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Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer

artículo científico publicado en 2016

FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.

artículo científico publicado en 2016

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

artículo científico publicado en 2012

Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures

article

Hypoxia-inducible factors and sphingosine 1-phosphate signaling.

artículo científico publicado en 2011

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

artículo científico publicado en 2014

Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes

scientific article published on 02 December 2020

Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells

artículo científico publicado en 2019

Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer

artículo científico publicado en 2015

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.

artículo científico publicado en 2014

Preclinical evidence that SSR128129E--a novel small-molecule multi-fibroblast growth factor receptor blocker--radiosensitises human glioblastoma.

artículo científico publicado en 2014

Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands.

artículo científico publicado en 2014

The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues

artículo científico publicado en 2020

The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.

artículo científico publicado en 2010

Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

artículo científico publicado en 2019

When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.

artículo científico publicado en 2009