Lista de obras - Savita Khanna - Dominio Público Uruguay

A Modified Collagen Dressing Induces Transition of Inflammatory to Reparative Phenotype of Wound Macrophages

artículo científico publicado en 2019

A modified collagen gel dressing promotes angiogenesis in a preclinical swine model of chronic ischemic wounds

artículo científico publicado en 2014

A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds ⬇️

artículo científico publicado en 2013

Abstract 73: MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4/MCP-1 Pathway

artículo científico publicado en 2014

Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes

scientific journal article

Ad hoc hybrid synaptic junctions to detect nerve stimulation and its application to detect onset of diabetic polyneuropathy

artículo científico publicado en 2020

Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.

artículo científico publicado en 2007

Alpha‐lipoic acid does not alter stress protein response to acute exercise in diabetic brain ⬇️

artículo científico publicado el 29 de octubre de 2010

An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment

scientific article published on January 2011

Anti-angiogenic property of edible berries

artículo científico publicado en 2002

AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing

artículo científico publicado en 2016

Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing

artículo científico publicado en 2007

Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes

artículo científico publicado en 2015

Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement

artículo científico publicado en 2004

Characterization of a preclinical model of chronic ischemic wound.

artículo científico publicado en 2009

Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.

artículo científico publicado en 2003

Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome

artículo científico publicado en 2008

Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol

artículo científico publicado en 2006

Copper-induced vascular endothelial growth factor expression and wound healing

artículo científico publicado en 2002

Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status-Dependent Manner

scientific article published on 22 August 2019

Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.

artículo científico publicado en 2005

Dermal wound healing is subject to redox control

artículo científico publicado en 2005

Dermal wound healing properties of redox-active grape seed proanthocyanidins

artículo científico publicado en 2002

Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers

artículo científico publicado en 2015

Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain

artículo científico publicado en 2008

Dicer knockdown inhibits endothelial cell tumor growth via microRNA 21a-3p targeting of Nox-4.

artículo científico publicado en 2014

Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue.

artículo científico publicado en 2018

Does oral supplementation of a fermented papaya preparation correct respiratory burst function of innate immune cells in type 2 diabetes mellitus patients?

artículo científico publicado en 2014

Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2 ⬇️

artículo científico publicado el 12 de abril de 2012

Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing

artículo científico publicado en 2017

Electroceutical Fabric Lowers Zeta Potential and Eradicates Coronavirus Infectivity upon Contact

Endothelial cell tumor growth is Ape/ref-1 dependent

artículo científico publicado en 2015

Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation

artículo científico publicado en 2014

Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

artículo científico publicado en 2017

Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy.

artículo científico publicado en 2017

Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells

artículo científico publicado en 2008

Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke

artículo científico publicado en 2014

Exercise training modulates heat shock protein response in diabetic rats

artículo científico publicado en 2004

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts

artículo científico publicado en 2010

Functional genomics: high-density oligonucleotide arrays

scientific article published on 01 January 2002

Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain

artículo científico publicado en 2017

Glutamate-induced c-Src activation in neuronal cells

artículo científico publicado en 2002

Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation

artículo científico publicado en 2006

High-frequency high-resolution echocardiography: first evidence on non-invasive repeated measure of myocardial strain, contractility, and mitral regurgitation in the ischemia-reperfused murine heart

artículo científico publicado en 2010

Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.

artículo científico

Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds

artículo científico publicado en 2010

Improvement of human keratinocyte migration by a redox active bioelectric dressing

artículo científico publicado en 2014

Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke

artículo científico publicado en 2015

Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes

artículo científico publicado en 2006

Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.

artículo científico publicado en 2013

Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice

artículo científico publicado en 2010

May Dietary Supplementation Augment Respiratory Burst in Wound-site Inflammatory Cells?

artículo científico publicado en 2017

MicroRNA Regulation of Oxidative Stress

artículo científico publicado en 2017

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

artículo científico publicado en 2009

MicroRNA in cutaneous wound healing: a new paradigm

artículo científico publicado en 2007

MicroRNA in ischemic stroke etiology and pathology

artículo científico publicado en 2010

Micromanaging vascular biology: tiny microRNAs play big band

artículo científico publicado en 2009

Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines

artículo científico publicado en 2008

Mitochondria as Target for Tumor Management of Hemangioendothelioma

artículo científico publicado en 2020

Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function

artículo científico publicado en 2014

Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

artículo científico publicado en 2003

Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells

artículo científico publicado en 2016

Multidrug resistance-associated protein-1 (MRP-1)-dependent glutathione disulfide (GSSG) efflux as a critical survival factor for oxidant-enriched tumorigenic endothelial cells

artículo científico publicado en 2016

Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.

artículo científico publicado en 2009

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1 ⬇️

artículo científico publicado el 30 de junio de 2011

Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal

artículo científico publicado en 2006

Neurogenic tissue Nanotransfection in the Management of Cutaneous Diabetic Polyneuropathy

scientific article published on 15 May 2020

Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid.

artículo científico publicado en 2009

Neuroprotective properties of the natural vitamin E alpha-tocotrienol

artículo científico publicado en 2005

Novel Bacterial Diversity and Fragmented eDNA Identified in Hyperbiofilm-Forming Pseudomonas aeruginosa Rugose Small Colony Variant

scientific article published on 09 January 2020

Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation

artículo científico publicado en 2018

Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm

artículo científico publicado en 2009

Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients

artículo científico publicado en 2012

Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing

artículo científico publicado en 2002

Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1).

artículo científico publicado en 2003

Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm

artículo científico publicado en 2002

Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke.

artículo científico publicado en 2011

Oxygen-sensitive outcomes and gene expression in acute ischemic stroke

artículo científico publicado en 2010

Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point

artículo científico publicado en 2006

Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress.

artículo científico publicado en 2005

P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts

artículo científico publicado en 2007

Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease

artículo científico publicado en 2010

Particulate β‐glucan induces TNF‐α production in wound macrophages via a redox‐sensitive NF‐κβ‐dependent pathway ⬇️

artículo científico publicado el 21 de abril de 2011

Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart

artículo científico publicado en 2006

Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart

scientific article published on 01 January 2004

Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system?

artículo científico publicado en 2003

Phytoestrogen isoflavone intervention to engage the neuroprotective effect of glutamate oxaloacetate transaminase against stroke.

artículo científico publicado en 2017

Platelet‐rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation ⬇️

artículo científico publicado el 1 de noviembre de 2011

Postprandial levels of the natural vitamin E tocotrienol in human circulation

artículo científico publicado en 2006

Prostaglandin E₂ induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway ⬇️

artículo científico publicado el 27 de julio de 2012

Proteomic analysis of the mammalian cell nucleus

artículo científico publicado en 2004

Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.

artículo científico publicado en 2008

Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing

artículo científico publicado en 2007

Regulation of c-Src activity in glutamate-induced neurodegeneration

artículo científico publicado en 2007

Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia

scientific article published on 01 March 2006

Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation.

artículo científico publicado en 2017

Robot-assisted mechanical therapy attenuates stroke-induced limb skeletal muscle injury.

artículo científico publicado en 2016

Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries.

artículo científico publicado en 2006

Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke.

artículo científico publicado en 2010

Silver-zinc redox-coupled electroceutical wound dressing disrupts bacterial biofilm

artículo científico publicado en 2015

Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC-coulometric electrode array

scientific article published on 01 January 2002

Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms

scientific article published on 04 June 2019

Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen

scientific article published on 03 January 2019

Supplementation of a standardized extract from Phyllanthus emblica improves cardiovascular risk factors and platelet aggregation in overweight/class-1 obese adults.

artículo científico publicado en 2015

Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction

artículo científico publicado en 2013

Survival surgery for coronary occlusion and reoxygenation in a rodent model

scientific article published on 01 January 2004

The MicroRNA miR-199a-5p Down-regulation Switches on Wound Angiogenesis by Derepressing the v-ets Erythroblastosis Virus E26 Oncogene Homolog 1-Matrix Metalloproteinase-1 Pathway ⬇️

artículo científico publicado el 11 de octubre de 2012

Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis.

artículo científico publicado en 2011

Tocotrienol: the natural vitamin E to defend the nervous system?

artículo científico publicado en 2004

Tocotrienols in health and disease: the other half of the natural vitamin E family

artículo científico publicado en 2007

Tocotrienols: Vitamin E beyond tocopherols

artículo científico publicado en 2006

Tocotrienols: the emerging face of natural vitamin E

artículo científico publicado en 2007

Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds

artículo científico publicado en 2008

Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue

artículo científico publicado en 2017

Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.

artículo científico publicado en 2006

Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement

artículo científico publicado en 2007

Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium

artículo científico publicado en 2006

Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue

artículo científico publicado en 2007

Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation

artículo científico publicado en 2017

Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1

artículo científico publicado en 2020

Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis

artículo científico publicado en 2002

Would Healing: oxygen and emerging therapeutics. Columbus, Ohio, September 12-15, 2002

artículo científico publicado en 2002

Wound site neutrophil transcriptome in response to psychological stress in young men.

artículo científico publicado en 2005

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells ⬇️

artículo científico publicado el 16 de noviembre de 2010

Lista de obras de Savita Khanna

A Modified Collagen Dressing Induces Transition of Inflammatory to Reparative Phenotype of Wound Macrophages

A modified collagen gel dressing promotes angiogenesis in a preclinical swine model of chronic ischemic wounds

A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds ⬇️

Abstract 73: MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4/MCP-1 Pathway

Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes

Ad hoc hybrid synaptic junctions to detect nerve stimulation and its application to detect onset of diabetic polyneuropathy

Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.

Alpha‐lipoic acid does not alter stress protein response to acute exercise in diabetic brain ⬇️

An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment

Anti-angiogenic property of edible berries

AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing

Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing

Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes

Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement

Characterization of a preclinical model of chronic ischemic wound.

Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.

Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome

Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol

Copper-induced vascular endothelial growth factor expression and wound healing

Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status-Dependent Manner

Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.

Dermal wound healing is subject to redox control

Dermal wound healing properties of redox-active grape seed proanthocyanidins

Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers

Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain

Dicer knockdown inhibits endothelial cell tumor growth via microRNA 21a-3p targeting of Nox-4.

Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue.

Does oral supplementation of a fermented papaya preparation correct respiratory burst function of innate immune cells in type 2 diabetes mellitus patients?

Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2 ⬇️

Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing

Electroceutical Fabric Lowers Zeta Potential and Eradicates Coronavirus Infectivity upon Contact

Endothelial cell tumor growth is Ape/ref-1 dependent

Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation

Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy.

Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells

Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke

Exercise training modulates heat shock protein response in diabetic rats

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts

Functional genomics: high-density oligonucleotide arrays

Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain

Glutamate-induced c-Src activation in neuronal cells

Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation

High-frequency high-resolution echocardiography: first evidence on non-invasive repeated measure of myocardial strain, contractility, and mitral regurgitation in the ischemia-reperfused murine heart

Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.

Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds

Improvement of human keratinocyte migration by a redox active bioelectric dressing

Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke

Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes

Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.

Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice

May Dietary Supplementation Augment Respiratory Burst in Wound-site Inflammatory Cells?

MicroRNA Regulation of Oxidative Stress

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

MicroRNA in cutaneous wound healing: a new paradigm

MicroRNA in ischemic stroke etiology and pathology

Micromanaging vascular biology: tiny microRNAs play big band

Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines

Mitochondria as Target for Tumor Management of Hemangioendothelioma

Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function

Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells

Multidrug resistance-associated protein-1 (MRP-1)-dependent glutathione disulfide (GSSG) efflux as a critical survival factor for oxidant-enriched tumorigenic endothelial cells

Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1 ⬇️

Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal

Neurogenic tissue Nanotransfection in the Management of Cutaneous Diabetic Polyneuropathy

Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid.

Neuroprotective properties of the natural vitamin E alpha-tocotrienol

Novel Bacterial Diversity and Fragmented eDNA Identified in Hyperbiofilm-Forming Pseudomonas aeruginosa Rugose Small Colony Variant

Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation

Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm

Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients

Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing

Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1).

Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm

Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke.

Oxygen-sensitive outcomes and gene expression in acute ischemic stroke

Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point