Lista de obras -

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

artículo científico publicado en 2015

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data

scientific article published on 26 November 2020

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

artículo científico publicado en 2013

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

artículo científico publicado en 2015

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

artículo científico publicado en 2016

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

artículo científico

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

artículo científico publicado en 2016

ApoE plasma levels and risk of cardiovascular mortality in old age

artículo científico publicado en 2006

Are skin senescence and immunosenescence linked within individuals?

artículo científico publicado en 2019

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

artículo científico publicado en 2015

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

artículo científico publicado en 2016

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity

artículo científico publicado en 2014

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

scientific article published on 15 December 2020

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

C-reactive protein and glucose regulation in familial longevity

artículo científico publicado en 2011

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

artículo científico publicado en 2005

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

artículo científico publicado en 2015

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

artículo científico publicado en 2011

Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

scientific article published on 20 August 2020

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

artículo científico publicado en 2016

Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts

artículo científico publicado en 2008

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

artículo científico publicado en 2012

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

artículo científico publicado en 2012

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

artículo científico publicado en 2018

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

artículo científico publicado en 2014

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

artículo científico publicado en 2019

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

artículo científico publicado en 2013

Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion

artículo científico publicado en 2017

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

artículo científico publicado en 2016

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

artículo científico publicado en 2012

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

artículo científico publicado en 2015

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

artículo científico publicado en 2016

Familial longevity is associated with decreased thyroid function

artículo científico publicado en 2010

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

artículo científico publicado en 2013

Familial longevity is marked by enhanced insulin sensitivity

artículo científico publicado en 2010

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

artículo científico publicado en 2012

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

artículo científico publicado en 2010

Gene expression analysis of mTOR pathway: association with human longevity

artículo científico publicado en 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

artículo científico publicado en 2011

Genes encoding longevity: from model organisms to humans

artículo científico publicado en 2008

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

artículo científico publicado en 2006

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

artículo científico publicado en 2017

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

artículo científico publicado en 2018

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

artículo científico publicado en 2014

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

artículo científico publicado en 2011

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

artículo científico publicado en 2018

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

artículo científico publicado en 2016

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

artículo científico publicado en 2016

Genomics of human longevity.

artículo científico publicado en 2011

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

artículo científico publicado en 2016

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

artículo científico publicado en 2017

High serum glucose levels are associated with a higher perceived age.

artículo científico publicado en 2011

Homocysteine and familial longevity: the Leiden Longevity Study

artículo científico publicado en 2011

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

artículo científico publicado en 2017

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

article

Human insulin/IGF-1 and familial longevity at middle age.

artículo científico publicado en 2009

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

artículo científico publicado en 2015

IL7R gene expression network associates with human healthy ageing

artículo científico publicado en 2015

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

IgG glycosylation and DNA methylation are interconnected with smoking

artículo científico publicado en 2017

Impact of genetic variations in the WRN gene on age related pathologies and mortality

scientific article published on 06 January 2006

Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians

artículo científico publicado en 2008

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

artículo científico publicado en 2020

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

artículo científico publicado en 2012

Lifestyle and youthful looks.

artículo científico publicado en 2015

Lipid metabolism in long-lived families: the Leiden Longevity Study

artículo científico publicado en 2010

Liver X receptor alpha associates with human life span

scientific article published on 01 April 2007

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

artículo científico publicado en 2009

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

artículo científico publicado en 2020

Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors

artículo científico publicado en 2006

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.

artículo científico publicado en 2012

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

artículo científico publicado en 2011

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

artículo científico publicado en 2019

No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

artículo científico publicado en 2017

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

artículo científico publicado en 2009

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

artículo científico publicado en 2015

Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

artículo científico publicado en 2015

Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians

artículo científico publicado en 2007

Plasma apolipoprotein CI protects against mortality from infection in old age.

artículo científico publicado en 2008

Plasma levels of apolipoprotein E and cognitive function in old age.

artículo científico publicado en 2007

Plasma levels of apolipoprotein E and risk of stroke in old age.

artículo científico publicado en 2007

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

artículo científico publicado en 2011

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

artículo científico publicado en 2013

Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

artículo científico publicado en 2011

Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts

artículo científico publicado en 2009

Reduced insulin/IGF-1 signalling and human longevity.

artículo científico publicado en 2005

Relation between body height and replicative capacity of human fibroblasts in nonagenarians

artículo científico publicado en 2008

Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro.

artículo científico publicado en 2010

Renal function in familial longevity: the Leiden Longevity Study.

artículo científico publicado en 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

artículo científico publicado en 2020

SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

artículo científico publicado en 2007

Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

artículo científico publicado en 2013

Serum triiodothyronine levels and inflammatory cytokine production capacity

artículo científico publicado en 2011

Stress-induced responses of human skin fibroblasts in vitro reflect human longevity

artículo científico publicado en 2009

Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.

artículo científico publicado en 2013

The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat

scientific article published on 28 September 2019

The Association between Habitual Sleep Duration and Sleep Quality with Glycemic Traits: Assessment by Cross-Sectional and Mendelian Randomization Analyses

scientific article published on 15 May 2019

The MC1R Gene and Youthful Looks

artículo científico publicado en 2016

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

article

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

artículo científico publicado en 2016

The number of p16INK4a positive cells in human skin reflects biological age.

artículo científico publicado en 2012

Thyroid status and mortality in nonagenarians from long-lived families and the general population

artículo científico publicado en 2017

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

artículo científico publicado en 2012

VDR gene variants associate with cognitive function and depressive symptoms in old age.

artículo científico publicado en 2007

Variation in the SHC1 gene and longevity in humans

artículo científico publicado en 2004

Variation in the human TP53 gene affects old age survival and cancer mortality.

artículo científico publicado en 2005

Lista de obras de

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

A meta-analysis of genome-wide association studies identifies multiple longevity genes

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

ApoE plasma levels and risk of cardiovascular mortality in old age

Are skin senescence and immunosenescence linked within individuals?

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Blood lipids influence DNA methylation in circulating cells

C-reactive protein and glucose regulation in familial longevity

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

Defining the role of common variation in the genomic and biological architecture of adult human height

Disease variants alter transcription factor levels and methylation of their binding sites

Do senescence markers correlate in vitro and in situ within individual human donors?

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

Familial longevity is associated with decreased thyroid function

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

Familial longevity is marked by enhanced insulin sensitivity

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

Gene expression analysis of mTOR pathway: association with human longevity

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

Genes encoding longevity: from model organisms to humans

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

Genomics of human longevity.

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

High serum glucose levels are associated with a higher perceived age.

Homocysteine and familial longevity: the Leiden Longevity Study

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

Human insulin/IGF-1 and familial longevity at middle age.

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

IL7R gene expression network associates with human healthy ageing

Identification of context-dependent expression quantitative trait loci in whole blood

IgG glycosylation and DNA methylation are interconnected with smoking

Impact of genetic variations in the WRN gene on age related pathologies and mortality

Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

Lifestyle and youthful looks.

Lipid metabolism in long-lived families: the Leiden Longevity Study

Liver X receptor alpha associates with human life span

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study