Lista de obras -

'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites

artículo científico publicado en 2016

'Unknown' proteins and 'orphan' enzymes: the missing half of the engineering parts list--and how to find it

artículo científico publicado en 2009

6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria

scientific article published on 24 April 2009

7-Deazaguanine modifications protect phage DNA from host restriction systems

scientific article published on 29 November 2019

A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism.

artículo científico publicado en 2011

A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes.

artículo científico publicado en 2009

A genetic investigation of the KEOPS complex in halophilic Archaea

artículo científico publicado en 2012

A network approach to elucidate and prioritize microbial dark matter in microbial communities

artículo científico publicado en 2020

A plastidial pantoate transporter with a potential role in pantothenate synthesis

artículo científico publicado en 2018

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.

artículo científico publicado en 2010

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

artículo científico publicado en 2011

A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis

artículo científico publicado en 2017

A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life

artículo científico publicado en 2009

Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering

scientific article published on 28 October 2004

Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code?

artículo científico publicado en 2004

Bacterial and plant HAD enzymes catalyse a missing phosphatase step in thiamin diphosphate biosynthesis

artículo científico publicado en 2015

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages

artículo científico publicado en 2024

Biosynthesis and function of posttranscriptional modifications of transfer RNAs

artículo científico

Biosynthesis and function of tRNA modifications in Archaea

scientific article published on 04 April 2011

Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I

artículo científico publicado en 2008

Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside

scientific journal article

Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea

artículo científico publicado en 2010

Can Protein Expression Be Regulated by Modulation of tRNA Modification Profiles?

scientific article published on 18 December 2018

Comparative RNomics and modomics in Mollicutes: prediction of gene function and evolutionary implications

scientific article published on 01 October 2007

Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage

artículo científico publicado en 2012

Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate

artículo científico publicado en 2012

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

artículo científico publicado en 2007

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme

artículo científico publicado en 2005

Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.

artículo científico publicado en 2016

Deciphering synonymous codons in the three domains of life: co-evolution with specific tRNA modification enzymes

scientific article published on January 2010

Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors

artículo científico publicado en 2024

Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.

artículo científico publicado en 2016

Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?

artículo científico publicado en 2012

Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA

artículo científico publicado en 2010

Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs

artículo científico publicado en 2005

Discovery of a new prokaryotic type I GTP cyclohydrolase family

artículo científico publicado en 2006

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight

artículo científico publicado en 2017

Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs

scientific journal article

Diversity of archaeosine synthesis in crenarchaeota

artículo científico publicado en 2011

Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA

artículo científico publicado en 2014

Epoxyqueuosine Reductase QueH in the Biosynthetic Pathway to tRNA Queuosine Is a Unique Metalloenzyme

artículo científico publicado en 2021

Erratum to “Towards a Systems Approach in the Genetic Analysis of Archaea: Accelerating Mutant Construction and Phenotypic Analysis in Haloferax volcanii”.

artículo científico publicado en 2011

Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria

artículo científico publicado en 2015

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

artículo científico publicado en 2018

Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family

scientific article published in 2022

Experimental Evolution of a Facultative Thermophile from a Mesophilic Ancestor ⬇️

artículo científico publicado el 21 de octubre de 2011

Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB).

artículo científico publicado en 2016

Finding novel metabolic genes through plant-prokaryote phylogenomics

artículo científico publicado en 2007

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa

scientific journal article

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold

artículo científico publicado en 2005

Functional Annotations of Paralogs: A Blessing and a Curse

artículo científico publicado en 2016

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

artículo científico publicado en 2015

Functional promiscuity of the COG0720 family

artículo científico publicado en 2011

Functional redundancy in tRNA dihydrouridylation

artículo científico publicado en 2024

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

artículo científico publicado en 2011

Gene Graphics: a genomic neighborhood data visualization web application

artículo científico publicado en 2017

Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi

artículo científico publicado en 2007

Genome sequence of Candidatus Riesia pediculischaeffi, endosymbiont of chimpanzee lice, and genomic comparison of recently acquired endosymbionts from human and chimpanzee lice

artículo científico publicado en 2014

Genomics-driven reconstruction of acinetobacter NAD metabolism: insights for antibacterial target selection

artículo científico publicado en 2010

Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway

artículo científico publicado en 2012

Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics

artículo científico publicado en 2017

Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine

artículo científico publicado en 2004

Identification of genes encoding tRNA modification enzymes by comparative genomics

artículo científico publicado en 2007

Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery

scientific article published on 12 October 2018

Identification of the tRNA-dihydrouridine synthase family.

artículo científico publicado en 2002

Identification of the thiamin salvage enzyme thiazole kinase in Arabidopsis and maize

artículo científico publicado en 2013

Incorporation of nonnatural amino acids into proteins

artículo científico publicado en 2004

Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase

artículo científico publicado en 2005

Inhibition of mutation and combating the evolution of antibiotic resistance

artículo científico publicado en 2005

Integrative data-mining tools to link gene and function

artículo científico publicado en 2014

Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of Escherichia coli ⬇️

artículo científico publicado el 20 de noviembre de 2001

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

artículo científico publicado en 2020

MODOMICS: a database of RNA modification pathways. 2017 update

artículo científico publicado en 2017

Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress

artículo científico publicado en 2014

Matching tRNA modifications in humans to their known and predicted enzymes

artículo científico publicado en 2019

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

artículo científico publicado en 2016

Metabolite Damage and Metabolite Damage Control in Plants

artículo científico publicado en 2016

Mining high-throughput experimental data to link gene and function

artículo científico publicado en 2011

Molecular determinants of dihydrouridine synthase activity

artículo científico publicado en 2006

Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase

artículo científico publicado en 2010

Mutational separation of two pathways for editing by a class I tRNA synthetase.

artículo científico publicado en 2002

Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy

artículo científico publicado en 2016

PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

artículo científico publicado en 2019

Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.

artículo científico publicado en 2008

Plant B vitamin pathways and their compartmentation: a guide for the perplexed

artículo científico

Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family

artículo científico publicado en 2014

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

artículo científico publicado en 2008

Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species

artículo científico publicado en 2010

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species

artículo científico publicado en 2014

Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii

artículo científico publicado en 2011

Quantitative mapping of the cellular small RNA landscape with AQRNA-seq

artículo científico publicado en 2021

QueF-Like, a Non-Homologous Archaeosine Synthase from the Crenarchaeota

artículo científico publicado en 2017

Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci

artículo científico publicado en 2012

RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes

artículo científico publicado en 2008

Rapid evolution of diminished transformability in Acinetobacter baylyi

artículo científico publicado en 2006

Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

scientific article published on 10 April 2020

Role of a Zn-independent DksA in Zn homeostasis and stringent response

scientific journal article

Structural Basis of Biological Nitrile Reduction

artículo científico publicado en 2012

Synergistic use of plant-prokaryote comparative genomics for functional annotations

artículo científico publicado en 2011

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes

artículo científico publicado en 2015

The COMBREX project: design, methodology, and initial results

artículo científico publicado en 2013

The DUF328 family member YaaA is a DNA-binding protein with a novel fold

scientific article published on 12 August 2020

The Escherichia coli COG1738 Member YhhQ Is Involved in 7-Cyanodeazaguanine (preQ₀) Transport

artículo científico publicado en 2017

The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth

artículo científico publicado en 2015

The absence of the Queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in <i>Escherichia coli</i> K12

artículo científico publicado en 2022

The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA.

artículo científico publicado en 2012

The emerging role of complex modifications of tRNA(Lys)UUU in signaling pathways

artículo científico publicado en 2015

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes

artículo científico publicado en 2005

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

artículo científico publicado en 2009

Towards a systems approach in the genetic analysis of archaea: Accelerating mutant construction and phenotypic analysis in Haloferax volcanii

artículo científico publicado en 2010

Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex

artículo científico publicado en 2020

Variations in metabolic pathways create challenges for automated metabolic reconstructions: Examples from the tetrahydrofolate synthesis pathway

artículo científico publicado en 2014

YeiR: a metal-binding GTPase from Escherichia coli involved in metal homeostasis

artículo científico publicado en 2012

Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

artículo científico publicado en 2009

tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy

artículo científico publicado en 2017

tRNAmodpred: A computational method for predicting posttranscriptional modifications in tRNAs

artículo científico publicado en 2016

Lista de obras de

'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites

'Unknown' proteins and 'orphan' enzymes: the missing half of the engineering parts list--and how to find it

6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria

7-Deazaguanine modifications protect phage DNA from host restriction systems

A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism.

A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes.

A genetic investigation of the KEOPS complex in halophilic Archaea

A network approach to elucidate and prioritize microbial dark matter in microbial communities

A plastidial pantoate transporter with a potential role in pantothenate synthesis

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis

A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life

Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering

Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code?

Bacterial and plant HAD enzymes catalyse a missing phosphatase step in thiamin diphosphate biosynthesis

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages

Biosynthesis and function of posttranscriptional modifications of transfer RNAs

Biosynthesis and function of tRNA modifications in Archaea

Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I

Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside

Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea

Can Protein Expression Be Regulated by Modulation of tRNA Modification Profiles?

Comparative RNomics and modomics in Mollicutes: prediction of gene function and evolutionary implications

Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage

Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme

Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.

Deciphering synonymous codons in the three domains of life: co-evolution with specific tRNA modification enzymes

Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors

Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.

Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?

Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA

Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs

Discovery of a new prokaryotic type I GTP cyclohydrolase family

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight

Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs

Diversity of archaeosine synthesis in crenarchaeota

Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA

Epoxyqueuosine Reductase QueH in the Biosynthetic Pathway to tRNA Queuosine Is a Unique Metalloenzyme

Erratum to “Towards a Systems Approach in the Genetic Analysis of Archaea: Accelerating Mutant Construction and Phenotypic Analysis in Haloferax volcanii”.

Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family

Experimental Evolution of a Facultative Thermophile from a Mesophilic Ancestor ⬇️

Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB).

Finding novel metabolic genes through plant-prokaryote phylogenomics

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold

Functional Annotations of Paralogs: A Blessing and a Curse

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

Functional promiscuity of the COG0720 family

Functional redundancy in tRNA dihydrouridylation

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

Gene Graphics: a genomic neighborhood data visualization web application

Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi

Genome sequence of Candidatus Riesia pediculischaeffi, endosymbiont of chimpanzee lice, and genomic comparison of recently acquired endosymbionts from human and chimpanzee lice

Genomics-driven reconstruction of acinetobacter NAD metabolism: insights for antibacterial target selection

Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway

Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics

Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine

Identification of genes encoding tRNA modification enzymes by comparative genomics

Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery

Identification of the tRNA-dihydrouridine synthase family.

Identification of the thiamin salvage enzyme thiazole kinase in Arabidopsis and maize

Incorporation of nonnatural amino acids into proteins

Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase

Inhibition of mutation and combating the evolution of antibiotic resistance

Integrative data-mining tools to link gene and function

Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of Escherichia coli ⬇️

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

MODOMICS: a database of RNA modification pathways. 2017 update

Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress

Matching tRNA modifications in humans to their known and predicted enzymes

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

Metabolite Damage and Metabolite Damage Control in Plants

Mining high-throughput experimental data to link gene and function

Molecular determinants of dihydrouridine synthase activity