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8OHdG as a marker for Huntington disease progression

artículo científico publicado en 2012

8OHdG is not a biomarker for Huntington disease state or progression

artículo científico publicado en 2013

A Computational Cognitive Biomarker for Early-Stage Huntington's Disease

artículo científico publicado en 2016

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

artículo científico publicado en 2015

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers

artículo científico publicado en 2015

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

artículo científico publicado en 2008

A systematic review and meta-analysis of clinical variables used in Huntington disease research

artículo científico

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

artículo científico publicado en 2005

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2009

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2013

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2011

Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease

Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study

article published in 2018

Aquatherapy for neurodegenerative disorders

artículo científico publicado en 2014

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

artículo científico publicado en 2010

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

artículo científico publicado en 2009

Body weight is modulated by levels of full-length huntingtin

artículo científico publicado en 2006

Brain Regions Showing White Matter Loss in Huntington's Disease Are Enriched for Synaptic and Metabolic Genes

artículo científico publicado en 2017

Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease

artículo científico publicado en 2008

CAG-encoded polyglutamine length polymorphism in the human genome

artículo científico publicado en 2007

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

artículo científico publicado en 2002

Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease

scientific article published on 25 June 2016

Chapter 15 Juvenile amyotrophic lateral sclerosis

artículo científico publicado en 2007

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

artículo científico publicado en 2006

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy

artículo científico publicado en 2011

Clinical utility gene card for: Huntington's disease

artículo científico publicado en 2013

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

artículo científico publicado en 2015

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

artículo científico publicado en 2007

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

artículo científico publicado en 2015

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

artículo científico publicado en 2017

Corpus callosal atrophy in premanifest and early Huntington's disease

artículo científico publicado en 2013

Correction of inter-scanner and within-subject variance in structural MRI based automated diagnosing

artículo científico publicado en 2014

Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease.

artículo científico publicado en 2017

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

artículo científico publicado en 2005

Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice

artículo científico publicado en 2011

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

artículo científico publicado en 2005

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons

artículo científico publicado en 2012

Depletion of wild-type huntingtin in mouse models of neurologic diseases

artículo científico publicado en 2003

Design optimization for clinical trials in early-stage manifest Huntington's disease

artículo científico publicado en 2017

Detection of Motor Changes in Huntington's Disease Using Dynamic Causal Modeling

artículo científico publicado en 2015

Development of biomarkers for Huntington's disease

artículo científico publicado en 2011

Diagnostic criteria for Huntington's disease based on natural history

artículo científico publicado en 2014

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

artículo científico publicado en 2009

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

artículo científico

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

artículo científico publicado en 2002

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial

artículo científico

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

artículo científico publicado en 2005

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

scientific journal article

Epidemiology of Huntington disease

artículo científico publicado en 2017

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

artículo científico publicado en 2005

Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease.

artículo científico publicado en 2012

Expression analysis of novel striatal-enriched genes in Huntington disease

artículo científico publicado en 2009

Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease

artículo científico publicado en 2006

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease

artículo científico publicado en 2012

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development

artículo científico

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

artículo científico publicado en 2010

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

artículo científico publicado en 2009

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

artículo científico publicado en 2002

Huntingtin inhibits caspase-3 activation

scientific journal article

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

artículo científico publicado en 2003

Huntingtin proteolysis in Huntington disease

Huntington disease

Huntington disease: natural history, biomarkers and prospects for therapeutics

artículo científico publicado en 2014

Huntington's disease: a field on the move. Introduction

artículo científico publicado en 2014

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

artículo científico

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

artículo científico publicado en 2002

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

artículo científico publicado en 2002

Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease

artículo científico publicado en 2015

Introducing the "Clinical Trials Corner".

artículo científico publicado en 2017

Iron dysregulation in Huntington's disease

artículo científico publicado en 2014

Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?

scientific article published on 01 October 2006

Journal of Huntington's Disease

artículo científico publicado en 2012

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

artículo científico publicado en 2017

Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance

artículo científico publicado en 2015

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

artículo científico publicado en 2005

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

artículo científico publicado en 2004

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2005

Medication Use in Early-HD Participants in Track-HD: an Investigation of its Effects on Clinical Performance

artículo científico publicado en 2016

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

artículo científico publicado en 2017

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

artículo científico publicado en 2007

Natural biological variation of white matter microstructure is accentuated in Huntington's disease.

artículo científico publicado en 2018

Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease

artículo científico publicado en 2016

Neurobiology of Huntington's Disease

artículo científico

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

artículo científico publicado en 2017

Neurofilament light protein in blood predicts regional atrophy in Huntington disease

artículo científico publicado en 2018

Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment

artículo científico publicado en 2016

Operationalizing compensation over time in neurodegenerative disease

scientific article published on 23 February 2017

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

artículo científico publicado en 2006

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

artículo científico publicado en 2010

Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model

artículo científico publicado en 2013

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

artículo científico publicado en 2011

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

artículo científico publicado en 2004

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

artículo científico publicado en 2013

Progranulin in neurodegenerative disease

artículo científico

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus

artículo científico publicado en 2013

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

artículo científico publicado en 2015

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

artículo científico publicado en 2007

Quality of life in Huntington's disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners

artículo científico publicado en 2013

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

artículo científico publicado en 2015

Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats

artículo científico publicado en 2008

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease

artículo científico publicado en 2017

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

artículo científico publicado en 2002

Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies

artículo científico publicado en 2015

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

artículo científico publicado en 2003

Satellog: a database for the identification and prioritization of satellite repeats in disease association studies.

artículo científico publicado en 2005

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2005

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

artículo científico publicado en 2017

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

artículo científico publicado en 2003

Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice

artículo científico publicado en 2013

Striatal neurochemical changes in transgenic models of Huntington's disease

artículo científico publicado en 2002

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

artículo científico publicado en 2005

Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease

artículo científico publicado en 2017

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis

artículo científico publicado en 2017

Synaptic dysfunction in progranulin-deficient mice

artículo científico publicado en 2011

Testicular degeneration in Huntington disease.

artículo científico publicado en 2007

Testing a longitudinal compensation model in premanifest Huntington's disease

Tetrabenazine

artículo científico publicado en 2009

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)

artículo científico publicado en 2013

The clinical and genetic features of Huntington disease

artículo científico publicado en 2010

The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease

artículo científico publicado en 2015

The potential of composite cognitive scores for tracking progression in Huntington's disease

artículo científico publicado en 2014

The structural involvement of the cingulate cortex in premanifest and early Huntington's disease

artículo científico publicado en 2011

Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington's disease

artículo científico publicado en 2017

Transcriptional Regulation of the Huntingtin Gene

article

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

artículo científico publicado en 2010

Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole

artículo científico publicado en 2015

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease

artículo científico publicado en 2005

Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay

artículo científico publicado en 2017

Visual Working Memory Impairment in Premanifest Gene-Carriers and Early Huntington's Disease

artículo científico publicado en 2012

Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease

artículo científico publicado en 2016

We are pleased to introduce this next volume of the Journal of Huntington's Disease. Introduction

artículo científico publicado en 2013

White matter predicts functional connectivity in premanifest Huntington's disease

artículo científico publicado en 2017

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

artículo científico publicado en 2006

Wild-type huntingtin protects neurons from excitotoxicity

artículo científico publicado en 2006

YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth

artículo científico publicado en 2011

p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease

artículo científico publicado en 2017

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