Lista de obras -

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids

artículo científico publicado en 2007

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

artículo científico publicado en 2011

Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II

scientific article published on 27 November 2001

Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes

artículo científico publicado en 2006

Carbon and amide detect backbone assignment methods of a novel repeat protein from the staphylocoagulase in S. aureus

artículo científico publicado en 2017

Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation

artículo científico publicado en 2008

Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains

artículo científico publicado en 2016

Coupling of conformational and proteolytic activation in the kinetic mechanism of plasminogen activation by streptokinase

artículo científico publicado en 2004

Development of coagulation factor probes for the identification of procoagulant circulating tumor cells

artículo científico publicado en 2012

Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein

artículo científico publicado en 2012

Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin

artículo científico publicado en 2003

Efficacy, tolerability and safety of propiverine hydrochloride in comparison to oxybutynin in children with urge incontinence due to overactive bladder: Results of a multicentre observational cohort study

artículo científico publicado en 2009

Engineering streptokinase for generation of active site-labeled plasminogen analogs ⬇️

artículo científico publicado el 23 de abril de 2011

Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX.

artículo científico publicado en 2005

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation

artículo científico publicado en 2007

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

artículo científico publicado en 2006

Full time course kinetics of the streptokinase-plasminogen activation pathway

scientific article published on 22 August 2013

Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

artículo científico publicado en 2003

In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model

artículo científico publicado en 2015

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

artículo científico publicado en 2011

Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

artículo científico publicado en 2010

Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes

artículo científico publicado en 2011

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions

artículo científico publicado en 2006

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.

scientific article published on 27 May 2009

Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study

artículo científico publicado en 2008

Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function

scientific article published on 27 March 2019

Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism

artículo científico publicado en 2014

Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation

artículo científico publicado en 2008

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

artículo científico publicado en 2005

Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase

artículo científico publicado en 2004

Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

artículo científico publicado en 2007

Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin

artículo científico publicado en 2003

Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin

artículo científico publicado en 2004

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

artículo científico publicado en 2007

Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.

artículo científico publicado en 2003

Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation

artículo científico publicado en 2010

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

artículo científico publicado en 2010

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

artículo científico publicado en 2003

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation

artículo científico publicado en 2005

Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction

artículo científico publicado en 2011

The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II

artículo científico publicado en 2003

The role of thrombin exosites I and II in the activation of human coagulation factor V.

artículo científico publicado en 2007

Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin

scholarly article

Lista de obras de

A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II

Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes

Carbon and amide detect backbone assignment methods of a novel repeat protein from the staphylocoagulase in S. aureus

Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation

Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains

Coupling of conformational and proteolytic activation in the kinetic mechanism of plasminogen activation by streptokinase

Development of coagulation factor probes for the identification of procoagulant circulating tumor cells

Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein

Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin

Efficacy, tolerability and safety of propiverine hydrochloride in comparison to oxybutynin in children with urge incontinence due to overactive bladder: Results of a multicentre observational cohort study

Engineering streptokinase for generation of active site-labeled plasminogen analogs ⬇️

Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX.

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes

Full time course kinetics of the streptokinase-plasminogen activation pathway

Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation

Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.

Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study

Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function

Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism

Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase

Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin

Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.

Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation

Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction

The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin cofactor II

The role of thrombin exosites I and II in the activation of human coagulation factor V.

Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin