Lista de obras -

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis

artículo científico publicado en 2014

An anti-tetraamination of a 1,3-diene unit via cascade annulations of the azulenone scaffold with dicarbonyl azo-compounds

artículo científico publicado en 2010

An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation ⬇️

artículo científico publicado en 2005

Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences

scientific article published on 18 July 2019

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

artículo científico publicado en 2013

Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis

artículo científico publicado en 2004

Biosynthesis of indole diterpenes, emindole, and paxilline: involvement of a common intermediate

artículo científico publicado en 2004

Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene

artículo científico publicado en 2004

Biosynthetic Machinery of 6-Hydroxymellein Derivatives Leading to Cyclohelminthols and Palmaenones

artículo científico publicado en 2019

Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.

artículo científico publicado en 2017

Biosynthetic gene-based secondary metabolite screening: a new diterpene, methyl phomopsenonate, from the fungus Phomopsis amygdali.

artículo científico publicado en 2009

Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part

artículo científico publicado en 2006

Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase

article

Characterization of a rice gene family encoding type-A diterpene cyclases

artículo científico publicado en 2006

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

artículo científico publicado en 2018

Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.

artículo científico publicado en 2004

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

artículo científico publicado en 2008

Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis

artículo científico publicado en 2011

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes

artículo científico publicado en 2017

Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants

artículo científico publicado en 2018

Design and De Novo Synthesis of 6-Aza-artemisinins

artículo científico publicado en 2018

Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice ⬇️

artículo científico publicado en 2004

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

artículo científico publicado en 2009

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

artículo científico publicado en 2009

Efficient Reconstitution of Basidiomycota Diterpene Erinacine Gene Cluster in Ascomycota Host Aspergillus oryzae Based on Genomic DNA Sequences

scientific article published on 24 September 2019

Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi

scientific article published on 21 May 2019

Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit

artículo científico publicado en 2018

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

artículo científico publicado en 2012

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

artículo científico publicado en 2011

Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs

artículo científico publicado en 2008

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

artículo científico publicado en 2008

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product ⬇️

artículo científico publicado en 2009

Expression of Alternaria solani PKSF generates a set of complex reduced-type polyketides with different carbon-lengths and cyclization

artículo científico publicado en 2006

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

artículo científico publicado en 2020

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products

artículo científico publicado en 2017

Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster ⬇️

artículo científico publicado el 24 de marzo de 2013

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues ⬇️

artículo científico publicado el 17 de marzo de 2011

Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases

artículo científico publicado en 2021

Heterologous Biosynthesis of Fungal Indole Sesquiterpene Sespendole

artículo científico publicado en 2018

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

scientific article published on 01 December 2018

Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

artículo científico publicado en 2012

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

artículo científico publicado en 2006

Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. ⬇️

artículo científico publicado en 2009

Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali

artículo científico publicado en 2008

Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.

artículo científico publicado en 2018

Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus

artículo científico publicado en 2013

Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture

artículo científico publicado en 2008

Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

artículo científico publicado en 2003

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

artículo científico publicado en 2010

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

artículo científico publicado en 2010

Molecular cloning and characterization of a cDNA encoding ent-cassa-12,15-diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension-cultured rice cells treated with a chitin elicitor

artículo científico publicado en 2004

Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin

artículo científico publicado en 2020

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

artículo científico publicado en 2012

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

artículo científico

Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

artículo científico publicado en 2020

Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene.

artículo científico publicado en 2005

Proposed mechanism for the reaction catalyzed by a diterpene cyclase, aphidicolan-16beta-ol synthase: experimental results on biomimetic cyclization and examination of the cyclization pathway by ab initio calculations

scientific article published on 01 August 2002

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

artículo científico publicado en 2009

Recent advances of Diels-Alderases involved in natural product biosynthesis

artículo científico publicado en 2016

Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline in Aspergillus oryzae ⬇️

artículo científico publicado el 15 de enero de 2013

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem

article published in 2015

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host

artículo científico publicado en 2015

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

artículo científico publicado en 2010

Relative and absolute configuration of antitumor agent SW-163D.

artículo científico publicado en 2007

Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.

artículo científico publicado en 2006

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

artículo científico publicado en 2012

Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D

artículo científico publicado en 2009

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani

artículo científico publicado en 2010

Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis

artículo científico publicado en 2017

Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents

artículo científico publicado en 2017

Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation

artículo científico publicado en 2012

Structure of macrophomate synthase.

artículo científico publicado en 2004

Studies on the later stage of the biosynthesis of pleuromutilin

artículo científico publicado en 2007

The relative and absolute configuration of PF1140.

artículo científico publicado en 2005

Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification

artículo científico publicado en 2018

Total biosynthesis of antiangiogenic agent (-)-terpestacin by artificial reconstitution of the biosynthetic machinery in Aspergillus oryzae

artículo científico publicado en 2018

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

artículo científico publicado en 2006

Total synthesis of (+/-)-syn-copalol

artículo científico publicado en 2002

Total synthesis of alkaloids using both chemical and biochemical methods

scientific article published on 06 March 2020

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

artículo científico publicado en 2008

Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase

artículo científico publicado en 2018

Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds

scientific article published on 01 May 2019

Lista de obras de

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis

An anti-tetraamination of a 1,3-diene unit via cascade annulations of the azulenone scaffold with dicarbonyl azo-compounds

An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation ⬇️

Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis

Biosynthesis of indole diterpenes, emindole, and paxilline: involvement of a common intermediate

Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene

Biosynthetic Machinery of 6-Hydroxymellein Derivatives Leading to Cyclohelminthols and Palmaenones

Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.

Biosynthetic gene-based secondary metabolite screening: a new diterpene, methyl phomopsenonate, from the fungus Phomopsis amygdali.

Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part

Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase

Characterization of a rice gene family encoding type-A diterpene cyclases

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes

Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants

Design and De Novo Synthesis of 6-Aza-artemisinins

Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice ⬇️

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

Efficient Reconstitution of Basidiomycota Diterpene Erinacine Gene Cluster in Ascomycota Host Aspergillus oryzae Based on Genomic DNA Sequences

Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi

Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product ⬇️

Expression of Alternaria solani PKSF generates a set of complex reduced-type polyketides with different carbon-lengths and cyclization

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products

Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster ⬇️

Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues ⬇️

Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases

Heterologous Biosynthesis of Fungal Indole Sesquiterpene Sespendole

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. ⬇️

Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali

Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.

Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus

Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture

Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

Molecular cloning and characterization of a cDNA encoding ent-cassa-12,15-diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension-cultured rice cells treated with a chitin elicitor

Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene.

Proposed mechanism for the reaction catalyzed by a diterpene cyclase, aphidicolan-16beta-ol synthase: experimental results on biomimetic cyclization and examination of the cyclization pathway by ab initio calculations

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Recent advances of Diels-Alderases involved in natural product biosynthesis

Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline in Aspergillus oryzae ⬇️

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

Relative and absolute configuration of antitumor agent SW-163D.

Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani

Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis

Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents

Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation

Structure of macrophomate synthase.

Studies on the later stage of the biosynthesis of pleuromutilin

The relative and absolute configuration of PF1140.

Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification

Total biosynthesis of antiangiogenic agent (-)-terpestacin by artificial reconstitution of the biosynthetic machinery in Aspergillus oryzae

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

Total synthesis of (+/-)-syn-copalol

Total synthesis of alkaloids using both chemical and biochemical methods