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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

artículo científico publicado en 2011

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

artículo científico publicado en 2013

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

HER2 activating mutations are targets for colorectal cancer treatment

artículo científico publicado en 2015

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

artículo científico publicado en 2015

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

artículo científico publicado en 2012

Inhibition of Src impairs the growth of met-addicted gastric tumors.

artículo científico publicado en 2010

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

artículo científico publicado en 2014

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

artículo científico publicado en 2013

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours

scientific article published on 06 February 2019

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.

artículo científico publicado en 2012

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

scientific article published on 08 December 2009

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

artículo científico publicado en 2017

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