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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

artículo científico publicado en 2019

Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

artículo científico publicado en 2020

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

artículo científico publicado en 2013

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

artículo científico publicado en 2019

Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity

artículo científico publicado en 2012

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

scientific article published on 13 December 2019

Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance

artículo científico publicado en 2015

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

scientific article published on 15 February 2019

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

artículo científico publicado en 2018

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction

scientific article published on 01 October 2019

Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy

artículo científico publicado el 1 de diciembre de 2010

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

artículo científico publicado en 2014

Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

artículo científico publicado en 2019

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.

artículo científico publicado en 2018

TDP-43/FUS in motor neuron disease: Complexity and challenges.

artículo científico publicado en 2016

Tau tubulin kinases in proteinopathy

artículo científico publicado en 2019

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

artículo científico publicado en 2016

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43

artículo científico publicado en 2014