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4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion

artículo científico publicado en 2009

A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application

artículo científico publicado en 2016

A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer

artículo científico publicado en 2016

A General Solid Phase Method for the Preparation of Diverse Azapeptide Probes Directed Against Cysteine Proteases

artículo científico publicado en 2005

A Mild Chemically Cleavable Linker System for Functional Proteomic Applications

scientific article published on 01 January 2007

A Substrate-Inspired Probe Monitors Translocation, Activation, and Subcellular Targeting of Bacterial Type III Effector Protease AvrPphB

artículo científico publicado en 2013

A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals

artículo científico publicado en 2014

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.

artículo científico publicado en 2013

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

scientific journal article

A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases

artículo científico publicado en 2013

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite

artículo científico publicado en 2011

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

artículo científico publicado en 2009

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages

artículo científico publicado en 2012

A proteolytic system that compensates for loss of proteasome function

artículo científico publicado el 9 de abril de 1998

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

artículo científico publicado en 2002

A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.

artículo científico publicado en 2006

A small-molecule antivirulence agent for treating Clostridium difficile infection

artículo científico publicado en 2015

AND-gate contrast agents for enhanced fluorescence-guided surgery

artículo científico publicado en 2020

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins

artículo científico publicado en 2013

Active cathepsins B, L, and S in murine and human pancreatitis

artículo científico publicado en 2012

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

artículo científico publicado el 1 de noviembre de 2001

Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.

artículo científico publicado en 2007

Activity profiling of papain-like cysteine proteases in plants

artículo científico publicado en 2004

Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection.

artículo científico publicado en 2012

Activity-based probes as a tool for functional proteomic analysis of proteases.

artículo científico publicado en 2008

Activity-based probes for the multicatalytic proteasome

artículo científico publicado en 2017

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights

artículo científico publicado en 2017

Activity-based probes that target diverse cysteine protease families

artículo científico publicado en 2005

Activity-based profiling of proteases

artículo científico publicado en 2014

Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

artículo científico publicado en 2004

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors

artículo científico publicado en 2009

An Improved Preparation of the Activity-Based Probe JPM-OEt and In Situ Applications

An in vivo multiplexed small-molecule screening platform

artículo científico publicado en 2016

An optimized activity-based probe for the study of caspase-6 activation

artículo científico publicado en 2012

Application of activity-based probes to the study of enzymes involved in cancer progression

artículo científico publicado en 2008

Applications for chemical probes of proteolytic activity

artículo científico publicado en 2004

Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses

artículo científico publicado en 2013

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes

artículo científico publicado en 2014

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

artículo científico publicado en 2009

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

artículo científico publicado en 2012

Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection

artículo científico publicado en 2016

Biochemical analysis of the 20 S proteasome of Trypanosoma brucei

artículo científico publicado en 2003

Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1

artículo científico publicado en 2010

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase

artículo científico publicado en 2015

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

artículo científico publicado en 2012

Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

artículo científico publicado en 2012

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

artículo científico publicado en 2009

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion

artículo científico publicado en 2016

Cathepsin B trafficking in thyroid carcinoma cells

artículo científico publicado en 2011

Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones

artículo científico publicado en 2004

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

artículo científico publicado en 2003

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice

artículo científico publicado en 2011

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.

artículo científico publicado en 2004

Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts

artículo científico publicado en 2010

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

artículo científico publicado en 2004

Characteristics of the caspase-like catalytic domain of human paracaspase.

artículo científico publicado en 2004

Chemical Strategies To Target Bacterial Virulence

artículo científico publicado en 2017

Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models

scientific article published on 11 September 2018

Chemical approaches for functionally probing the proteome

artículo científico publicado en 2002

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

artículo científico publicado en 2011

Chemical proteomics and its application to drug discovery

artículo científico publicado en 2003

Chemical proteomics and its application to drug discovery

Chemical proteomics applied to target identification and drug discovery

artículo científico publicado en 2005

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

scientific article published on 01 December 2006

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

artículo científico publicado en 2009

Correction: Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

artículo científico publicado en 2016

Correction: Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope

scientific article published in PLoS ONE

Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity

artículo científico publicado en 2013

Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence

artículo científico publicado en 2019

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

scientific article published on 06 June 2019

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

artículo científico publicado en 2016

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

artículo científico publicado en 2015

Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion

artículo científico publicado en 2006

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

artículo científico publicado en 2011

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

scientific article published on 29 August 2018

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

artículo científico publicado en 2017

Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.

artículo científico publicado en 2015

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

artículo científico publicado en 2015

Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain

artículo científico publicado en 2006

Design, syntheses, and evaluation of Taspase1 inhibitors

artículo científico publicado en 2009

Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases

artículo científico publicado en 2007

Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes

article published in 2016

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins

artículo científico publicado en 2015

Development of activity-based probes for cathepsin X.

artículo científico publicado en 2011

Development of activity-based probes for trypsin-family serine proteases

artículo científico publicado en 2006

Development of an activity-based probe for acyl-protein thioesterases

artículo científico publicado en 2018

Development of calpain-specific inactivators by screening of positional scanning epoxide libraries

artículo científico publicado en 2007

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain

artículo científico publicado en 2010

Development of small molecule inhibitors and probes of human SUMO deconjugating proteases

artículo científico publicado en 2011

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

artículo científico publicado en 2012

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

artículo científico publicado en 2016

Dissecting Protein Function Using Chemical Proteomic Methods

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

artículo científico publicado en 2005

Engineered hybrid dimers: tracking the activation pathway of caspase-7.

artículo científico publicado en 2006

Enzyme activity--it's all about image

artículo científico publicado en 2004

Erratum for Foe et al., “The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture”

artículo científico publicado en 2018

Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases

artículo científico publicado en 2008

Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion

artículo científico publicado en 2006

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

scientific article published on 07 August 2011

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo

scientific article published on 21 October 2013

Finding enzymes that are actively involved in cancer

artículo científico publicado en 2010

Finding the needles in the haystack: mapping constitutive proteolytic events in vivo

artículo científico publicado en 2007

Fluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus

artículo científico publicado en 2019

Friend or foe? Turning a host defense protein into a pathogen's accomplice.

artículo científico publicado en 2008

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.

artículo científico publicado en 2017

Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors

artículo científico publicado en 2011

Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase

artículo científico publicado en 2003

Functional imaging of legumain in cancer using a new quenched activity-based probe

artículo científico publicado en 2012

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

artículo científico publicado el 16 de noviembre de 2011

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes

artículo científico publicado en 2010

Genomics and proteomics

artículo científico publicado en 2007

Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.

artículo científico publicado en 2015

Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte

artículo científico publicado en 2010

Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis

artículo científico

Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

artículo científico publicado en 2009

Highlight: the universe of proteolytic networks and mechanisms

scientific article published on 01 September 2012

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

scientific article published on 16 May 2018

Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis

scientific journal article

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

artículo científico publicado en 2013

Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes

artículo científico publicado en 2006

Identification of highly selective covalent inhibitors by phage display

artículo científico publicado en 2020

Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome

artículo científico publicado en 2014

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

artículo científico publicado en 2008

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity

scientific article published on 19 September 2013

In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes

artículo científico publicado en 2013

Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

artículo científico publicado en 2007

Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages

scientific journal article

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

artículo científico publicado en 2017

Influenza A virus elevates active cathepsin B in primary murine DC.

artículo científico publicado en 2007

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

artículo científico publicado en 2017

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

artículo científico publicado en 2005

Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer

artículo científico publicado en 2007

Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus

artículo científico publicado en 2007

Introduction to the Special Issue on Proteases and Proteolysis in Health and Disease

artículo científico publicado en 2017

IrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus

artículo científico publicado en 2007

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

artículo científico publicado en 2015

Legumain is activated in macrophages during pancreatitis

artículo científico publicado en 2016

Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease

scientific article published on 10 September 2019

Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe

artículo científico publicado en 2017

Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation

artículo científico publicado en 2009

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin

artículo científico publicado en 2009

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

artículo científico publicado en 2016

Metabolomics cuts to the chase to chase the cuts

artículo científico publicado en 2009

Metalloproteases see the light

artículo científico publicado en 2006

Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity

artículo científico publicado en 2014

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

artículo científico publicado en 2008

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

artículo científico publicado en 2015

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion

artículo científico publicado en 2017

New Blood Test SEEKs To Detect and Localize Cancer before It's Too Late

artículo científico publicado en 2018

New approaches for dissecting protease functions to improve probe development and drug discovery

artículo científico publicado en 2012

New technologies and their impact on 'omics' research

artículo científico publicado en 2013

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes

artículo científico publicado en 2016

Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe

artículo científico publicado en 2011

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

artículo científico publicado en 2009

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

artículo científico publicado en 2007

Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases

artículo científico publicado en 2006

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

artículo científico publicado en 2010

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

artículo científico publicado en 2011

Optimization of a Protease Activated Probe for Optical Surgical Navigation.

artículo científico publicado en 2017

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

article by Chaido Stathopoulou et al published 21 August 2018 in Immunity

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production

artículo científico publicado en 2002

Phosphoramidates as Novel Activity-Based Probes for Serine Proteases

scholarly article by Ute R. Haedke published in May 2014

Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets

artículo científico publicado en 2013

Pre-Trained Deep Convolutional Neural Network for Clostridioides Difficile Bacteria Cytotoxicity Classification Based on Fluorescence Images

artículo científico publicado en 2020

Probes to monitor activity of the paracaspase MALT1.

artículo científico publicado en 2014

Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.

artículo científico publicado en 2002

Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe

artículo científico publicado en 2020

Proteases as regulators of pathogenesis: examples from the Apicomplexa.

artículo científico publicado en 2011

Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum

artículo científico publicado el 20 de marzo de 1998

Proteasome inhibitors and antigen presentation

artículo científico publicado el 1 de enero de 1997

Protein Degradation Systems as Antimalarial Therapeutic Targets

artículo científico publicado en 2017

Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis

scientific article published on 15 June 2019

Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance

artículo científico publicado en 2012

Proteomics evaluation of chemically cleavable activity-based probes

artículo científico publicado en 2007

Proteomics meets microbiology: technical advances in the global mapping of protein expression and function

artículo científico publicado en 2005

Rab35 controls actin bundling by recruiting fascin as an effector protein.

artículo científico publicado en 2009

Rapid visualization of nonmelanoma skin cancer.

artículo científico publicado en 2016

Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

artículo científico publicado en 2010

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

artículo científico publicado en 2003

Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

artículo científico publicado en 2016

Screening for selective small molecule inhibitors of the proteasome using activity-based probes

artículo científico publicado en 2005

Sequential autolytic processing activates the zymogen of Arg-gingipain

artículo científico publicado en 2003

Short-Wave Infrared Fluorescence Chemical Sensor for Detection of Otitis Media

artículo científico publicado en 2020

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag

artículo científico publicado en 2009

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

artículo científico publicado en 2008

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design

artículo científico publicado en 2002

Solid-phase methods for the preparation of epoxysuccinate-based inhibitors of cysteine proteases.

artículo científico publicado en 2006

Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.

artículo científico publicado en 2005

Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus

scientific article published on 15 September 2020

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

artículo científico publicado en 2012

Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

artículo científico publicado en 2015

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

artículo científico publicado el 1 de junio de 1998

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

artículo científico publicado en 2006

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

artículo científico publicado en 2011

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries

artículo científico publicado en 2002

Substrate specificity of transthyretin: identification of natural substrates in the nervous system

artículo científico publicado en 2009

Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report

artículo científico publicado en 2015

Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain

artículo científico publicado el 21 de diciembre de 2011

Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases

artículo científico publicado en 2018

Synthetic and biological approaches to map substrate specificities of proteases

artículo científico publicado en 2019

TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

artículo científico publicado en 2018

Tagging and detection strategies for activity-based proteomics.

artículo científico publicado en 2006

Target deconvolution techniques in modern phenotypic profiling

artículo científico publicado el 18 de enero de 2013

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

artículo científico publicado en 2004

The Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture

article by Ian T Foe et al published 19 September 2018 in mSphere

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

artículo científico publicado en 2012

The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells

artículo científico publicado en 2013

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis

scientific article published on 22 September 2020

The lysosomal protein cathepsin L is a progranulin protease

artículo científico publicado en 2017

The protease cathepsin L regulates Th17 cell differentiation

artículo científico publicado en 2015

The role of cathepsin X in the migration and invasiveness of T lymphocytes

artículo científico publicado en 2008

Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins

artículo científico publicado en 2012

Topical application of activity-based probes for visualization of brain tumor tissue

artículo científico publicado en 2012

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

artículo científico publicado en 2017

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

artículo científico publicado en 2017

Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl

artículo científico publicado en 2009

Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model

artículo científico publicado en 2011

Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum

scientific article published on 11 July 2019

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.

artículo científico publicado en 2008

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

artículo científico publicado en 2015

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

artículo científico publicado en 2006

Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa

artículo científico publicado en 2007

Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.

artículo científico publicado en 2010

Using small molecules to dissect mechanisms of microbial pathogenesis

artículo científico publicado en 2009

VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation

artículo científico publicado en 2009

Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope

artículo científico publicado en 2018

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity

artículo científico publicado en 2012

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

artículo científico publicado en 2017