Filtros de búsqueda

Lista de obras de

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells

artículo científico publicado en 2007

14-3-3 proteins as potential therapeutic targets

artículo científico publicado en 2011

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

artículo científico publicado en 2008

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

artículo científico publicado en 2015

A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer

artículo científico publicado en 2015

A better angel of our nature: Hanna Michel "Jean" Khoury, MD (April 24, 1967-May 22, 2017).

artículo científico publicado en 2017

A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides

artículo científico publicado en 2008

A phase II study of Lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck.

artículo científico publicado en 2009

A systematic analysis of efficacy of second-line chemotherapy in sensitive and refractory small-cell lung cancer

artículo científico publicado en 2012

A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors

artículo científico publicado en 2013

Aberrant promoter methylation of caveolin-1 is associated with favorable response to taxane-platinum combination chemotherapy in advanced NSCLC

artículo científico publicado en 2014

Acetylated tubulin (AT) as a prognostic marker in squamous cell carcinoma of the head and neck

artículo científico publicado en 2013

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

artículo científico publicado en 2005

Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.

artículo científico publicado en 2005

Adenoid cystic carcinoma of the head and neck: Incidence and survival trends based on 1973-2007 Surveillance, Epidemiology, and End Results data.

artículo científico publicado en 2012

Advances in chemoprevention of head and neck cancer

artículo científico publicado en 2004

Altered glutamine metabolism and therapeutic opportunities for lung cancer

artículo científico publicado en 2013

Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact

artículo científico publicado en 2010

Assessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells

artículo científico publicado en 2007

Association of Cytoplasmic CXCR4 With Loss of Epithelial Marker and Activation of ERK1/2 and AKT Signaling Pathways in Non-Small-Cell Lung Cancer

artículo científico

Atypical carcinoid tumor of the lung: a surveillance, epidemiology, and end results database analysis

artículo científico publicado en 2015

Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy

artículo científico publicado en 2011

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

artículo científico publicado en 2013

Bevacizumab in Combination with Taxane versus Non-Taxane Containing Regimens for Advanced/Metastatic Nonsquamous Non-Small-Cell Lung Cancer: A Systematic Review

artículo científico publicado en 2015

CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.

artículo científico publicado en 2008

CCAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of tumor necrosis factor-related apoptosis-inducing

artículo científico publicado en 2007

CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.

artículo científico publicado en 2013

Cables1 complex couples survival signaling to the cell death machinery

artículo científico publicado en 2014

California dreaming.

artículo científico publicado en 2017

Can statins pass the aspirin litmus test in cancer?

artículo científico publicado en 2007

Can we achieve an 80% screening rate for colorectal cancer by 2018 in the United States?

artículo científico publicado en 2015

Cancer prevention with natural compounds

artículo científico publicado en 2010

Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism

artículo científico publicado en 2009

Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3.

artículo científico

Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells.

artículo científico publicado en 2006

Characteristics and Outcomes of Patients With Metastatic KRAS-Mutant Lung Adenocarcinomas: The Lung Cancer Mutation Consortium Experience

scientific article published on 05 February 2019

Chemoprevention in lung cancer

artículo científico publicado en 2004

Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.

artículo científico publicado en 2013

Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study

artículo científico publicado en 2013

Chemoprevention of respiratory tract cancer ⬇️

artículo científico publicado el 1 de junio de 1997

Chemoprevention strategies for patients with lung cancer in the context of screening

artículo científico publicado en 2005

Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer.

artículo científico publicado en 2014

Clinical efficacy of targeted biologic agents as second-line therapy of advanced thyroid cancer

artículo científico publicado en 2013

Clinical outcomes in elderly patients with human papillomavirus-positive squamous cell carcinoma of the oropharynx treated with definitive chemoradiation therapy

artículo científico publicado en 2015

Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer

artículo científico publicado en 2002

Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma

artículo científico publicado en 2014

Combination of erlotinib and EGCG induces apoptosis of head and neck cancers through posttranscriptional regulation of Bim and Bcl-2.

artículo científico publicado en 2015

Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.

artículo científico publicado en 2015

Comparison of Concurrent Use of Thoracic Radiation With Either Carboplatin-Paclitaxel or Cisplatin-Etoposide for Patients With Stage III Non-Small-Cell Lung Cancer: A Systematic Review

artículo científico publicado en 2016

Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature

artículo científico publicado en 2017

Concurrent chemoradiotherapy with weekly versus triweekly cisplatin in locally advanced squamous cell carcinoma of the head and neck: Comparative analysis

scientific article published on 05 March 2019

Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: a retrospective single-institution analysis

artículo científico publicado en 2009

Concurrent therapy with taxane versus non-taxane containing regimens in locally advanced squamous cell carcinomas of the head and neck (SCCHN): a systematic review

artículo científico publicado en 2014

Correction: Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling

artículo científico publicado en 2020

Correction: Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IκBα degradation

artículo científico publicado en 2020

Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer

artículo científico publicado en 2002

Corrigendum to "FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway" [Canc. Lett. 363 (2015) 166-175]

artículo científico publicado en 2020

Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation

artículo científico publicado en 2008

Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.

artículo científico publicado en 2004

Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

artículo científico publicado en 2005

Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

scientific article published on 02 May 2006

Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

artículo científico publicado en 2005

Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles

artículo científico publicado en 2011

Development and testing of a tool to assess patient preferences for phase I clinical trial participation

artículo científico publicado en 2014

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

artículo científico publicado en 2010

Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells

artículo científico publicado en 2009

Dose escalation with over-dose and under-dose controls in Phase I/II clinical trials

artículo científico publicado en 2015

Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation

artículo científico publicado en 2007

Durable long-term remission with chemotherapy alone for stage II to IV laryngeal cancer.

artículo científico publicado en 2009

Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways.

artículo científico publicado en 2006

ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1

artículo científico publicado en 2010

Early detection of lung cancer in China: The immediate imperative

artículo científico publicado en 2015

Editor's Note: Identification of Insulin-Like Growth Factor Binding Protein-3 as a Farnesyl Transferase Inhibitor SCH66336-Induced Negative Regulator of Angiogenesis in Head and Neck Squamous Cell Carcinoma

artículo científico publicado en 2019

Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells

artículo científico

Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer

artículo científico publicado en 2012

Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53

artículo científico publicado en 2010

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

artículo científico publicado en 2008

Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells

artículo científico publicado en 2015

Escalation with overdose control using all toxicities and time to event toxicity data in cancer Phase I clinical trials.

artículo científico publicado en 2014

Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models

Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer

artículo científico publicado en 2004

FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway

artículo científico publicado en 2015

Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies

artículo científico publicado en 2011

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

artículo científico publicado en 2007

Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells

artículo científico publicado en 2005

Farnesyltransferase inhibitors reverse taxane resistance

artículo científico publicado en 2006

Five more years! Not everything changes.

artículo científico publicado en 2017

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth ⬇️

artículo científico publicado en 2015

Gender and ethnic disparities in incidence and survival of squamous cell carcinoma of the oral tongue, base of tongue, and tonsils: a surveillance, epidemiology and end results program-based analysis

artículo científico publicado en 2011

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

artículo científico publicado en 2015

HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium.

artículo científico publicado en 2017

HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models

artículo científico publicado en 2016

HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers

artículo científico publicado en 2017

HPV positive squamous cell carcinoma of the oropharynx. Are we observing an unusual pattern of metastases?

artículo científico publicado en 2012

Head and neck cancer chemoprevention gets a shot in the arm

artículo científico publicado en 2008

Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma

artículo científico publicado en 2015

Human immunodeficiency virus-associated lung cancer in the era of highly active antiretroviral therapy

artículo científico publicado en 2011

Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma

artículo científico publicado en 2006

Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells

artículo científico publicado en 2003

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

scientific article published on 23 July 2015

Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial

artículo científico publicado en 2013

Induction of cell cycle arrest and apoptosis by a combined treatment with 13-cis-retinoic acid, interferon-alpha2a, and alpha-tocopherol in squamous cell carcinoma of the head and neck

artículo científico publicado en 2007

Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer

scientific article published on 23 June 2018

Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer

artículo científico publicado en 2013

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

artículo científico publicado en 2007

Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression

artículo científico publicado en 2008

Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade

artículo científico publicado en 2013

Interactive Software "Isotonic Design using Normalized Equivalent Toxicity Score (ID-NETS©TM)" for Cancer Phase I Clinical Trials

artículo científico publicado en 2013

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

artículo científico publicado en 2008

LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins

artículo científico publicado en 2008

LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

artículo científico publicado en 2015

Laryngeal tumor volume as a predictor for thyroid cartilage penetration

artículo científico

Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells.

artículo científico publicado en 2007

Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer.

artículo científico publicado en 2014

Longitudinal study of smoking patterns in relation to the development of smoking-related secondary primary tumors in patients with upper aerodigestive tract malignancies

artículo científico publicado en 2004

Lung Adenocarcinoma Staging Using the 2011 IASLC/ATS/ERS Classification: A Pooled Analysis of Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma

artículo científico publicado en 2016

Lung cancer in China: The new frontier?

artículo científico publicado en 2015

Lung cancer in the elderly: what's age got to do with it?

artículo científico publicado el 15 de noviembre de 2010

Lung cancer with translocation in the anaplastic lymphoma kinase gene: a disease within a disease.

artículo científico publicado en 2012

Lung cancer: New biological insights and recent therapeutic advances

artículo científico publicado en 2011

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

artículo científico publicado en 2014

MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

scientific article published on 19 July 2018

Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth

artículo científico publicado en 2014

Mannitol to prevent cisplatin-induced nephrotoxicity in patients with squamous cell cancer of the head and neck (SCCHN) receiving concurrent therapy.

artículo científico

Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer.

artículo científico publicado en 2004

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

artículo científico publicado en 2015

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer ⬇️

artículo científico publicado el 5 de septiembre de 2010

Modernizing Eligibility Criteria for Molecularly Driven Trials.

artículo científico publicado en 2015

Monitoring 14-3-3 protein interactions with a homogeneous fluorescence polarization assay

artículo científico publicado en 2006

Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax

artículo científico publicado en 2010

Moving toward bioadjuvant approaches to head and neck cancer prevention

artículo científico publicado en 2007

NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop

artículo científico publicado en 2011

National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer

artículo científico publicado en 2016

Necitumumab in Metastatic Squamous Cell Lung Cancer: Establishing a Value-Based Cost

artículo científico publicado en 2015

New paradigm in dose-finding trials: patient-specific dosing and beyond phase I

scientific article published on 01 August 2005

Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer

artículo científico publicado en 2013

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling

artículo científico publicado en 2012

Optimizing systemic therapy in squamous cell carcinoma of the head and neck with a focus on targeted agents

scientific article published on May 2009

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy

scientific article published on 08 December 2008

PI3 kinase, mTOR, and AKT pathways

artículo científico publicado en 2009

PPARgamma ligands enhance TRAIL-induced apoptosis through DR5 upregulation and c-FLIP downregulation in human lung cancer cells

scientific article published on 01 January 2007

Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

artículo científico publicado en 2016

Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers.

artículo científico publicado en 2011

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

artículo científico publicado en 2009

Perspectives for cancer prevention with natural compounds

artículo científico publicado en 2009

Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck

artículo científico publicado en 2014

Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer.

artículo científico publicado en 2010

Phase 1 safety and pharmacodynamic study of lenalidomide combined with everolimus in patients with advanced solid malignancies with efficacy signal in adenoid cystic carcinoma

scientific article published on 24 July 2020

Phase 1B Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck

scientific article published on 17 September 2020

Phase 2 bioadjuvant study of interferon alfa-2a, isotretinoin, and vitamin E in locally advanced squamous cell carcinoma of the head and neck: long-term follow-up

artículo científico publicado en 2005

Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers.

artículo científico publicado en 2003

Phase I study of the farnesyltransferase inhibitor BMS-214662 given weekly in patients with solid tumors

artículo científico publicado en 2005

Phase I trial of weekly topotecan and gemcitabine in patients with solid tumors

artículo científico publicado en 2009

Phase II Trial of docetaxel and cisplatin combination chemotherapy in patients with squamous cell carcinoma of the head and neck

artículo científico publicado en 2002

Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer

artículo científico publicado en 2002

Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer.

artículo científico publicado en 2013

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status

artículo científico publicado en 2017

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

artículo científico publicado en 2012

Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues

artículo científico publicado en 2009

Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond

artículo científico publicado en 2011

Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.

artículo científico publicado en 2014

Postoperative radiotherapy is associated with better survival in non-small cell lung cancer with involved N2 lymph nodes: results of an analysis of the National Cancer Data Base

artículo científico publicado en 2015

Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers

artículo científico publicado en 2015

Predictors and outcomes of venous thromboembolism in hospitalized lung cancer patients: A Nationwide Inpatient Sample database analysis

artículo científico publicado en 2015

Preoperative therapy for early-stage NSCLC: opportunities and challenges.

artículo científico publicado en 2009

Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth

artículo científico publicado en 2017

Prevention of head and neck cancer: current status and future prospects

artículo científico publicado en 2004

Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs

artículo científico publicado en 2014

Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers

artículo científico publicado en 2004

Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma

artículo científico publicado en 2013

Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

artículo científico publicado en 2010

Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis

artículo científico publicado en 2004

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation

artículo científico publicado en 2013

Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.

artículo científico publicado en 2010

Pulmonary Sarcomatoid Carcinoma: An Analysis of the National Cancer Data Base

artículo científico publicado en 2016

Quantum dot-based quantification revealed differences in subcellular localization of EGFR and E-cadherin between EGFR-TKI sensitive and insensitive cancer cells

artículo científico publicado en 2009

Racial disparities in squamous cell carcinoma of the oral tongue among women: a SEER data analysis

artículo científico publicado en 2015

Randomized phase III trial of low-dose isotretinoin for prevention of second primary tumors in stage I and II head and neck cancer patients.

artículo científico publicado en 2006

Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597.

artículo científico publicado en 2013

Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells

artículo científico publicado en 2011

Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression

artículo científico publicado en 2015

Real-world effectiveness of systemic agents approved for advanced non-small cell lung cancer: a SEER-Medicare analysis.

artículo científico publicado en 2013

Replicative oncolytic adenoviruses in multimodal cancer regimens

artículo científico publicado en 2003

Research biopsies in phase I studies: views and perspectives of participants and investigators

artículo científico publicado en 2012

Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression

artículo científico publicado en 2011

Retinoids in lung cancer: friend, foe, or fellow traveler?

artículo científico publicado en 2004

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

artículo científico publicado en 2015

Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma

artículo científico publicado en 2013

Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium

artículo científico publicado en 2015

Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States).

artículo científico publicado en 2003

Selective Serotonin Reuptake Inhibitor-induced Rhabdomyolysis Associated with Irinotecan

artículo científico publicado el 1 de octubre de 2003

Single agent maintenance therapy for advanced stage non-small cell lung cancer: a meta-analysis

artículo científico publicado en 2012

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

artículo científico publicado en 2015

Small-molecule Bax agonists for cancer therapy

artículo científico publicado en 2014

Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer

artículo científico publicado en 2013

Statistical learning methods as a preprocessing step for survival analysis: evaluation of concept using lung cancer data

artículo científico publicado en 2011

Survival Outcomes With Thoracic Radiotherapy in Extensive-Stage Small-Cell Lung Cancer: A Propensity Score-Matched Analysis of the National Cancer Database

scientific article published on 18 June 2019

Survival analysis of patients with stage I non-small-cell lung cancer using clinical and DNA repair pathway expression variables

artículo científico publicado en 2012

Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erlotinib and epigallocatechin-3-gallate: the role of p53-dependent inhibition of nuclear factor-kappaB.

artículo científico publicado en 2009

Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor

artículo científico publicado en 2008

Targeted therapies in metastatic esophageal cancer: advances over the past decade

artículo científico publicado en 2014

Targeting angiogenesis in head and neck cancer

artículo científico publicado en 2007

Targeting mTOR signaling for lung cancer therapy

artículo científico publicado en 2006

Targeting the PI3K/AKT/mTOR pathway: biomarkers of success and tribulation

artículo científico

Targeting the epidermal growth factor receptor. Trials in head and neck and lung cancer.

artículo científico publicado en 2006

Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth

artículo científico publicado en 2016

The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition

artículo científico publicado en 2015

The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.

artículo científico publicado en 2018

The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis

artículo científico publicado en 2013

The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells

artículo científico publicado en 2011

The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis

artículo científico publicado en 2013

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

artículo científico publicado en 2017

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

artículo científico publicado en 2007

The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo

artículo científico publicado en 2011

The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo.

artículo científico publicado en 2012

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

artículo científico publicado en 2005

The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation

artículo científico publicado en 2010

The farnesyltransferase inhibitor Lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of Akt.

artículo científico publicado en 2004

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells

artículo científico publicado en 2007

The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells.

artículo científico publicado en 2007

The fork in the road: Waun Ki Hong, John Mendelsohn, and the reinvigoration of The University of Texas MD Anderson Cancer Center

artículo científico publicado en 2019

The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R.

artículo científico publicado en 2009

The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.

artículo científico publicado en 2008

The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer

artículo científico publicado en 2014

The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition

artículo científico publicado en 2012

The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis

artículo científico publicado en 2013

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells

artículo científico publicado en 2007

The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 1: Mechanisms of action, role of biomarkers and preclinical applications

artículo científico publicado en 2004

The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 2: Clinical studies and economic analyses

artículo científico publicado en 2005

The role of the taxanes in the treatment of older patients with advanced stage non-small cell lung cancer

scientific article published on 02 April 2009

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase

artículo científico publicado en 2005

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

artículo científico publicado en 2008

Therapeutic misconception, misestimation, and optimism in participants enrolled in phase 1 trials.

artículo científico publicado en 2012

Through the looking glass: the evolution of erythropoiesis-stimulating agent use.

artículo científico publicado en 2010

Time to divest from tobacco-funded research

artículo científico publicado en 2015

Translation of innovative designs into phase I trials

artículo científico publicado en 2007

Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial

artículo científico publicado en 2003

Trends, predictors, and impact of systemic chemotherapy in small cell lung cancer patients between 1985 and 2005.

artículo científico publicado en 2015

Trimodality Therapy in the Treatment of Stage III N2-Positive Non-Small Cell Lung Cancer: A National Cancer Database Analysis

artículo científico publicado en 2020

Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model

artículo científico publicado en 2005

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

artículo científico publicado en 2014

Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.

artículo científico publicado en 2014

Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

artículo científico publicado en 2014

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

artículo científico publicado en 2013

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

artículo científico publicado en 2009

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

artículo científico publicado en 2011

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

artículo científico publicado en 2011

Use of replicating oncolytic adenoviruses in combination therapy for cancer

artículo científico publicado en 2004

What is the role of maintenance therapy in the treatment of non-small cell lung cancer?

artículo científico publicado en 2010

YAP1 Expression in Small Cell Lung Cancer Defines a Distinct Subtype with T-cell Inflamed Phenotype

scientific article published on 25 November 2020

c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

artículo científico publicado en 2010

c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.

artículo científico publicado en 2007

c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

artículo científico publicado en 2010

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

artículo científico publicado en 2004

c-Myc suppression of DNA double-strand break repair

artículo científico publicado en 2012

caGrid-Enabled caBIG Silver Level Compatible Head and Neck Cancer Tissue Database System

artículo científico publicado en 2010

hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer

scientific article published on 01 September 2002

mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation

artículo científico publicado en 2015

mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis

artículo científico publicado en 2013

p53 upregulates death receptor 4 expression through an intronic p53 binding site

artículo científico publicado en 2004

p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms

artículo científico publicado en 2013

p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells

artículo científico publicado en 2010

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda