection "gate" between allosteric and catalytic sites

artículo científico publicado en 2013

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.

artículo científico publicado en 2012

Using Insights into Pim1 Structure to Design New Anticancer Drugs ⬇️

artículo científico publicado el 1 de enero de 2010

alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds

artículo científico publicado en 2002

alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus

artículo científico publicado en 2003

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