Lista de obras -

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer

artículo científico publicado en 2017

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

artículo científico publicado en 2013

A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1.

artículo científico publicado en 2015

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

artículo científico publicado en 2002

Abstract A28: Challenging new epigenetic vulnerabilities in human metastatic melanoma PDXs

Acetylation: a novel link between double-strand break repair and autophagy

artículo científico publicado en 2012

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

scientific article published on 23 January 2017

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide

artículo científico publicado en 2002

Assessment of histone acetylation levels in relation to cell cycle phase.

artículo científico publicado en 2008

Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

artículo científico publicado en 2019

BLUEPRINT to decode the epigenetic signature written in blood.

artículo científico publicado en 2012

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

artículo científico publicado en 2014

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

artículo científico publicado en 2010

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

artículo científico publicado en 2009

Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

artículo científico publicado en 2014

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

artículo científico publicado en 2012

Chromatin immunoprecipitation and high-throughput sequencing from paraffin-embedded pathology tissue

artículo científico publicado en 2011

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

artículo científico publicado en 2014

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

artículo científico publicado en 2019

Comparing apples with oranges: Studying LSD1 inhibitors in cellular assays

scientific article published on 08 July 2019

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

artículo científico publicado en 2017

Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

artículo científico publicado en 2018

DNA binding modes of leukemia oncoproteins.

artículo científico publicado en 2016

Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force

artículo científico publicado en 2007

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

artículo científico publicado en 2015

Differentiation response of acute promyelocytic leukemia cells and PML/RARa leukemogenic activity studies by real-time RT-PCR.

artículo científico publicado en 2005

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models

scientific article published on 13 February 2020

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

artículo científico publicado en 2015

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

artículo científico publicado en 2011

Dual inhibition of mTOR pathway and VEGF signalling in neuroendocrine neoplasms: from bench to bedside.

artículo científico

Dual modulation of MCL-1 and mTOR determines the response to sunitinib

artículo científico publicado en 2016

Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors ⬇️

artículo científico publicado el 4 de agosto de 1995

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

article

Entinostat for the treatment of breast cancer.

artículo científico

Epigenetic alterations in acute myeloid leukemias

artículo científico publicado en 2014

Epigenetic therapies in haematological malignancies: searching for true targets

artículo científico publicado en 2009

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology

artículo científico publicado en 2018

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.

artículo científico publicado en 2018

Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data ⬇️

artículo científico publicado el 6 de octubre de 2011

Fragment-based identification of Hsp90 inhibitors

artículo científico publicado en 2009

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

artículo científico publicado en 2017

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.

artículo científico publicado en 2013

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

artículo científico publicado en 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

scientific article published on 28 March 2014

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

artículo científico publicado en 2011

Histone Modification Therapy of Cancer

artículo científico publicado el 1 de enero de 2010

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer

artículo científico publicado en 2009

Histone deacetylases and epigenetic therapies of hematological malignancies

artículo científico publicado en 2010

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

artículo científico publicado en 2002

Identification of a Novel cis-Element Required for the Constitutive Activity and Osmotic Response of the Rat Aldose Reductase Promoter ⬇️

artículo científico publicado el 19 de diciembre de 1997

Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer

scientific article published on 30 March 2019

Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells

artículo científico publicado en 2007

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

artículo científico publicado en 2004

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

artículo científico publicado en 2016

In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue

scientific article published on 01 August 2002

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

artículo científico publicado en 2004

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

artículo científico publicado en 2011

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression

artículo científico publicado en 2003

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

artículo científico publicado en 2008

MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function

artículo científico publicado en 2005

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.

artículo científico publicado en 2016

Mechanisms of selective anticancer action of histone deacetylase inhibitors

artículo científico publicado en 2005

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

artículo científico publicado en 2002

Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy

article

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

artículo científico publicado en 2013

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation

artículo científico publicado en 2009

New method to detect histone acetylation levels by flow cytometry

artículo científico publicado en 2005

Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? ⬇️

artículo científico publicado el 23 de febrero de 2011

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model

artículo científico publicado en 2017

Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

artículo científico publicado en 2007

PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples.

artículo científico publicado en 2014

PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

artículo científico publicado en 2002

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

artículo científico publicado en 2017

Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples

artículo científico publicado en 2015

Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples.

artículo científico publicado en 2010

Pharmacokinetic drug evaluation of ribociclib for the treatment of metastatic, hormone-positive breast cancer

artículo científico publicado en 2017

Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside

artículo científico publicado en 2019

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

artículo científico publicado en 2007

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

artículo científico publicado en 2014

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts

article

Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells

Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.

artículo científico publicado en 2014

Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein

artículo científico publicado en 2006

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

artículo científico publicado en 2015

Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties

scientific article published on December 2003

Retinoid-Induced Chromatin Structure Alterations in the Retinoic Acid Receptor β2 Promoter ⬇️

artículo científico publicado el 1 de noviembre de 1997

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

artículo científico publicado en 2007

SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells

artículo científico publicado en 2010

Semantic and Geographical Analysis of COVID-19 Trials Reveals a Fragmented Clinical Research Landscape Likely to Impair Informativeness

artículo científico publicado en 2020

Semantic and geographical analysis of Covid-19 trials reveals a fragmented clinical research landscape likely to impair informativeness.

artículo científico publicado en 2020

Shiftworking keeps locked-down lab on track

scientific article published on 01 April 2020

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity

artículo científico publicado en 2012

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

artículo científico publicado en 2018

Synthesis and biological characterization of amidopropenyl hydroxamates as HDAC inhibitors

artículo científico publicado en 2010

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors

artículo científico publicado en 2013

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors

artículo científico publicado en 2010

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A

artículo científico publicado en 2014

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors

artículo científico publicado en 2015

Targeting protein inactivation through an oligomerization chain reaction

artículo científico publicado en 2002

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation

artículo científico publicado en 2020

The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia

artículo científico publicado en 2012

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

artículo científico publicado en 2007

The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome

artículo científico publicado en 2004

The methyl-CpG binding protein MBD1 is required for PML-RARalpha function

artículo científico publicado en 2006

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

artículo científico publicado en 2009

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

artículo científico publicado en 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

artículo científico publicado en 2017

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation

artículo científico publicado en 2020

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

artículo científico publicado en 2017

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition

scientific article published on 19 September 2019

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

artículo científico publicado en 2016

p66Shc-generated oxidative signal promotes fat accumulation

artículo científico publicado en 2008

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1.

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Abstract A28: Challenging new epigenetic vulnerabilities in human metastatic melanoma PDXs

Acetylation: a novel link between double-strand break repair and autophagy

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide

Assessment of histone acetylation levels in relation to cell cycle phase.

Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

BLUEPRINT to decode the epigenetic signature written in blood.

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

Chromatin immunoprecipitation and high-throughput sequencing from paraffin-embedded pathology tissue

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Comparing apples with oranges: Studying LSD1 inhibitors in cellular assays

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

DNA binding modes of leukemia oncoproteins.

Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Differentiation response of acute promyelocytic leukemia cells and PML/RARa leukemogenic activity studies by real-time RT-PCR.

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

Dual inhibition of mTOR pathway and VEGF signalling in neuroendocrine neoplasms: from bench to bedside.

Dual modulation of MCL-1 and mTOR determines the response to sunitinib

Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors ⬇️

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

Entinostat for the treatment of breast cancer.

Epigenetic alterations in acute myeloid leukemias

Epigenetic therapies in haematological malignancies: searching for true targets

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.

Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data ⬇️

Fragment-based identification of Hsp90 inhibitors

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Guidelines for the use and interpretation of assays for monitoring autophagy

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

Histone Modification Therapy of Cancer

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer

Histone deacetylases and epigenetic therapies of hematological malignancies

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

Identification of a Novel cis-Element Required for the Constitutive Activity and Osmotic Response of the Rat Aldose Reductase Promoter ⬇️

Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer

Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.

Mechanisms of selective anticancer action of histone deacetylase inhibitors

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation

New method to detect histone acetylation levels by flow cytometry

Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? ⬇️

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model

Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples.

PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples

Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples.

Pharmacokinetic drug evaluation of ribociclib for the treatment of metastatic, hormone-positive breast cancer

Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside