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A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19

artículo científico publicado en 2020

A mechanism-based model for the population pharmacokinetics of free and bound aflibercept in healthy subjects

artículo científico

Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy

artículo científico publicado en 2005

Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group

scientific article published in 2022

Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial

artículo científico publicado en 2013

Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury

artículo científico publicado en 2012

Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection

scientific article published on 24 September 2018

Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques

artículo científico publicado en 2018

Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004.

artículo científico publicado en 2007

Assessment of pain during labor with pupillometry: a prospective observational study

artículo científico publicado en 2013

Assessment of the global two-stage method to EC50 determination ⬇️

artículo científico publicado el 1 de marzo de 1998

Association Between Tumor Size Kinetics and Survival in Patients With Urothelial Carcinoma Treated With Atezolizumab: Implication for Patient Follow-Up

scientific article published on 05 July 2019

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

artículo científico publicado en 2023

Bayesian Individual Dynamic Predictions with Uncertainty of Longitudinal Biomarkers and Risks of Survival Events in a Joint Modelling Framework: a Comparison Between Stan, Monolix, and NONMEM

artículo científico publicado en 2020

Benefit of therapeutic drug monitoring of protease inhibitors in HIV-infected patients depends on PI used in HAART regimen--ANRS 111 trial

artículo científico publicado en 2009

Bone events and evolution of biologic markers in Gaucher disease before and during treatment

artículo científico publicado en 2010

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

artículo científico publicado en 2021

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

artículo científico publicado en 2021

Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations

artículo científico publicado en 2013

Carriage of Methicillin-Resistant Staphylococcus aureus in Home Care Settings

scientific article published on 01 August 2009

Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens

scientific article published on 24 May 2019

Change in Bacterial Diversity of Fecal Microbiota Drives Mortality in a Hamster Model of Antibiotic-induced Clostridium difficile Colitis

artículo científico publicado en 2017

Ciprofloxacin dosage and emergence of resistance in human commensal bacteria

artículo científico publicado en 2009

Clinical and virological data of the first cases of COVID-19 in Europe: a case series

artículo científico publicado en 2020

Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

artículo científico publicado en 2013

Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593-606, Sep/Oct 2018, DOI: 10.1002/pst.1873

article

Comparison of Model Averaging and Model Selection in Dose Finding Trials Analyzed by Nonlinear Mixed Effect Models

artículo científico publicado en 2018

Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters

artículo científico publicado en 2008

Comparison of various phase I combination therapy designs in oncology for evaluation of early tumor shrinkage using simulations

artículo científico publicado en 2020

Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R.

artículo científico publicado en 2008

Correction: Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial.

artículo científico publicado en 2010

Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

artículo científico publicado en 2016

Correlation between fecal concentrations of ciprofloxacin and fecal counts of resistant Enterobacteriaceae in piglets treated with ciprofloxacin: toward new means to control the spread of resistance?

artículo científico publicado en 2012

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

scientific article published on 20 December 2019

Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.

artículo científico publicado en 2017

Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

artículo científico publicado en 2011

Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0.

artículo científico publicado en 2009

Design evaluation and optimization for models of hepatitis C viral dynamics.

artículo científico publicado en 2011

Design in nonlinear mixed effects models: optimization using the Fedorov-Wynn algorithm and power of the Wald test for binary covariates

artículo científico publicado en 2007

Development and evaluation of a score to predict difficult epidural placement during labor

artículo científico publicado en 2013

Different factors associated with CTX-M-producing ST131 and non-ST131 Escherichia coli clinical isolates

artículo científico publicado en 2013

Dolutegravir and lamivudine maintenance therapy in HIV-1 virologically suppressed patients: results of the ANRS 167 trial (LAMIDOL)

artículo científico publicado en 2019

Dose rationale for favipiravir use in patients infected with SARS-CoV-2

artículo científico publicado en 2020

Dose regimen of favipiravir for Ebola virus disease

artículo científico publicado en 2014

Drug assessment in the Ebola virus disease epidemic in West Africa

artículo científico publicado en 2015

Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials

artículo científico publicado en 2016

Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

artículo científico publicado en 2018

Ebola virus dynamics in mice treated with favipiravir

artículo científico publicado en 2015

Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients

artículo científico publicado en 2007

Effect of Oseltamivir, Zanamivir or Oseltamivir– Zanamivir Combination Treatments on Transmission of Influenza in Households ⬇️

artículo científico publicado el 7 de junio de 2012

Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials

artículo científico publicado en 2023

Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial ⬇️

artículo científico publicado el 2 de noviembre de 2010

Efficacy of cloxacillin versus cefazolin for methicillin-susceptible bacteraemia (CloCeBa): study protocol for a randomised, controlled, non-inferiority trial

article

Efficient model-based bioequivalence testing

artículo científico publicado en 2020

Electronic sensors for assessing interactions between healthcare workers and patients under airborne precautions

artículo científico publicado en 2012

Emergence of resistance in normal human aerobic commensal flora during telithromycin and amoxicillin-clavulanic acid treatments

artículo científico publicado en 2003

Endpoints for randomized controlled clinical trials for COVID-19 treatments

artículo científico publicado en 2020

Enhanced saquinavir exposure in human immunodeficiency virus type 1-infected patients with diarrhea and/or wasting syndrome.

artículo científico publicado en 2004

Erratum for Madelain et al., "Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses".

artículo científico publicado en 2017

Escherichia coli bacteremia in children: age and portal of entry are the main predictors of severity.

artículo científico publicado en 2014

Estimation of population pharmacokinetic parameters of saquinavir in HIV patients with the MONOLIX software

artículo científico publicado en 2007

Evaluation by simulation of tests based on non-linear mixed-effects models in pharmacokinetic interaction and bioequivalence cross-over trials

artículo científico publicado en 2005

Evaluation of different tests based on observations for external model evaluation of population analyses

artículo científico publicado en 2009

Evaluation of estimation methods and power of tests of discrete covariates in repeated time-to-event parametric models: application to Gaucher patients treated by imiglucerase

artículo científico publicado en 2014

Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs

artículo científico publicado en 2004

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

artículo científico publicado en 2016

Extension of NPDE for evaluation of nonlinear mixed effect models in presence of data below the quantification limit with applications to HIV dynamic model

artículo científico publicado en 2012

Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

artículo científico publicado en 2016

Favipiravir for children with Ebola

artículo científico publicado en 2015

Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

artículo científico publicado en 2017

Finding optimal design in nonlinear mixed effect models using multiplicative algorithms

artículo científico publicado en 2021

Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics

artículo científico publicado en 2002

Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2009

Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics ⬇️

artículo científico publicado el 1 de mayo de 2003

Heparin bridging therapy and bleeding events in octogenarian inpatients with atrial fibrillation starting anticoagulation: results of an ancillary study

artículo científico publicado en 2011

High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy

artículo científico publicado en 2005

Host Factors and Portal of Entry Outweigh Bacterial Determinants To Predict the Severity of Escherichia coli Bacteremia ⬇️

artículo científico publicado el 22 de diciembre de 2010

Impact of Antibiotic Gut Exposure on the Temporal Changes in Microbiome Diversity

scientific article published on 23 September 2019

Impact of imiglucerase on the serum glycosylated-ferritin level in Gaucher disease

scientific article published on 16 November 2010

Impact of modelling intra-subject variability on tests based on non-linear mixed-effects models in cross-over pharmacokinetic trials with application to the interaction of tenofovir on atazanavir in HIV patients

artículo científico publicado en 2007

Implementation and Evaluation of the SAEM Algorithm for Longitudinal Ordered Categorical Data with an Illustration in Pharmacokinetics–Pharmacodynamics ⬇️

artículo científico publicado el 11 de noviembre de 2010

Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations

artículo científico publicado en 2017

Indinavir plasma concentration and adherence score are codeterminant of early virologic response in HIV-infected patients of the APROCO cohort

artículo científico publicado en 2005

Indinavir trough concentration as a determinant of early nephrolithiasis in HIV-1-infected adults

scientific article published on 01 April 2007

Influence of pharmacogenetics on indinavir disposition and short-term response in HIV patients initiating HAART

artículo científico publicado en 2009

Intra-monocyte Pharmacokinetics of Imiglucerase Supports a Possible Personalized Management of Gaucher Disease Type 1

artículo científico publicado en 2019

Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action

artículo científico publicado en 2010

Is the length of postoperative recurrence on the neo ileum terminal ileum predictable in Crohn's disease? ⬇️

artículo científico publicado el 16 de octubre de 2010

Joint Population Pharmacokinetic Analysis of Zidovudine, Lamivudine, and Their Active Intracellular Metabolites in HIV Patients ⬇️

artículo científico publicado el 16 de mayo de 2011

Late results of percutaneous mitral commissurotomy up to 20 years: development and validation of a risk score predicting late functional results from a series of 912 patients.

artículo científico publicado en 2012

Mathematical modeling of bacterial kinetics to predict the impact of antibiotic colonic exposure and treatment duration on the amount of resistant enterobacteria excreted

artículo científico publicado en 2014

Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics studies.

artículo científico publicado en 2015

Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide

artículo científico publicado en 2006

Model Averaging in Viral Dynamic Models

artículo científico publicado en 2020

Model-based analyses of bioequivalence crossover trials using the stochastic approximation expectation maximisation algorithm

artículo científico publicado en 2011

Modeling changes in biomarkers in Gaucher disease patients receiving enzyme replacement therapy using a pathophysiological model

artículo científico publicado en 2014

Modeling favipiravir antiviral efficacy against emerging viruses: from animal studies to clinical trials

scientific article published on 20 March 2020

Modeling the effect of DAV132, a novel colon-targeted adsorbent, on fecal concentrations of moxifloxacin and gut microbiota diversity in healthy volunteers

artículo científico publicado en 2020

Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters

artículo científico publicado en 2007

Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy

artículo científico publicado en 2020

Nonlinear Mixed-effect Models for Prostate-specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: A Comparison by Simulation of Two-stage and Joint Approaches.

artículo científico publicado en 2015

Nonlinear joint models for individual dynamic prediction of risk of death using Hamiltonian Monte Carlo: application to metastatic prostate cancer

artículo científico

Once-daily dosing of saquinavir soft-gel capsules and ritonavir combination in HIV-1-infected patients (IMEA015 study).

artículo científico publicado en 2004

Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression ⬇️

artículo científico publicado el 9 de septiembre de 2010

Optimization of individual and population designs using Splus

artículo científico publicado en 2003

PFIM 4.0, an extended R program for design evaluation and optimization in nonlinear mixed-effect models

artículo científico publicado en 2018

Patient's origin and lifestyle associated with CTX-M-producing Escherichia coli: a case-control-control study

artículo científico publicado en 2012

Persistent low-level HIV-1 RNA between 20 and 50 copies/mL in antiretroviral-treated patients: associated factors and virological outcome

artículo científico publicado en 2012

Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling ⬇️

artículo científico publicado el 28 de diciembre de 2011

Pharmacokinetic analysis of mizolastine in healthy young volunteers after single oral and intravenous doses: noncompartmental approach and compartmental modeling

artículo científico publicado el 1 de abril de 1997

Pharmacokinetic and Pharmacodynamic Variability of Fluindione in Octogenarians ⬇️

artículo científico publicado el 1 de mayo de 2012

Pharmacokinetics and neutrophil toxicity of paclitaxel orally administered in mice with recombinant interleukin-2

scientific article published on 16 September 2004

Pharmacokinetics of propofol administered by target-controlled infusion to alcoholic patients

artículo científico publicado en 2003

Phase II Study of Cetuximab As First-Line Single-Drug Therapy in Patients With Unresectable Squamous Cell Carcinoma of the Skin

article

Phylogenetic distribution of CTX-M- and non-extended-spectrum-β-lactamase-producing Escherichia coli isolates: group B2 isolates, except clone ST131, rarely produce CTX-M enzymes.

artículo científico publicado en 2012

Phylogenetic, virulence and antibiotic resistance characteristics of commensal strain populations of Escherichia coli from community subjects in the Paris area in 2010 and evolution over 30 years.

artículo científico publicado en 2016

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder.

artículo científico publicado en 2014

Population pharmacodynamic analysis of octreotide in acromegalic patients

artículo científico publicado en 2003

Population pharmacokinetic analysis of free and bound aflibercept in patients with advanced solid tumors

artículo científico publicado en 2013

Population pharmacokinetic analysis of indinavir in HIV-infected patient treated with a stable antiretroviral therapy

artículo científico publicado en 2005

Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.

artículo científico publicado en 2007

Population pharmacokinetic analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method

artículo científico publicado el 1 de abril de 1998

Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients*

artículo científico publicado el 1 de enero de 1998

Population pharmacokinetics of clozapine evaluated with the nonparametric maximum likelihood method ⬇️

artículo científico publicado el 1 de noviembre de 1997

Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens

artículo científico publicado en 2014

Prediction of movement to surgical stimulation by the pupillary dilatation reflex amplitude evoked by a standardized noxious test

artículo científico publicado en 2015

Prediction of shrinkage of individual parameters using the bayesian information matrix in non-linear mixed effect models with evaluation in pharmacokinetics.

artículo científico publicado en 2013

Preventive services recommendations for adults in primary care settings: agreement between Canada, France and the USA--a systematic review

artículo científico publicado en 2013

Profile of French general practitioners providing opportunistic primary preventive care--an observational cross-sectional multicentre study

artículo científico publicado en 2014

Protection of hamsters from mortality by reducing fecal moxifloxacin concentration with DAV131A in a model of moxifloxacin-induced Clostridium difficile colitis

artículo científico publicado en 2017

Protection of the Human Gut Microbiome From Antibiotics

artículo científico publicado en 2017

Protection of the human gut microbiome from antibiotics

artículo científico publicado en 2017

Rapid and simple micromethod for the quantification of fluindione in human plasma using high-performance liquid chromatography ⬇️

artículo científico publicado el 10 de abril de 1998

Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial

artículo científico publicado en 2020

Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial-authors' response

artículo científico publicado en 2020

Relationship between exposure to zidovudine and decrease of P24 antigenemia in HIV-infected patients in monotherapy

scientific article published on 01 October 2002

Reporting and Methodology of Multivariable Analyses in Prognostic Observational Studies Published in 4 Anesthesiology Journals: A Methodological Descriptive Review.

artículo científico publicado en 2014

Review and methodological analysis of trials currently testing treatment and prevention options for the novel coronavirus disease (COVID-19) globally.

artículo científico publicado en 2020

Review of trials currently testing treatment and prevention of COVID-19

artículo científico publicado en 2020

Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates

scientific article published on 02 March 2020

S10.3c Clinical studies provide new insights on the association between the microbiota and host resistance to <i>Candida albicans</i> intestinal colonization

artículo científico publicado en 2022

Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.

artículo científico publicado en 2014

The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients

artículo científico publicado en 2012

The safety profile of favipiravir should not be the first argument to suspend its evaluation in viral hemorrhagic fevers

scientific article published on 25 June 2020

The value of open-source clinical science in pandemic response: lessons from ISARIC

artículo científico publicado en 2021

Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load

scientific article published on 18 June 2020

Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load

artículo científico publicado en 2020

Timing of β-Blocker Reintroduction and the Occurrence of Postoperative Atrial Fibrillation after Cardiac Surgery: A Prospective Cohort Study

scientific article published on 16 December 2019

Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin

scientific article published on 10 February 2015

Type 1 interferons as a potential treatment against COVID-19

artículo científico publicado en 2020

Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir, and pegylated interferon during triple therapy in treatment-experienced hepatitis C virus-infected cirrhotic patients

artículo científico publicado en 2014

Using the SAEM algorithm for mechanistic joint models characterizing the relationship between nonlinear PSA kinetics and survival in prostate cancer patients

artículo científico publicado en 2016

Why should prediction discrepancies be renamed standardized visual predictive check?

artículo científico publicado en 2011

[Adherence intervention for HIV-infected patients receiving antiretroviral treatment. Implementation and initial assessment]

artículo científico publicado en 2006

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