Lista de obras -

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

artículo científico publicado en 2015

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

artículo científico publicado en 2018

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

artículo científico publicado en 2013

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

artículo científico publicado el 15 de junio de 2012

CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

scientific article published on 08 January 2019

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

scientific article published on 24 April 2019

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism ⬇️

artículo científico publicado el 1 de septiembre de 2010

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

artículo científico publicado en 2021

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

artículo científico publicado en 2017

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

artículo científico publicado en 2018

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

artículo científico publicado el 6 de enero de 2011

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

artículo científico publicado en 2017

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

artículo científico publicado en 2015

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

artículo científico publicado en 2014

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

artículo científico publicado en 2013

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

artículo científico publicado en 2017

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

artículo científico publicado en 2017

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

artículo científico publicado en 2016

Multiple amoebic liver abscesses ⬇️

artículo científico publicado el 12 de mayo de 2011

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

artículo científico publicado en 2018

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

artículo científico publicado en 2017

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

artículo científico publicado en 2014

Oxidative stress responses and NRF2 in human leukaemia

artículo científico publicado en 2015

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

artículo científico publicado en 2018

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

artículo científico publicado en 2017

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

artículo científico publicado el 1 de septiembre de 2011

Pulling the plug - halting cancer's theft of mitochondria.

artículo científico publicado en 2017

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

scientific article published on 14 November 2019

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

artículo científico publicado en 2011

TNF mediates the sustained activation of Nrf2 in human monocytes

artículo científico publicado en 2011

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

artículo científico publicado en 2015

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

artículo científico publicado en 2016

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

artículo científico publicado en 2018

Targeting the oncogenic role of miRNA in human cancer using naturally occurring compounds ⬇️

artículo científico publicado el 1 de enero de 2011

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

artículo científico publicado en 2017

The bone marrow microenvironment - Home of the leukemic blasts

artículo científico publicado en 2017

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

artículo científico publicado en 2012

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

artículo científico publicado en 2011

Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei

artículo científico publicado en 2016

Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms

artículo científico publicado en 2019

Understanding life and death decisions in human leukaemias.

artículo científico publicado en 2014

Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013

Understanding the role of miRNA in regulating NF-κB in blood cancer ⬇️

artículo científico publicado el 21 de noviembre de 2011

p16INK4A dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

artículo científico publicado en 2022

Lista de obras de

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism ⬇️

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

Multiple amoebic liver abscesses ⬇️

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

Oxidative stress responses and NRF2 in human leukaemia

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

Pulling the plug - halting cancer's theft of mitochondria.

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

TNF mediates the sustained activation of Nrf2 in human monocytes

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

Targeting the oncogenic role of miRNA in human cancer using naturally occurring compounds ⬇️

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

The bone marrow microenvironment - Home of the leukemic blasts

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei

Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms

Understanding life and death decisions in human leukaemias.

Understanding the role of NRF2-regulated miRNAs in human malignancies.

Understanding the role of miRNA in regulating NF-κB in blood cancer ⬇️

p16INK4A dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors