Lista de obras -

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

artículo científico publicado en 2014

A neurosteroid analogue photolabeling reagent labels the colchicine‐binding site on tubulin: A mass spectrometric analysis ⬇️

artículo científico publicado el 1 de febrero de 2012

A propofol binding site on mammalian GABAA receptors identified by photolabeling

artículo científico publicado en 2013

Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

artículo científico publicado en 2016

An improved method for assay of carboxylating enzymes

artículo científico publicado el 1 de abril de 1975

Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites

scientific article published on 16 July 2020

Anesthetic Neurotoxicity: New Findings and Future Directions

artículo científico publicado en 2016

Anesthetic neurotoxicity--clinical implications of animal models.

artículo científico publicado en 2015

Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

artículo científico publicado en 2012

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

artículo científico publicado en 2017

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

scientific article published on 22 November 2018

Congratulations from the IARS!

scientific article published on 01 October 2011

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.

artículo científico publicado en 2018

Fluorine-19 NMR spin-spin relaxation (T2) method for characterizing volatile anesthetic binding to proteins. Analysis of isoflurane binding to serum albumin ⬇️

artículo científico publicado el 11 de agosto de 1992

High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors.

artículo científico publicado en 2018

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Increased risk of intraoperative awareness in patients with a history of awareness.

artículo científico publicado en 2013

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

artículo científico publicado en 2010

Leadership in postgraduate medical education

artículo científico publicado en 2010

Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness.

artículo científico publicado en 2009

Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.

artículo científico publicado en 2018

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

artículo científico publicado en 2016

Multiple functional neurosteroid binding sites on GABAA receptors

artículo científico publicado en 2019

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

scientific article published on 05 June 2019

Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

artículo científico publicado en 2015

Neurosteroid Analog Photolabeling of a Site in the Third Transmembrane Domain of the β3 Subunit of the GABAA Receptor ⬇️

artículo científico publicado el 30 de mayo de 2012

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

artículo científico publicado en 2010

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

artículo científico publicado en 2013

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

artículo científico publicado en 2017

Postoperative Cognitive Dysfunction: Overinterpretation of Data? ⬇️

artículo científico publicado el 1 de mayo de 2003

Postoperative cognitive decline: the unsubstantiated phenotype

artículo científico publicado en 2010

Protamine relaxes vascular smooth muscle by directly reducing cytosolic free calcium concentrations in small resistance arteries.

artículo científico publicado en 1996

Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the post-anesthesia care unit

artículo científico publicado en 2020

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

scientific article published on 21 September 2020

SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain

artículo científico publicado en 2018

The Fallacy of Persistent Postoperative Cognitive Decline.

artículo científico publicado en 2016

The GAS trial

artículo científico publicado en 2016

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

scientific article published on December 2009

The molecular determinants of neurosteroid binding in the GABA(A) receptor

scientific article published on 28 May 2019

The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors

artículo científico publicado en 2014

Lista de obras de

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

A neurosteroid analogue photolabeling reagent labels the colchicine‐binding site on tubulin: A mass spectrometric analysis ⬇️

A propofol binding site on mammalian GABAA receptors identified by photolabeling

Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

An improved method for assay of carboxylating enzymes

Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites

Anesthetic Neurotoxicity: New Findings and Future Directions

Anesthetic neurotoxicity--clinical implications of animal models.

Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

Congratulations from the IARS!

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.

Fluorine-19 NMR spin-spin relaxation (T2) method for characterizing volatile anesthetic binding to proteins. Analysis of isoflurane binding to serum albumin ⬇️

High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors.

In Reply

In reply

Increased risk of intraoperative awareness in patients with a history of awareness.

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Leadership in postgraduate medical education

Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness.

Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Multiple functional neurosteroid binding sites on GABAA receptors

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Neurosteroid Analog Photolabeling of a Site in the Third Transmembrane Domain of the β3 Subunit of the GABAA Receptor ⬇️

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

Postoperative Cognitive Dysfunction: Overinterpretation of Data? ⬇️

Postoperative cognitive decline: the unsubstantiated phenotype

Protamine relaxes vascular smooth muscle by directly reducing cytosolic free calcium concentrations in small resistance arteries.

Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the post-anesthesia care unit

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain

The Fallacy of Persistent Postoperative Cognitive Decline.

The GAS trial

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

The molecular determinants of neurosteroid binding in the GABA(A) receptor

The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors