Lista de obras -

A Population-Based Study on Myelodysplastic Syndromes in the Lazio Region (Italy), Medical Miscoding and 11-Year Mortality Follow-Up: the Gruppo Romano-Laziale Mielodisplasie Experience of Retrospective Multicentric Registry.

artículo científico publicado en 2017

A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol

artículo científico publicado en 2005

A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review

Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells.

artículo científico publicado en 2008

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

artículo científico publicado en 2005

Advances in targeting signal transduction pathways

artículo científico publicado en 2012

Aggressive lymphomas of the elderly: the DEVEC metronomic chemotherapy schedule fits the unfit.

artículo científico publicado en 2017

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

artículo científico publicado en 2008

An increase in hemoglobin, platelets and white blood cells levels by iron chelation as single treatment in multitransfused patients with myelodysplastic syndromes: clinical evidences and possible biological mechanisms

artículo científico publicado en 2015

Apoptosis susceptibility and cell-cycle distribution in cells from myelodysplastic syndrome patients: modulatory in-vitro effects of G-CSF and interferon-alpha

artículo científico publicado en 2004

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia ⬇️

artículo científico publicado en 2010

Biological Aspects of mTOR in Leukemia

scholarly article by Simone Mirabilii published in August 2018

Central nervous system immune reconstitution inflammatory syndrome after autologous stem cell transplantation

scientific article published on 08 May 2019

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

artículo científico publicado en 2015

Correlation between Charlson comorbidity index and outcome in patients with chronic phase chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors upfront.

artículo científico publicado en 2015

Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells

artículo científico publicado en 2017

Differential proteomic profile of leukemic CD34+ progenitor cells from chronic myeloid leukemia patients.

artículo científico publicado en 2018

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid) ⬇️

artículo científico publicado el 16 de mayo de 1991

E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features

scientific article published on 01 February 2003

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

artículo científico publicado en 2007

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

artículo científico publicado en 2012

Effects of IL-6 Variants in Multiple Myeloma: Growth Inhibition and Induction of Apoptosis in Primary Cells

scientific article published on 01 December 2002

Effects of mast cell growth factor on ara-c mediated acute myeloid leukemia cell killing ⬇️

artículo científico publicado el 1 de julio de 1993

Emerging MEK inhibitors.

artículo científico publicado en 2010

Emerging Raf inhibitors.

artículo científico publicado en 2009

Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin ⬇️

artículo científico publicado en 2017

Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia.

artículo científico publicado en 2016

Functional and kinetic characterization of granulocyte colony-stimulating factor-primed CD34- human stem cells

artículo científico publicado en 2003

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

artículo científico publicado en 2019

Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia

artículo científico publicado en 2004

Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations

artículo científico publicado en 2009

Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly

artículo científico publicado en 2008

Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors.

artículo científico publicado en 2013

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein ⬇️

artículo científico publicado el 14 de abril de 1998

Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.

artículo científico publicado en 2005

Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia

artículo científico publicado en 2017

Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1)

artículo científico publicado en 2002

Interleukin-9 in Human Myeloid Leukemia Cells ⬇️

artículo científico publicado el 1 de agosto de 1997

Interleukin‐3 priming in acute myeloid leukaemia patients ⬇️

artículo científico publicado el 1 de septiembre de 1995

Isolated molecular relapse in FIP1L1-PDGFRalpha hypereosinophilic syndrome after discontinuation and single weekly dose of imatinib: need of quantitative molecular procedures to modulate imatinib dose

artículo científico publicado en 2008

MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.

artículo científico publicado en 2002

MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

artículo científico publicado en 2006

Metabolic Reprogramming Promotes Myogenesis During Aging

artículo científico publicado en 2019

Modulation Of The Glycolytic Metabolism In Acute Myeloid Leukemia Cells ⬇️

artículo científico publicado en 2013

Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34- cell population with intrinsic resistance to imatinib

artículo científico publicado en 2009

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

artículo científico publicado en 2012

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells ⬇️

artículo científico publicado en 2010

Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies ⬇️

artículo científico publicado en 2007

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

artículo científico publicado en 2015

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite.

artículo científico publicado en 2017

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2008

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice.

artículo científico publicado en 2011

RETRACTED ARTICLE: MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex ⬇️

artículo científico publicado el 8 de noviembre de 2011

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

artículo científico publicado en 2012

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

artículo científico publicado en 2011

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

artículo científico publicado en 2011

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

artículo científico publicado en 2007

Targeting Glycolysis and MAPK Pathway: A Combined Pre-Clinical Approach on Acute Myeloid Leukemia ⬇️

artículo científico publicado en 2016

Targeting Metabolic Pathways for Leukemia Treatment ⬇️

scholarly article

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

artículo científico publicado en 2017

Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia.

artículo científico publicado en 2017

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

artículo científico publicado en 2008

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias.

artículo científico publicado en 2015

The Activity of Differentiation Factors Induces Apoptosis in Polyomavirus Large T-Expressing Myoblasts ⬇️

artículo científico publicado el 1 de junio de 1998

The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera

artículo científico publicado en 2017

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

artículo científico publicado en 2012

The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia

artículo científico publicado en 2015

The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling.

artículo científico publicado en 2015

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

artículo científico publicado en 2012

Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects

artículo científico publicado en 2017

Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera.

artículo científico publicado en 2013

Treatment of de novo acute myelogenous leukemia with recombinant granulocyte macrophage-colony-stimulating factor in combination with standard induction chemotherapy: effect of granulocyte macrophage-colony-stimulating factor on white blood cell cou ⬇️

artículo científico publicado el 1 de enero de 1992

Trisomy 13 in a patient with common acute lymphoblastic leukemia: description of a case and review of the literature

artículo científico publicado en 2003

mTOR Regulation of Metabolism in Hematologic Malignancies

scientific article published on 11 February 2020

Lista de obras de

A Population-Based Study on Myelodysplastic Syndromes in the Lazio Region (Italy), Medical Miscoding and 11-Year Mortality Follow-Up: the Gruppo Romano-Laziale Mielodisplasie Experience of Retrospective Multicentric Registry.

A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol

A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review

Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells.

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

Advances in targeting signal transduction pathways

Aggressive lymphomas of the elderly: the DEVEC metronomic chemotherapy schedule fits the unfit.

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

An increase in hemoglobin, platelets and white blood cells levels by iron chelation as single treatment in multitransfused patients with myelodysplastic syndromes: clinical evidences and possible biological mechanisms

Apoptosis susceptibility and cell-cycle distribution in cells from myelodysplastic syndrome patients: modulatory in-vitro effects of G-CSF and interferon-alpha

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia ⬇️

Biological Aspects of mTOR in Leukemia

Central nervous system immune reconstitution inflammatory syndrome after autologous stem cell transplantation

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

Correlation between Charlson comorbidity index and outcome in patients with chronic phase chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors upfront.

Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells

Differential proteomic profile of leukemic CD34+ progenitor cells from chronic myeloid leukemia patients.

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid) ⬇️

E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

Effects of IL-6 Variants in Multiple Myeloma: Growth Inhibition and Induction of Apoptosis in Primary Cells

Effects of mast cell growth factor on ara-c mediated acute myeloid leukemia cell killing ⬇️

Emerging MEK inhibitors.

Emerging Raf inhibitors.

Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin ⬇️

Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia.

Functional and kinetic characterization of granulocyte colony-stimulating factor-primed CD34- human stem cells

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia

Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations

Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly

Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors.

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein ⬇️

Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.

Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia

Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1)

Interleukin-9 in Human Myeloid Leukemia Cells ⬇️

Interleukin‐3 priming in acute myeloid leukaemia patients ⬇️

Isolated molecular relapse in FIP1L1-PDGFRalpha hypereosinophilic syndrome after discontinuation and single weekly dose of imatinib: need of quantitative molecular procedures to modulate imatinib dose

MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.

MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

Metabolic Reprogramming Promotes Myogenesis During Aging

Modulation Of The Glycolytic Metabolism In Acute Myeloid Leukemia Cells ⬇️

Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34- cell population with intrinsic resistance to imatinib

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells ⬇️

Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies ⬇️

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite.

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice.

RETRACTED ARTICLE: MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex ⬇️

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

Targeting Glycolysis and MAPK Pathway: A Combined Pre-Clinical Approach on Acute Myeloid Leukemia ⬇️

Targeting Metabolic Pathways for Leukemia Treatment ⬇️

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia.

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias.

The Activity of Differentiation Factors Induces Apoptosis in Polyomavirus Large T-Expressing Myoblasts ⬇️

The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia

The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling.

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects

Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera.

Treatment of de novo acute myelogenous leukemia with recombinant granulocyte macrophage-colony-stimulating factor in combination with standard induction chemotherapy: effect of granulocyte macrophage-colony-stimulating factor on white blood cell cou ⬇️

Trisomy 13 in a patient with common acute lymphoblastic leukemia: description of a case and review of the literature

mTOR Regulation of Metabolism in Hematologic Malignancies