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A case-based reasoning system for genotypic prediction of HIV-1 co-receptor tropism

artículo científico publicado en 2013

A decade of HIV-1 drug resistance in the United States: trends and characteristics in a large protease/reverse transcriptase and co-receptor tropism database from 2003 to 2012.

artículo científico publicado en 2014

A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein

artículo científico publicado en 2011

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

artículo científico publicado en 2003

A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue

artículo científico publicado en 2009

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

article

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

artículo científico publicado en 2003

Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection

artículo científico publicado en 2007

Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease

artículo científico publicado en 2002

Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication

artículo científico publicado en 2003

Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity

artículo científico publicado en 2002

Analysis of HIV-1 subtype B third variable region peptide motifs for induction of neutralizing antibodies against HIV-1 primary isolates

artículo científico publicado en 2005

Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens

artículo científico publicado el 28 de junio de 2010

Ancestral sequences from an elite neutralizer proximal to the development of neutralization resistance as a potential source of HIV vaccine immunogens

article

Assessing chemokine co-receptor usage in HIV

artículo científico publicado en 2005

Assessing predicted HIV-1 replicative capacity in a clinical setting

artículo científico publicado en 2011

Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women

artículo científico publicado en 2006

Baseline HIV type 1 coreceptor tropism predicts disease progression

artículo científico publicado en 2007

Broad Nucleoside Reverse‐Transcriptase Inhibitor Cross‐Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates

artículo científico publicado el 16 de septiembre de 2003

Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope

artículo científico publicado en 2009

CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy

artículo científico publicado en 2002

Cerebrospinal fluid HIV infection and pleocytosis: relation to systemic infection and antiretroviral treatment

artículo científico publicado en 2005

Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors

artículo científico publicado en 2004

Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B.

artículo científico publicado en 2005

Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals

artículo científico publicado en 2009

Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus

artículo científico publicado en 2003

Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance

artículo científico publicado en 2010

Comparison of human immunodeficiency virus type 1 tropism profiles in clinical samples by the Trofile and MT-2 assays

artículo científico publicado en 2009

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

artículo científico publicado en 2004

Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens

artículo científico publicado el 4 de abril de 2011

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

artículo científico publicado en 2006

Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein

artículo científico publicado en 2008

Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations.

artículo científico publicado en 2007

Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing

artículo científico publicado en 2011

Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism

artículo científico publicado en 2006

Development of an HIV-1 reference panel of subtype B envelope clones isolated from the plasma of recently infected individuals

artículo científico publicado en 2007

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

artículo científico publicado en 2010

Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors

artículo científico publicado en 2010

Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein

artículo científico publicado en 2009

Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain

artículo científico publicado en 2015

Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1

artículo científico publicado en 2016

Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.

artículo científico publicado en 2012

Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy

artículo científico publicado en 2010

Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults

artículo científico publicado en 2002

Exploring the complexity of the HIV-1 fitness landscape

artículo científico publicado en 2012

Five Antiretroviral Drug Class-Resistant HIV-1 in a Treatment-Naïve Patient Successfully Suppressed with Optimized Antiretroviral Drug Selection

artículo científico publicado en 2015

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

artículo científico publicado en 2008

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer

artículo científico publicado en 2013

HIV drug resistance acquired through superinfection

artículo científico publicado en 2005

HIV evolution and escape.

artículo científico publicado en 2004

HIV-1 chemokine coreceptor utilization in paired cerebrospinal fluid and plasma samples: a survey of subjects with viremia

artículo científico publicado en 2005

Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection

artículo científico publicado en 2004

Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains

artículo científico publicado en 2005

Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates

artículo científico publicado en 2002

Identification of a transmission chain of HIV type 1 containing drug resistance-associated mutations

artículo científico publicado en 2003

Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption

artículo científico publicado en 2010

Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance

artículo científico publicado en 2003

In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine

artículo científico publicado en 2008

Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report

artículo científico publicado en 2005

Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection

artículo científico publicado en 2005

Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure

artículo científico publicado en 2009

Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab

artículo científico publicado el 2 de febrero de 2011

Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways

artículo científico publicado en 2009

Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies

artículo científico publicado en 2007

Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease

artículo científico publicado en 2018

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

artículo científico publicado en 2002

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations

artículo científico

Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir

artículo científico publicado en 2013

Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1.

artículo científico publicado en 2010

Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.

artículo científico publicado en 2004

Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses

artículo científico publicado en 2006

Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection

artículo científico publicado en 2005

Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data

artículo científico publicado en 2012

Persistence of drug-resistant HIV-1 after a structured treatment interruption and its impact on treatment response

artículo científico publicado en 2003

Persistence of primary drug resistance among recently HIV-1 infected adults

artículo científico publicado en 2004

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds

artículo científico publicado en 2015

Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

artículo científico publicado en 2008

Phenotypic and genotypic HIV-1 drug resistance assays provide complementary information

artículo científico publicado en 2002

Phenotypic drug resistance patterns in subtype A HIV-1 clones with nonnucleoside reverse transcriptase resistance mutations

artículo científico publicado en 2006

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1.

artículo científico publicado en 2005

Practical applications of viral fitness in clinical practice

artículo científico publicado en 2003

Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method

artículo científico publicado en 2014

Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

artículo científico publicado en 2017

Principal component analysis of general patterns of HIV-1 replicative fitness in different drug environments.

artículo científico publicado en 2010

Quantitation of HER2 expression or HER2:HER2 dimers and differential survival in a cohort of metastatic breast cancer patients carefully selected for trastuzumab treatment primarily by FISH.

artículo científico publicado en 2009

Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1

artículo científico publicado en 2014

Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines

artículo científico publicado en 2005

Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasma

artículo científico publicado en 2003

Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors

artículo científico publicado en 2013

Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions

artículo científico publicado en 2002

Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.

artículo científico publicado en 2004

Substitutions at Amino Acid Positions 143, 148, and 155 of HIV-1 Integrase Define Distinct Genetic Barriers to Raltegravir Resistance In Vivo

artículo científico publicado el 2 de mayo de 2012

Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition

artículo científico publicado en 2008

The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors

artículo científico publicado en 2006

The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment

artículo científico publicado el 4 de octubre de 2011

The probable source of both the primary multidrug-resistant (MDR) HIV-1 strain found in a patient with rapid progression to AIDS and a second recombinant MDR strain found in a chronically HIV-1-infected patient

artículo científico publicado en 2007

Time trends in primary HIV-1 drug resistance among recently infected persons

artículo científico publicado en 2002

Transmission of Integrase Strand-Transfer Inhibitor Multidrug-Resistant HIV-1: Case Report and Response to Raltegravir-Containing Antiretroviral Therapy

artículo científico publicado el 1 de enero de 2011

Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542.

artículo científico publicado en 2004

Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother-infant pairs.

artículo científico publicado en 2009

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

artículo científico publicado en 2013