Lista de obras -

2-Deoxy-d-Glucose Ameliorates PKD Progression

artículo científico publicado en 2015

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

artículo científico publicado en 2009

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

artículo científico publicado en 2006

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

artículo científico publicado en 2018

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

artículo científico publicado en 2014

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

artículo científico publicado en 2002

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

artículo científico publicado en 2000

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

artículo científico publicado en 2016

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

artículo científico publicado en 2013

Defective glycolysis and the use of 2-deoxy-D-glucose in polycystic kidney disease: from animal models to humans.

artículo científico publicado en 2017

Defective metabolism in polycystic kidney disease: potential for therapy and open questions.

artículo científico

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

scientific article published on 16 November 2018

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

artículo científico publicado en 2016

Emerging evidence of a link between the polycystins and the mTOR pathways

artículo científico publicado en 2009

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

artículo científico publicado en 2010

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

artículo científico publicado en 2014

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression

scientific article published on 02 April 2020

Individualized anticoagulation with dermatan sulphate for haemodialysis in chronic renal failure ⬇️

artículo científico publicado el 1 de noviembre de 1997

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

artículo científico publicado en 2015

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

scientific article published on 06 December 2019

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

artículo científico publicado en 2020

Metabolism and mitochondria in polycystic kidney disease research and therapy

scientific article published on 01 November 2018

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals

artículo científico publicado en 2010

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

artículo científico publicado en 2014

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

artículo científico publicado en 2014

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium.

artículo científico publicado en 2012

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation.

artículo científico publicado en 2015

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

scientific journal article

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

artículo científico publicado en 2015

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

scientific article published on 12 November 2019

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

artículo científico publicado en 2013

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

artículo científico publicado en 2007

Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

artículo científico publicado en 2006

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells

artículo científico publicado en 2011

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

artículo científico publicado en 2014

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

artículo científico publicado en 2009

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

artículo científico publicado en 2012

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

artículo científico publicado en 2010

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

artículo científico publicado en 2015

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling

artículo científico publicado en 2014

Role of polycystins in renal tubulogenesis

artículo científico publicado en 2003

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

scientific article published on 20 November 2020

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

artículo científico publicado en 2015

Slowing Polycystic Kidney Disease by Fasting

artículo científico publicado en 2015

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

scientific article published on 05 August 2019

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

artículo científico publicado en 2017

The ciliopathies--Polycystic Kidney Disease

artículo científico publicado en 2015

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

artículo científico publicado en 2016

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

artículo científico publicado en 2016

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

scientific article published in 2017

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

scientific article published on 20 November 2018

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

artículo científico publicado en 2016

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma

artículo científico publicado en 2018

Lista de obras de

2-Deoxy-d-Glucose Ameliorates PKD Progression

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Defective glycolysis and the use of 2-deoxy-D-glucose in polycystic kidney disease: from animal models to humans.

Defective metabolism in polycystic kidney disease: potential for therapy and open questions.

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

Emerging evidence of a link between the polycystins and the mTOR pathways

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression

Individualized anticoagulation with dermatan sulphate for haemodialysis in chronic renal failure ⬇️

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

Metabolism and mitochondria in polycystic kidney disease research and therapy

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium.

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation.

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling

Role of polycystins in renal tubulogenesis

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

Slowing Polycystic Kidney Disease by Fasting

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

The ciliopathies--Polycystic Kidney Disease

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma