Lista de obras -

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents

artículo científico publicado en 2016

7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.

artículo científico publicado en 2018

A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes

artículo científico publicado en 2019

A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions

scientific article published on 04 April 2019

A chemically-controlled system for activating RAS GTPases

scientific article published on 22 November 2019

A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics

artículo científico publicado en 2016

A hexylchloride-based catch-and-release system for chemical proteomic applications.

artículo científico publicado en 2013

A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.

artículo científico publicado en 2013

A novel protein kinase is essential in bloodstream Trypanosoma brucei

scientific article published on 23 March 2016

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

artículo científico publicado en 2013

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR

artículo científico publicado en 2021

Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors

artículo científico publicado en 2018

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

artículo científico publicado en 2014

Bivalent inhibitors of protein kinases

artículo científico publicado en 2014

Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.

artículo científico publicado en 2014

Bumped kinase inhibitor prohibits egression in Babesia bovis

artículo científico publicado en 2015

Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes

scientific article published on 05 July 2019

Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases

artículo científico publicado en 2014

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

artículo científico publicado en 2013

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

artículo científico publicado en 2016

Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1

artículo científico publicado en 2019

Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.

artículo científico publicado en 2017

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

scientific article published on 16 June 2016

Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.

artículo científico publicado en 2014

Druggable sensors of the unfolded protein response

artículo científico publicado en 2014

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

artículo científico publicado en 2017

How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture

artículo científico publicado en 2020

In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

artículo científico publicado en 2015

Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.

artículo científico publicado en 2017

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

artículo científico publicado en 2020

Label Transfer Reagents to Probe p38 MAPK Binding Partners ⬇️

artículo científico publicado el 14 de enero de 2013

Multi-input chemical control of protein dimerization for programming graded cellular responses

artículo científico publicado en 2019

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

artículo científico publicado en 2016

Parallel Chemoselective Profiling for Mapping Protein Structure

artículo científico publicado en 2020

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

artículo científico publicado en 2014

Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α

artículo científico publicado en 2017

Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma

artículo científico publicado en 2014

Rapid profiling of protein kinase inhibitors by quantitative proteomics.

artículo científico publicado en 2014

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

artículo científico publicado en 2017

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

artículo científico publicado en 2017

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

artículo científico publicado en 2015

SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.

artículo científico publicado en 2014

Structural and functional analysis of the allosteric inhibition of IRE1α with ATP-competitive ligands

artículo científico publicado en 2016

Subcellular drug targeting illuminates local kinase action

artículo científico publicado en 2019

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

artículo científico publicado en 2020

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

artículo científico publicado en 2017

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

artículo científico publicado en 2017

Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases

scientific article published on 13 May 2019

The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function

artículo científico publicado en 2020

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

artículo científico publicado en 2014

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.

artículo científico publicado en 2017

Lista de obras de

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents

7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.

A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes

A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions

A chemically-controlled system for activating RAS GTPases

A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics

A hexylchloride-based catch-and-release system for chemical proteomic applications.

A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.

A novel protein kinase is essential in bloodstream Trypanosoma brucei

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR

Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Bivalent inhibitors of protein kinases

Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.

Bumped kinase inhibitor prohibits egression in Babesia bovis

Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes

Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1

Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.

Druggable sensors of the unfolded protein response

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture

In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

Label Transfer Reagents to Probe p38 MAPK Binding Partners ⬇️

Multi-input chemical control of protein dimerization for programming graded cellular responses

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Parallel Chemoselective Profiling for Mapping Protein Structure

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α

Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma

Rapid profiling of protein kinase inhibitors by quantitative proteomics.

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.

Structural and functional analysis of the allosteric inhibition of IRE1α with ATP-competitive ligands

Subcellular drug targeting illuminates local kinase action

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases

The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.