Lista de obras -

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease

scientific article published on 26 November 2019

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

artículo científico publicado en 2014

Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities

scientific article published on 04 December 2018

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

artículo científico publicado en 2016

Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies

artículo científico publicado en 2015

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

artículo científico publicado en 2018

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.

artículo científico publicado en 2018

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

artículo científico publicado en 2016

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease

artículo científico publicado en 2019

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines.

artículo científico publicado en 2014

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity

artículo científico publicado en 2020

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity

artículo científico publicado en 2012

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

artículo científico publicado en 2017

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

artículo científico publicado en 2021

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease

artículo científico publicado en 2020

New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer's Disease

artículo científico publicado en 2020

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease

artículo científico publicado en 2017

New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors

artículo científico publicado en 2020

New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis.

artículo científico publicado en 2013

Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies

artículo científico publicado en 2015

Novel carbamate derivatives as selective butyrylcholinesterase inhibitors.

artículo científico publicado en 2018

Pathological Subtrochanteric Femoral Fracture Due to Extensive Arterio-venous Malformation. A Case Study

artículo científico publicado en 2015

Risk assessment of accidental exposure of surgeons to blood during orthopedic surgery. Are we safe in surgical gloves?

artículo científico publicado en 2014

Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

scientific article published on 26 June 2019

Structure modeling of γ-aminobutyric acid transporters - Molecular basics of ligand selectivity

scientific article published on 03 May 2020

Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

artículo científico publicado en 2015

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment

artículo científico publicado en 2018

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment

artículo científico publicado en 2017

Therapeutic strategies for Alzheimer's disease in clinical trials.

artículo científico

[Tako-tsubo syndrome - a form of acute coronary syndrome or completely different clinical entity - a case report]

scientific article published on 01 January 2010

γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases

scientific article published on 30 April 2020

Lista de obras de

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines.

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease

New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer's Disease

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease

New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors

New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis.

Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies

Novel carbamate derivatives as selective butyrylcholinesterase inhibitors.

Pathological Subtrochanteric Femoral Fracture Due to Extensive Arterio-venous Malformation. A Case Study

Risk assessment of accidental exposure of surgeons to blood during orthopedic surgery. Are we safe in surgical gloves?

Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

Structure modeling of γ-aminobutyric acid transporters - Molecular basics of ligand selectivity

Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment

Therapeutic strategies for Alzheimer's disease in clinical trials.

[Tako-tsubo syndrome - a form of acute coronary syndrome or completely different clinical entity - a case report]

γ-Aminobutyric acid transporters as relevant biological target: Their function, structure, inhibitors and role in the therapy of different diseases