Filtros de búsqueda

Lista de obras de

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

artículo científico publicado en 2015

A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.

artículo científico publicado en 2004

APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

artículo científico publicado en 2002

APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder

artículo científico publicado en 2005

APP23 mice display working memory impairment in the plus-shaped water maze.

artículo científico publicado en 2006

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

artículo científico publicado en 2004

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

artículo científico publicado en 2009

Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.

artículo científico publicado en 2003

Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice.

artículo científico publicado en 2009

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

artículo científico publicado en 2003

Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.

artículo científico publicado en 2003

Aggressive male APP23 mice modeling behavioral alterations in dementia

artículo científico publicado en 2006

Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances

artículo científico publicado en 2004

Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model

artículo científico publicado en 2008

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease

artículo científico publicado en 2008

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification ⬇️

artículo científico publicado el 14 de julio de 2009

Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons

artículo científico publicado en 2003

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

artículo científico publicado en 2017

Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

artículo científico publicado en 2002

Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties

artículo científico publicado en 2015

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

artículo científico publicado en 2013

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

artículo científico publicado en 2015

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models

artículo científico publicado en 2005

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

scientific journal article

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis

artículo científico publicado en 2017

BACE inhibition-dependent repair of Alzheimer's pathophysiology

artículo científico publicado en 2017

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

artículo científico publicado en 2007

Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid

artículo científico publicado en 2011

Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice

artículo científico publicado en 2012

Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model

artículo científico publicado en 2005

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

artículo científico publicado en 2013

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

artículo científico publicado en 2011

Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances

scientific article published on 21 March 2008

Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein

artículo científico publicado en 2013

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

artículo científico publicado en 2002

Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

artículo científico publicado en 2008

Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease

artículo científico publicado en 2006

Compromised hemodynamic response in amyloid precursor protein transgenic mice.

artículo científico publicado en 2002

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

artículo científico publicado en 2012

Cystatin C modulates cerebral beta-amyloidosis

artículo científico publicado en 2007

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

artículo científico publicado en 2015

Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice

artículo científico publicado en 2014

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

artículo científico publicado en 2007

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

artículo científico publicado en 2003

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

artículo científico publicado en 2012

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides

artículo científico publicado en 2013

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.

artículo científico publicado en 2012

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

artículo científico publicado en 2010

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition

artículo científico publicado en 2008

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition

artículo científico publicado en 2009

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

artículo científico publicado en 2015

Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.

artículo científico publicado en 2008

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

artículo científico publicado en 2008

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

artículo científico publicado en 2006

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

artículo científico publicado en 2009

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

artículo científico publicado en 2002

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

artículo científico publicado en 2007

Extracellular amyloid formation and associated pathology in neural grafts

artículo científico publicado en 2003

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

artículo científico publicado en 2009

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.

artículo científico publicado en 2014

Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment

artículo científico publicado en 2010

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

artículo científico publicado en 2013

Highly potent intracellular membrane-associated Aβ seeds

artículo científico publicado en 2016

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

artículo científico publicado en 2014

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

artículo científico publicado en 2006

Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies

artículo científico publicado en 2008

Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype

artículo científico publicado en 2008

Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia

artículo científico publicado en 2016

In VivoPositron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders ⬇️

artículo científico publicado el 23 de marzo de 2011

In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe

artículo científico publicado en 2005

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models

artículo científico publicado en 2015

Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.

artículo científico publicado en 2008

Independent effects of intra- and extracellular Abeta on learning-related gene expression

artículo científico publicado en 2009

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.

artículo científico publicado en 2004

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

artículo científico publicado en 2007

Innate immune memory in the brain shapes neurological disease hallmarks

scientific article published in Nature

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

artículo científico publicado en 2005

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

artículo científico publicado en 2005

Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition

artículo científico publicado en 2004

Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.

artículo científico publicado en 2006

Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

artículo científico publicado en 2016

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

artículo científico publicado en 2007

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application

artículo científico publicado en 2010

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

artículo científico publicado en 2009

Magnetic resonance angiography and vascular corrosion casting as tools in biomedical research: application to transgenic mice modeling Alzheimer's disease

artículo científico publicado en 2004

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology

artículo científico publicado en 2011

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

artículo científico publicado en 2013

Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers

artículo científico publicado en 2009

Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry

artículo científico publicado en 2002

Mood and male sexual behaviour in the APP23 model of Alzheimer's disease

artículo científico publicado en 2007

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

artículo científico publicado en 2014

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

artículo científico publicado en 2005

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

artículo científico publicado en 2006

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

artículo científico publicado en 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

artículo científico publicado en 2016

Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis

artículo científico publicado en 2008

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta

artículo científico publicado en 2010

Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23).

artículo científico publicado en 2003

Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immuno

artículo científico publicado el 19 de enero de 2011

Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety

artículo científico publicado en 2006

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

artículo científico publicado en 2006

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice

artículo científico publicado en 2009

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

artículo científico publicado en 2010

Persistence of Aβ seeds in APP null mouse brain.

artículo científico publicado en 2015

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

artículo científico publicado en 2006

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

artículo científico publicado en 2016

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

artículo científico publicado en 2002

Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.

artículo científico publicado en 2008

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice

artículo científico publicado en 2010

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

artículo científico publicado en 2013

Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis

scientific article published on 01 August 2004

Role of hippocalcin in mediating Aβ toxicity

artículo científico publicado en 2012

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

artículo científico publicado en 2012

Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.

artículo científico publicado en 2006

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

artículo científico publicado en 2011

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

artículo científico publicado en 2012

Statin Therapy and the Development of Cerebral Amyloid Angiopathy--A Rodent in Vivo Approach

artículo científico publicado en 2016

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

artículo científico publicado en 2005

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.

artículo científico publicado en 2011

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

artículo científico publicado en 2005

Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage

artículo científico publicado en 2014

Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy

artículo científico publicado en 2002

Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

artículo científico publicado en 2013

Transmission and spreading of tauopathy in transgenic mouse brain

artículo científico publicado en 2009

Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice

artículo científico publicado en 2009

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

artículo científico publicado en 2008

Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage

artículo científico publicado en 2006

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

artículo científico publicado en 2010

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda