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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

scientific article published on 09 January 2019

A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family

artículo científico publicado en 2019

Age-related modulation of γ-secretase activity in non-human primate brains.

artículo científico publicado en 2012

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease

artículo científico publicado en 2018

Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting γ-cleavage of amyloid precursor protein.

artículo científico publicado en 2010

Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates.

artículo científico publicado en 2016

Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

artículo científico publicado en 2022

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

scientific article published on 05 December 2019

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life

artículo científico publicado en 2019

Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.

artículo científico publicado en 2016

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

artículo científico publicado en 2020

Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.

artículo científico publicado en 2015

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.

artículo científico publicado en 2014

Verubecestat for Prodromal Alzheimer's Disease

artículo científico publicado en 2019

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