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8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

artículo científico publicado en 2017

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

artículo científico publicado en 2018

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

artículo científico publicado en 2016

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

artículo científico publicado en 2014

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages.

artículo científico publicado en 2017

DOTA-Amide Lanthanide Tag for Reliable Generation of Pseudocontact Shifts in Protein NMR Spectra

article

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

artículo científico publicado en 2015

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and β2 adrenergic receptors

artículo científico publicado en 2013

Enhanced Cytotoxicity through Conjugation of a "Clickable" Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

artículo científico publicado en 2014

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

artículo científico publicado en 2013

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

artículo científico publicado en 2016

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

artículo científico publicado en 2017

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

artículo científico publicado en 2015

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

artículo científico publicado en 2014