Lista de obras -

(R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes

scientific article published on 21 September 2018

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 ⬇️

artículo científico publicado el 1 de noviembre de 2011

123I-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation ⬇️

artículo científico publicado el 12 de noviembre de 2010

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

artículo científico publicado en 2015

2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.

scientific article published on 09 January 2013

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

artículo científico publicado en 2003

Aberrant cannabinoid signaling impairs oviductal transport of embryos

artículo científico

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

artículo científico publicado en 2015

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

artículo científico publicado en 2017

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

artículo científico publicado en 2015

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

artículo científico publicado en 2002

Analysis of endocannabinoids, their congeners and COX-2 metabolites

artículo científico publicado en 2009

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

artículo científico publicado en 2016

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors

artículo científico publicado en 2016

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication

artículo científico publicado en 2003

Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.

artículo científico publicado en 2016

Cannabinoids, endocannabinoids, and cancer

artículo científico publicado en 2011

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

artículo científico publicado en 2010

Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase

artículo científico publicado en 2009

Chemical stability of 2-arachidonylglycerol under biological conditions

artículo científico publicado en 2002

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

artículo científico publicado en 2014

Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.

artículo científico publicado en 2014

Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics

artículo científico publicado en 2015

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

artículo científico publicado en 2002

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

artículo científico publicado en 2012

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold ⬇️

artículo científico publicado el 14 de febrero de 2012

Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.

artículo científico publicado en 2014

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents ⬇️

artículo científico publicado el 28 de marzo de 2013

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

artículo científico publicado en 2018

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

artículo científico publicado en 2002

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

artículo científico publicado en 2013

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

artículo científico publicado en 2006

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

artículo científico publicado en 2009

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

artículo científico publicado en 2019

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

artículo científico publicado en 2018

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers

artículo científico publicado en 2013

Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

artículo científico publicado en 2016

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways ⬇️

artículo científico publicado el 19 de septiembre de 2011

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

artículo científico publicado en 2017

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

artículo científico publicado en 2013

Fatty acid amide hydrolase deficiency limits early pregnancy events

artículo científico publicado en 2006

Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site

scientific article published on 18 April 2019

Fluorescent probes of the apoptolidins and their utility in cellular localization studies

artículo científico publicado en 2014

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer ⬇️

artículo científico publicado el 7 de septiembre de 2011

Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization

artículo científico publicado en 2016

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

artículo científico publicado en 2016

Functional Implications of Biochemical and Molecular Characteristics of Donation After Circulatory Death Livers

artículo científico publicado en 2015

Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide

artículo científico publicado en 2003

Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

artículo científico publicado en 2014

Genetic loss of Faah compromises male fertility in mice

artículo científico publicado en 2008

Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors

artículo científico publicado en 2020

High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins ⬇️

artículo científico publicado el 1 de septiembre de 2011

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

artículo científico publicado en 2016

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

scientific article published on 01 July 2019

Identification and functional characterization of brainstem cannabinoid CB2 receptors

artículo científico publicado en 2005

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

artículo científico publicado en 2007

Identifying mechanism-of-action targets for drugs and probes.

artículo científico publicado en 2012

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

artículo científico publicado en 2006

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

artículo científico publicado en 2005

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde ⬇️

artículo científico publicado el 5 de noviembre de 2003

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

artículo científico publicado en 2005

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

artículo científico publicado en 2016

Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡

artículo científico publicado en 2008

Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry ⬇️

artículo científico publicado en 2010

Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

artículo científico publicado en 2004

Metabolism in vitro and in vivo of the DNA base adduct, M1G.

artículo científico publicado en 2007

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

artículo científico publicado en 2002

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen

artículo científico publicado en 2010

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

artículo científico publicado en 2008

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

artículo científico publicado en 2015

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

artículo científico publicado en 2014

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

artículo científico publicado en 2014

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

artículo científico publicado en 2008

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

artículo científico publicado en 2014

Podophyllotoxin analogues active versus Trypanosoma brucei

artículo científico publicado en 2010

Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.

artículo científico publicado en 2009

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

artículo científico publicado en 2017

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

artículo científico publicado en 2017

Protein modification by adenine propenal

artículo científico publicado en 2014

Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

artículo científico publicado en 2016

RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal

artículo científico publicado en 2013

Recent developments in cyclooxygenase inhibition

artículo científico publicado en 2002

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase

artículo científico publicado en 2002

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

artículo científico publicado en 2009

Seeing it through: translational validation of new medical imaging modalities

artículo científico publicado en 2012

Selection of Monoclonal Antibodies Against 6-oxo-M1dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M1dG in Vivo ⬇️

artículo científico publicado el 24 de enero de 2012

Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.

artículo científico publicado en 2002

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents

artículo científico publicado en 2010

Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs

artículo científico publicado en 2020

Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,

artículo científico publicado en 2009

Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides

artículo científico publicado en 2007

Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells

artículo científico publicado en 2010

Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. ⬇️

artículo científico publicado en 2014

Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2

artículo científico publicado en 2002

Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene

artículo científico publicado en 2002

Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites

artículo científico publicado en 2004

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

artículo científico publicado en 2012

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

artículo científico publicado en 2014

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

artículo científico publicado en 2013

Systems analysis of protein modification and cellular responses induced by electrophile stress

artículo científico publicado en 2010

Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer

artículo científico publicado en 2019

Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe

artículo científico publicado en 2015

The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor ⬇️

artículo científico publicado el 25 de marzo de 2013

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

artículo científico publicado en 2004

The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives

scientific article published on 23 April 2009

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

artículo científico publicado en 2003

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance ⬇️

artículo científico publicado el 16 de noviembre de 2011

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

artículo científico publicado en 2010

Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human tumor xenografts

artículo científico publicado en 2014

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

artículo científico publicado en 2015

Lista de obras de

(R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 ⬇️

123I-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation ⬇️

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

Aberrant cannabinoid signaling impairs oviductal transport of embryos

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

Analysis of endocannabinoids, their congeners and COX-2 metabolites

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication

Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.

Cannabinoids, endocannabinoids, and cancer

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase

Chemical stability of 2-arachidonylglycerol under biological conditions

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.

Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold ⬇️

Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents ⬇️

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers

Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways ⬇️

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

Fatty acid amide hydrolase deficiency limits early pregnancy events

Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site

Fluorescent probes of the apoptolidins and their utility in cellular localization studies

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer ⬇️

Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

Functional Implications of Biochemical and Molecular Characteristics of Donation After Circulatory Death Livers

Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide

Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

Genetic loss of Faah compromises male fertility in mice

Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors

High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins ⬇️

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

Identification and functional characterization of brainstem cannabinoid CB2 receptors

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

Identifying mechanism-of-action targets for drugs and probes.

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde ⬇️

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡

Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry ⬇️

Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Metabolism in vitro and in vivo of the DNA base adduct, M1G.

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

Podophyllotoxin analogues active versus Trypanosoma brucei

Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Protein modification by adenine propenal