Lista de obras -

193 nm Ultraviolet Photodissociation Mass Spectrometry for Phosphopeptide Characterization in the Positive and Negative Ion Modes

artículo científico publicado en 2016

193‐nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization ⬇️

artículo científico publicado el 17 de febrero de 2011

A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers

artículo científico publicado en 2020

A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase

artículo científico publicado en 2017

A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach ⬇️

artículo científico publicado el 11 de abril de 2011

A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation

scientific article published on 13 May 2019

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.

artículo científico publicado en 2017

A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay.

artículo científico publicado en 2017

A tunable assay for modulators of genome-destabilizing DNA structures

artículo científico publicado en 2019

Activated ERK2 Is a Monomer in Vitro with or without Divalent Cations and When Complexed to the Cytoplasmic Scaffold PEA-15 ⬇️

artículo científico publicado el 4 de mayo de 2011

Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.

artículo científico publicado en 2016

Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding

artículo científico publicado en 2013

Arrestin-3 interaction with maternal embryonic leucine-zipper kinase

artículo científico publicado en 2019

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

scientific article published on 27 December 2018

Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs).

artículo científico publicado en 2015

Assignment of Backbone Resonances in a Eukaryotic Protein Kinase – ERK2 as a Representative Example ⬇️

artículo científico publicado el 1 de enero de 2012

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

artículo científico publicado en 2018

Charge‐Site‐Dependent Dissociation of Hydrogen‐Rich Radical Peptide Cations upon Vacuum UV Photoexcitation ⬇️

artículo científico publicado el 16 de marzo de 2012

Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases ⬇️

artículo científico publicado el 1 de enero de 2012

Computational and Experimental Studies of Inhibitor Design for Aldolase A

scientific article published on 03 July 2019

Computational insights into the binding of IN17 inhibitors to MELK

scientific article published on 08 May 2019

Construction of human activity-based phosphorylation networks.

artículo científico publicado en 2013

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target

artículo científico publicado en 2016

Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma

artículo científico publicado en 2018

Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3]propellane derivatives: Potential anticancer agents

artículo científico publicado en 2019

Developing Colorimetric and Luminescence-Based High-Throughput Screening Platforms for Monitoring the GTPase Activity of Ferrous Iron Transport Protein B (FeoB)

scientific article published on 30 April 2019

Development of a High-Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small-Molecule Inhibitors against LH2

artículo científico publicado en 2018

Development of a cost effective and robust AlphaScreen® platform for application.

artículo científico publicado en 2018

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth

artículo científico publicado en 2017

Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α.

artículo científico publicado en 2012

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

artículo científico publicado en 2022

Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods

artículo científico publicado en 2013

Elucidating the Phosphate Binding Mode of Phosphate-Binding Protein: The Critical Effect of Buffer Solution.

artículo científico publicado en 2018

Examining Docking Interactions on ERK2 with Modular Peptide Substrates ⬇️

artículo científico publicado el 18 de octubre de 2011

From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules ⬇️

artículo científico publicado el 6 de agosto de 2012

Identification and validation of novel PERK inhibitors

artículo científico publicado en 2014

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK ⬇️

artículo científico publicado el 16 de enero de 1998

In-situ generation of differential sensors that fingerprint kinases and the cellular response to their expression

artículo científico publicado en 2013

JNK Signaling in Stem Cell Self-Renewal and Differentiation

scientific article published on 09 April 2020

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells

scientific article published on 17 May 2019

Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2.

artículo científico publicado en 2017

Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells.

artículo científico publicado en 2016

MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.

artículo científico publicado en 2017

Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers.

artículo científico publicado en 2015

Modeling organochlorine compounds and the σ-hole effect using a polarizable multipole force field

artículo científico publicado en 2014

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

scientific article published on 19 November 2019

NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth

artículo científico publicado en 2019

Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations

artículo científico publicado en 2017

Optimization of a Luminescence-Based High-Throughput Screening Assay for Detecting Apyrase Activity

artículo científico publicado en 2016

Overexpression of GRK6 rescues L-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats.

artículo científico publicado en 2015

Peptide mini-scaffold facilitates JNK3 activation in cells

artículo científico

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

artículo científico publicado en 2018

Quantification of ERK Kinase Activity in Biological Samples Using Differential Sensing

artículo científico publicado en 2019

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

artículo científico publicado en 2014

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth

artículo científico publicado en 2017

Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

artículo científico publicado en 2016

Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition

artículo científico publicado en 2019

Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin

artículo científico publicado en 2016

Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin.

artículo científico publicado en 2018

Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase

artículo científico publicado en 2016

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

artículo científico publicado en 2014

Targeting ERK beyond the boundaries of the kinase active site in melanoma

artículo científico publicado en 2019

The molecular mechanism of eukaryotic elongation factor 2 kinase activation

artículo científico publicado en 2014

The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase

scientific article published on 01 December 2019

Tinker-OpenMM: Absolute and relative alchemical free energies using AMOEBA on GPUs.

artículo científico publicado en 2017

Two Rate-Limiting Steps in the Kinetic Mechanism of the Serine/Threonine Specific Protein Kinase ERK2: A Case of Fast Phosphorylation Followed by Fast Product Release ⬇️

artículo científico publicado el 28 de octubre de 2003

Understanding the Specificity of a Docking Interaction between JNK1 and the Scaffolding Protein JIP1 ⬇️

artículo científico publicado el 25 de enero de 2011

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

artículo científico publicado en 2015

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

artículo científico publicado en 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de

193 nm Ultraviolet Photodissociation Mass Spectrometry for Phosphopeptide Characterization in the Positive and Negative Ion Modes

193‐nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization ⬇️

A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers

A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase

A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach ⬇️

A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.

A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay.

A tunable assay for modulators of genome-destabilizing DNA structures

Activated ERK2 Is a Monomer in Vitro with or without Divalent Cations and When Complexed to the Cytoplasmic Scaffold PEA-15 ⬇️

Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.

Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding

Arrestin-3 interaction with maternal embryonic leucine-zipper kinase

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs).

Assignment of Backbone Resonances in a Eukaryotic Protein Kinase – ERK2 as a Representative Example ⬇️

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

Charge‐Site‐Dependent Dissociation of Hydrogen‐Rich Radical Peptide Cations upon Vacuum UV Photoexcitation ⬇️

Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases ⬇️

Computational and Experimental Studies of Inhibitor Design for Aldolase A

Computational insights into the binding of IN17 inhibitors to MELK

Construction of human activity-based phosphorylation networks.

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target

Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma

Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3]propellane derivatives: Potential anticancer agents

Developing Colorimetric and Luminescence-Based High-Throughput Screening Platforms for Monitoring the GTPase Activity of Ferrous Iron Transport Protein B (FeoB)

Development of a High-Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small-Molecule Inhibitors against LH2

Development of a cost effective and robust AlphaScreen® platform for application.

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth

Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α.

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods

Elucidating the Phosphate Binding Mode of Phosphate-Binding Protein: The Critical Effect of Buffer Solution.

Examining Docking Interactions on ERK2 with Modular Peptide Substrates ⬇️

From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules ⬇️

Identification and validation of novel PERK inhibitors

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK ⬇️

In-situ generation of differential sensors that fingerprint kinases and the cellular response to their expression

JNK Signaling in Stem Cell Self-Renewal and Differentiation

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells

Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2.

Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells.

MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.

Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers.

Modeling organochlorine compounds and the σ-hole effect using a polarizable multipole force field

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth

Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations

Optimization of a Luminescence-Based High-Throughput Screening Assay for Detecting Apyrase Activity

Overexpression of GRK6 rescues L-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats.

Peptide mini-scaffold facilitates JNK3 activation in cells

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.

Quantification of ERK Kinase Activity in Biological Samples Using Differential Sensing

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth

Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition

Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin

Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin.

Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

Targeting ERK beyond the boundaries of the kinase active site in melanoma

The molecular mechanism of eukaryotic elongation factor 2 kinase activation

The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase

Tinker-OpenMM: Absolute and relative alchemical free energies using AMOEBA on GPUs.

Two Rate-Limiting Steps in the Kinetic Mechanism of the Serine/Threonine Specific Protein Kinase ERK2: A Case of Fast Phosphorylation Followed by Fast Product Release ⬇️

Understanding the Specificity of a Docking Interaction between JNK1 and the Scaffolding Protein JIP1 ⬇️

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)