Lista de obras -

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control

artículo científico publicado en 2010

A Role for Hepatic Leptin Signaling in Lipid Metabolism via Altered Very Low Density Lipoprotein Composition and Liver Lipase Activity in Mice ⬇️

artículo científico publicado el 6 de diciembre de 2012

A human embryonic stem cell line adapted for high throughput screening

artículo científico publicado en 2013

A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression

artículo científico publicado en 2010

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice

artículo científico publicado en 2007

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

artículo científico publicado en 2015

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway

artículo científico publicado en 2009

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

artículo científico publicado en 2017

Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway

artículo científico publicado en 2010

Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

scientific article published on 19 January 2017

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice

artículo científico publicado en 2012

Cellular reprogramming of human amniotic fluid cells to express insulin

artículo científico publicado en 2010

Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species

artículo científico publicado en 2015

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation

artículo científico publicado en 2009

Clinical application of glucagon-like Peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus

scientific article published on December 2013

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

artículo científico publicado en 2004

Closing in on Mass Production of Mature Human Beta Cells

artículo científico publicado en 2016

Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women

artículo científico publicado en 2004

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.

artículo científico publicado en 2010

Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

artículo científico

Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

artículo científico publicado en 2016

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

artículo científico publicado en 2016

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance ⬇️

artículo científico publicado el 28 de septiembre de 2010

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation

artículo científico publicado en 2017

Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1 ⬇️

artículo científico publicado el 8 de febrero de 2011

Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice

artículo científico publicado en 2009

Engineering the gut for insulin replacement to treat diabetes

artículo científico publicado en 2016

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently

artículo científico publicado en 2004

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

artículo científico publicado en 2013

GIP or not GIP? That is the question

artículo científico publicado en 2003

Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents

artículo científico publicado en 2005

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

artículo científico publicado en 2016

Glucagon-like peptide-1: glucose homeostasis and beyond

artículo científico publicado en 2013

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

artículo científico publicado en 2015

Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.

artículo científico publicado en 2005

Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion

artículo científico publicado en 2010

Harnessing the gut to treat diabetes

artículo científico publicado en 2004

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

artículo científico publicado en 2016

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

artículo científico publicado en 2012

Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling

artículo científico publicado en 2010

Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice

artículo científico publicado en 2016

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice

artículo científico publicado en 2014

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination

artículo científico publicado en 2013

Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes

artículo científico publicado en 2013

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice

artículo científico publicado en 2012

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

artículo científico publicado en 2006

In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and Motilin

artículo científico publicado en 2017

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes ⬇️

artículo científico publicado el 14 de septiembre de 2010

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

artículo científico publicado en 2008

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

artículo científico publicado en 2005

Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells

artículo científico publicado en 2013

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy

artículo científico publicado en 2015

Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation

artículo científico publicado en 2017

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes

Insulin-expressing engineered cell lines and primary cells: surrogate β cells from liver, gut, and other sources

artículo científico publicado en 2007

Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques ⬇️

artículo científico publicado el 18 de enero de 2013

K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease

artículo científico publicado el 1 de enero de 2010

Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis

artículo científico publicado en 2010

Leptin administration enhances islet transplant performance in diabetic mice

artículo científico publicado en 2013

Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

article

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis

artículo científico

Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats

artículo científico publicado en 2008

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression

artículo científico publicado en 2004

Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol

artículo científico publicado en 2015

Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.

artículo científico publicado en 2011

Link between GIP and osteopontin in adipose tissue and insulin resistance

artículo científico publicado en 2013

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

artículo científico publicado en 2017

Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling - two markers of addiction vulnerability

artículo científico publicado en 2015

Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology

artículo científico publicado en 2012

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

artículo científico publicado en 2013

Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice

artículo científico publicado en 2012

Metabolic effects of chronic obestatin infusion in rats

artículo científico publicado en 2008

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues

article published in 2019

Mining incretin hormone pathways for novel therapies

artículo científico publicado en 2009

Ontogeny of Ghrelin, Obestatin, Preproghrelin, and Prohormone Convertases in Rat Pancreas and Stomach

scientific article published on 01 January 2009

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

artículo científico publicado en 2014

Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation

artículo científico publicado en 2011

Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

artículo científico publicado en 2015

Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis

artículo científico publicado en 2014

Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells

artículo científico publicado en 2008

Pleiotropic effects of GIP on islet function involve osteopontin

artículo científico publicado en 2011

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

artículo científico publicado en 2011

Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells

artículo científico publicado en 2015

Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells ⬇️

artículo científico publicado el 22 de octubre de 2010

Profiling of circulating microRNAs in children with recent onset of type 1 diabetes

artículo científico publicado en 2017

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

artículo científico publicado en 2015

Regenerative medicine and cell-based approaches to restore pancreatic function

artículo científico publicado en 2017

Regulation of somatostatin release by adenosine in the mouse stomach

artículo científico publicado en 2009

Replacing and safeguarding pancreatic β cells for diabetes

artículo científico publicado en 2015

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia

artículo científico publicado en 2017

Restoring insulin production for type 1 diabetes.

artículo científico

Reversal of diabetes by βTC3 cells encapsulated in alginate beads generated by emulsion and internal gelation

artículo científico publicado en 2012

Sex differences in maturation of human embryonic stem cell-derived beta cells in mice

artículo científico publicado en 2018

Statistical approaches and software for clustering islet cell functional heterogeneity

artículo científico publicado en 2016

Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep(ob/ob) mice

artículo científico publicado en 2016

Targeting the glucagon receptor family for diabetes and obesity therapy ⬇️

artículo científico publicado el 1 de junio de 2012

The Role of ARX in Human Pancreatic Endocrine Specification

artículo científico publicado en 2015

The glucoregulatory actions of leptin

artículo científico publicado en 2017

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis

artículo científico publicado en 2006

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

artículo científico publicado en 2016

The role of leptin in glucose homeostasis

artículo científico publicado en 2012

Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice

artículo científico publicado en 2008

Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs

artículo científico publicado en 2015

Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells.

artículo científico publicado en 2009

Treatment of diabetes with glucagon-like peptide-1 gene therapy ⬇️

artículo científico publicado el 28 de octubre de 2010

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin

artículo científico publicado en 2008

Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation

article

WITHDRAWN: Involvement of Adenosine Signaling in Controlling the Release of Ghrelin from the Mouse Stomach ⬇️

artículo científico publicado el 21 de enero de 2011

Lista de obras de

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control

A Role for Hepatic Leptin Signaling in Lipid Metabolism via Altered Very Low Density Lipoprotein Composition and Liver Lipase Activity in Mice ⬇️

A human embryonic stem cell line adapted for high throughput screening

A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway

Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice

Cellular reprogramming of human amniotic fluid cells to express insulin

Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation

Clinical application of glucagon-like Peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

Closing in on Mass Production of Mature Human Beta Cells

Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.

Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance ⬇️

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation

Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1 ⬇️

Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice

Engineering the gut for insulin replacement to treat diabetes

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

GIP or not GIP? That is the question

Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

Glucagon-like peptide-1: glucose homeostasis and beyond

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.

Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion

Harnessing the gut to treat diabetes

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling

Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination

Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and Motilin

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes ⬇️

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy

Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes

Insulin-expressing engineered cell lines and primary cells: surrogate β cells from liver, gut, and other sources

Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques ⬇️

K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease

Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis

Leptin administration enhances islet transplant performance in diabetic mice

Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis

Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression

Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol

Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.

Link between GIP and osteopontin in adipose tissue and insulin resistance

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling - two markers of addiction vulnerability

Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice

Metabolic effects of chronic obestatin infusion in rats

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues

Mining incretin hormone pathways for novel therapies

Ontogeny of Ghrelin, Obestatin, Preproghrelin, and Prohormone Convertases in Rat Pancreas and Stomach

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation

Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis