Filtros de búsqueda

Lista de obras de

A Comparison of the Solvation Properties of 2-Nitrophenyloctyl Ether, Nitrobenzene, andn-Octanol as Assessed by Ion Transfer Experiments

A fast screening strategy for characterizing peptide delivery by transdermal iontophoresis

artículo científico publicado en 2009

A simple model to predict blood-brain barrier permeation from 3D molecular fields

artículo científico publicado en 2002

A study of interlaboratory influence on column evaluation

artículo científico publicado en 2005

Advances in LC platforms for drug discovery

artículo científico publicado en 2010

Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System

Alkaloids from psychotria target sirtuins: in silico and in vitro interaction studies

artículo científico publicado en 2014

An Effective Tool for Column Evaluation in the Analysis of Basic Compounds

Analysis of basic compounds at high pH values by reversed-phase liquid chromatography

artículo científico publicado en 2004

Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution

artículo científico publicado en 2009

Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.

artículo científico publicado en 2008

Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.

artículo científico publicado en 2008

Antioxidant phenylethanoid glycosides and a neolignan from Jacaranda caucana

artículo científico publicado en 2009

Aurones as histone deacetylase inhibitors: identification of key features

artículo científico publicado en 2014

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

artículo científico publicado en 2011

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

artículo científico publicado en 2009

Characterization of chromatographic supports for the analysis of basic compounds

Charge and Delocalisation Effects on the Lipophilicity of Protonable Drugs

Comparison of various silica-based monoliths for the analysis of large biomolecules

artículo científico publicado en 2013

Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals

artículo científico publicado en 2014

Conformational analysis of α-methoxyketones. A photoelectron spectroscopic investigation of 3-methoxybicyclo[2.2.1]heptan-2-ones

Covalent modifications of antitetanus F(ab')2 fragments with natural and synthetic polyamines and their effects on the antibody endocytosis in cultured HL60 cells

artículo científico publicado en 2008

Cyclic voltammetry of highly hydrophilic ions at a supported liquid membrane

article published in 2002

Cycloadditions of enones

D-LogP: an alignment-free 3D description of local lipophilicity for QSAR studies

scientific article published on 01 January 2004

Determination of alkane/water partition coefficients of polar compounds using hydrophilic interaction chromatography ⬇️

artículo científico publicado el 19 de octubre de 2012

Determination of pKa values by capillary zone electrophoresis with a dynamic coating procedure

artículo científico publicado en 2005

Development of a two-step screening ESI-TOF-MS method for rapid determination of significant stress-induced metabolome modifications in plant leaf extracts: The wound response in Arabidopsis thaliana as a case study

article

Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed

artículo científico publicado en 2006

Diastereoselective radical alkylations of alkyl aryl sulfoxides

artículo científico publicado en 1996

Drug-protein binding: a critical review of analytical tools

artículo científico publicado en 2010

Edaravone derivatives containing NO-donor functions

artículo científico publicado en 2009

Effects of Charge and Intramolecular Structure on the Lipophilicity of Nitrophenols

artículo científico publicado en 1999

Enantiomeric resolution of sulfoxides on a DACH-DNB chiral stationary phase: A quantitative structure-enantioselective retention relationship (QSERR) study

article by Cosimo Altomare et al published 1993 in Chirality

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

artículo científico publicado en 2010

Establishment of a Human 3D Tissue-Based Assay for Upper Respiratory Tract Absorption

Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling.

artículo científico publicado en 2002

Fast log P determination by ultra-high-pressure liquid chromatography coupled with UV and mass spectrometry detections

artículo científico publicado en 2009

Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle

artículo científico publicado en 2007

Fluoride curcumin derivatives: new mitochondrial uncoupling agents

artículo científico publicado en 2004

Global analytical strategy to measure drug-plasma protein interactions: from high-throughput to in-depth analysis

artículo científico publicado en 2013

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

artículo científico publicado en 2013

HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurements

artículo científico publicado en 2016

High performance affinity chromatography (HPAC) as a high-throughput screening tool in drug discovery to study drug-plasma protein interactions

artículo científico publicado en 2012

High resolution ultra high pressure liquid chromatography-time-of-flight mass spectrometry dereplication strategy for the metabolite profiling of Brazilian Lippia species

artículo científico publicado en 2012

High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media

artículo científico publicado en 2007

High-throughput log P determination by MEEKC coupled with UV and MS detections.

artículo científico publicado en 2010

High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists

artículo científico publicado en 2008

How the flexibility of human histone deacetylases influences ligand binding: an overview

artículo científico publicado en 2015

How to increase the safety and efficacy of compounds against neurodegeneration? A multifunctional approach.

artículo científico publicado en 2012

Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening

artículo científico publicado en 2005

Human sirtuins: Structures and flexibility

artículo científico publicado en 2016

Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors

artículo científico publicado en 2004

Immobilized artificial membrane HPLC in drug research.

artículo científico publicado en 2003

Immobilized artificial membrane liquid chromatography: proposed guidelines for technical optimization of retention measurements

artículo científico publicado en 2002

Immobilized pH gradient gel cell to study the pH dependence of drug lipophilicity

artículo científico publicado en 2006

Impact of species-dependent differences on screening, design, and development of MAO B inhibitors

artículo científico publicado en 2006

Improvement of a capillary electrophoresis/frontal analysis (CE/FA) method for determining binding constants: discussion on relevant parameters

artículo científico publicado en 2010

In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities

artículo científico publicado en 2007

In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: thin layer chromatography versus microplate methods

artículo científico publicado en 2007

Indole alkaloids and semisynthetic indole derivatives as multifunctional scaffolds aiming the inhibition of enzymes related to neurodegenerative diseases--a focus on Psychotria L. Genus

artículo científico publicado en 2014

Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors

artículo científico publicado en 2012

Inhibition screening method of microsomal UGTs using the cocktail approach

artículo científico publicado en 2015

Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine

Ionic Partition Diagrams: A Potential−pH Representation

scientific article published in 1996

Isolation and biological activity of compounds from Garcinia preussii

artículo científico publicado en 2014

Isolation and quantification by high-performance liquid chromatography-ion-trap mass spectrometry of androgen sulfoconjugates in human urine.

artículo científico publicado en 2008

Large, chemically diverse dataset of logP measurements for benchmarking studies

artículo científico publicado en 2012

Lipophilicity Profiles of Ampholytes

artículo científico publicado en 1997

Lipophilicity and solvation of anionic drugs

artículo científico publicado en 2002

Lipophilicity determination of highly lipophilic compounds by liquid chromatography

artículo científico publicado en 2009

Lipophilicity of basic drugs measured by hydrophilic interaction chromatography

scientific article published on 01 May 2009

Liposome/water lipophilicity: methods, information content, and pharmaceutical applications

artículo científico publicado en 2004

MLP Tools: a PyMOL plugin for using the molecular lipophilicity potential in computer-aided drug design

artículo científico publicado en 2014

Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry

article

Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research ⬇️

artículo científico publicado el 26 de junio de 2013

Modeling the met form of human tyrosinase: a refined and hydrated pocket for antagonist design

artículo científico publicado en 2014

Modification of a PAMPA model to predict passive gastrointestinal absorption and plasma protein binding

artículo científico publicado en 2015

Molecular Docking Using the Molecular Lipophilicity Potential as Hydrophobic Descriptor: Impact on GOLD Docking Performance ⬇️

artículo científico publicado el 21 de abril de 2012

Molecular dynamics of zinc-finger ubiquitin binding domains: a comparative study of histone deacetylase 6 and ubiquitin-specific protease 5.

artículo científico publicado en 2015

Molecular electrocatalysis for oxygen reduction by cobalt porphyrins adsorbed at liquid/liquid interfaces

artículo científico publicado en 2010

Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol

artículo científico publicado en 2002

Molecular-Dynamics and NMR Investigation of the Property Space of the Zwitterionic Antihistamine Cetirizine

Monoamine oxidase inhibition by Rhodiola rosea L. roots

artículo científico publicado en 2009

Multivariate data analysis of rapid LC-TOF/MS experiments from Arabidopsis thaliana stressed by wounding

article

NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

scientific article published on 03 March 2007

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization

artículo científico publicado en 2007

Natural and Synthetic Xanthones as Monoamine Oxidase Inhibitors: Biological Assay and 3D-QSAR

scholarly article by Carmela Gnerre et al published 21 March 2001 in Helvetica Chimica Acta

Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies

artículo científico publicado en 2002

Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols

artículo científico publicado en 2014

Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme

artículo científico publicado en 2012

Normal phase HPLC-based activity profiling of non-polar crude plant extracts - acetylcholinesterase inhibiting guttiferones from Montrouziera cauliflora as a case study

artículo científico publicado en 2016

Novel RPLC stationary phases for lipophilicity measurement: solvatochromic analysis of retention mechanisms for neutral and basic compounds

artículo científico publicado en 2005

Novel screening assay for antioxidant protection against peroxyl radical-induced loss of protein function

scientific article published on 01 November 2007

Numerical simulation of two-phase partition chromatography in microchannels for moderated logP measurements

artículo científico publicado en 2005

Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase

artículo científico publicado en 2009

Optical biosensor analysis in studying new synthesized bicalutamide analogs binding to androgen receptor

artículo científico publicado en 2014

Optimized liquid chromatography–mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance

article

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability

scientific article published on 01 June 2006

Partition coefficients of ionizable compounds in o-nitrophenyl octyl ether/water measured by the potentiometric method

artículo científico publicado en 2003

Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical Study

artículo científico publicado en 2017

Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line

artículo científico publicado en 2015

Physicochemical Profiling of Sartans: A Detailed Study of Ionization Constants and Distribution Coefficients

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates

artículo científico publicado en 2010

Plant Metabolomics – Strategies for Biomarker Detection, Isolation, and Identification

article

Predicting both passive intestinal absorption and the dissociation constant toward albumin using the PAMPA technique

artículo científico publicado en 2014

Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA).

artículo científico publicado en 2016

Quantitative structure-permeation relationship for iontophoretic transport across the skin

artículo científico publicado en 2007

Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation.

artículo científico publicado en 2004

Quantitative structure-permeation relationships for solute transport across silicone membranes

artículo científico publicado en 2002

Rapid determination of pK (a) values of 20 amino acids by CZE with UV and capacitively coupled contactless conductivity detections

artículo científico publicado en 2007

Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity

artículo científico publicado en 2002

Retention time prediction for dereplication of natural products (CxHyOz) in LC-MS metabolite profiling

artículo científico publicado en 2014

Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors

artículo científico publicado en 2004

Solvatochromic Analysis of Partition Coefficients in theo-Nitrophenyl Octyl Ether (o-NPOE)/Water System

Standard machine learning algorithms applied to UPLC-TOF/MS metabolic fingerprinting for the discovery of wound biomarkers in Arabidopsis thaliana

scholarly article by Julien Boccard et al published November 2010 in Chemometrics and Intelligent Laboratory Systems

Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

article by Géraldine Bouchard et al published 2003 in Physical Chemistry Chemical Physics

Stereoselective Block of hERG Channel by Bupivacaine Scrutinized at Molecular Level ⬇️

artículo científico publicado el 1 de enero de 2010

Stereoselective Inhibition of the hERG1 Potassium Channel.

artículo científico publicado en 2010

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

artículo científico publicado en 2015

Structure-Lipophilicity Relationships of Neutral and Protonatedβ-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

artículo científico publicado en 1999

Structure-Property Relationships in the Basicity and Lipophilicity of Arylalkylamine Oxides

Structure-antioxidant activity relationships in a series of NO-donor phenols

artículo científico publicado en 2008

Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis

artículo científico publicado en 2006

Study of leaf metabolome modifications induced by UV-C radiations in representative Vitis, Cissus and Cannabis species by LC-MS based metabolomics and antioxidant assays.

artículo científico publicado en 2014

Synergy at the ' Ecole de Pharmacie Genève-Lausanne ': Methodology Developments for the Treatment of Complex Metabolomic Datasets with Data Mining

article published in 2005

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

artículo científico publicado en 2013

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

artículo científico publicado en 2003

Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs

scientific article published on 08 December 2011

The Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple Analogues

artículo científico publicado en 2006

The PAMPA technique as a HTS tool for partition coefficients determination in different solvent/water systems

artículo científico publicado en 2008

The School of Pharmacy Geneva-Lausanne (EPGL) - the first ten years

artículo científico publicado en 2012

The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution

artículo científico publicado en 2010

The relative partitioning of neutral and ionised compounds in sodium dodecyl sulfate micelles measured by micellar electrokinetic capillary chromatography

artículo científico publicado en 2002

Theoretical and experimental exploration of the lipophilicity of zwitterionic drugs in the 1,2-dichloroethane/water system

artículo científico publicado en 2002

UPLC-TOF-MS for plant metabolomics: a sequential approach for wound marker analysis in Arabidopsis thaliana

artículo científico publicado en 2008

Ultra high pressure liquid chromatography for crude plant extract profiling

artículo científico publicado el 1 de enero de 2011

Unsymmetrical binding modes of the HOPNO inhibitor of tyrosinase: from model complexes to the enzyme

artículo científico publicado en 2013

Water-oil partition profiling of ionized drug molecules using cyclic voltammetry and a 96-well microfilter plate system

artículo científico publicado en 2003

cIEF for rapid pKa determination of small molecules: a proof of concept

artículo científico publicado en 2014

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda