Lista de obras -

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

scientific article published on 06 August 2019

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

artículo científico publicado en 2020

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

artículo científico publicado en 2010

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

artículo científico publicado en 2017

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

scientific article published on 15 September 2020

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

artículo científico publicado en 2012

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

scientific journal article

Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis

artículo científico publicado en 2021

Insights into cytokine-receptor interactions from cytokine engineering

artículo científico publicado en 2015

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

artículo científico publicado en 2015

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

artículo científico publicado en 2019

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells

artículo científico publicado en 2008

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

artículo científico publicado en 2017

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22:

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

artículo científico publicado en 2019

Mapping Determinants of Cytokine Signaling via Protein Engineering

artículo científico publicado en 2018

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

artículo científico publicado en 2020

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

artículo científico publicado en 2012

Multifarious determinants of cytokine receptor signaling specificity.

artículo científico

Receptor density is key to the alpha2/beta interferon differential activities.

scientific article published on 29 June 2009

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

artículo científico publicado en 2016

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

artículo científico publicado en 2012

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

artículo científico publicado en 2007

SS2-3 A cross-talk between the Stat3/SOCS3 and the IRS-1/PI3K/p70S6K pathways regulates antiproliferative activity of IFNβ

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

artículo científico publicado en 2011

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

artículo científico publicado en 2024

Superkines: cytokines displaying better targeted functions

artículo científico publicado en 2013

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

artículo científico publicado en 2017

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

artículo científico publicado en 2017

The role of RPGR in cilia formation and actin stability

artículo científico publicado en 2011

Translational control as the basis of the differential antiproliferative potency of IFNα2 and IFNβ

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

artículo científico

Lista de obras de

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis

Insights into cytokine-receptor interactions from cytokine engineering

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22:

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Mapping Determinants of Cytokine Signaling via Protein Engineering

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Multifarious determinants of cytokine receptor signaling specificity.

Receptor density is key to the alpha2/beta interferon differential activities.

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

SS2-3 A cross-talk between the Stat3/SOCS3 and the IRS-1/PI3K/p70S6K pathways regulates antiproliferative activity of IFNβ

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Superkines: cytokines displaying better targeted functions

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

The role of RPGR in cilia formation and actin stability

Translational control as the basis of the differential antiproliferative potency of IFNα2 and IFNβ

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands